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Estrone sulfate analogs as estrone sulfatase inhibitors

Steroids, 1995
The high serum concentration of estrone sulfate and the presence of estrone sulfatase in breast tumors constitute an important mechanism of local synthesis of estrogens in the tissue. Thus, inhibitors of estrone sulfatase may be effective in the treatment of estrogen-dependent breast cancer.
P K, Li, R, Pillai, L, Dibbelt
exaly   +3 more sources

Estrone sulfonates as inhibitors of estrone sulfatase

Steroids, 1997
In our continuing quest to design efficient inhibitors of estrone sulfatase activity and to assess the recognition of estrone sulfate surrogates by estrone sulfatase, we synthesized and evaluated several sulfonate derivatives of 5,6,7,8-tetrahydronaphth-2-ol and estrone.
Atul Purohit, Barry V L Potter
exaly   +3 more sources

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