Results 11 to 20 of about 18,229 (121)

The estrobolome: Estrogen‐metabolizing pathways of the gut microbiome and their relation to breast cancer [PDF]

International Journal of Cancer, Volume 157, Issue 4, Page 599-613, 15 August 2025.
Abstract Increasing evidence links the gut microbiome to carcinogenesis. Disruptions in estrogen regulation by the estrobolome—gut microbiota with estrogen‐related functions—may promote breast cancer. However, precise information on estrobolome targets and their underlying mechanisms is limited. This review identifies relevant targets for measuring the
Ashley H. Larnder, Amee R. Manges, Rachel A. Murphy   +2 more
wiley   +2 more sources

Population Variation in Steroid Hormone‐Related Gene Expression and Sexually Dimorphic Communication in the Electric Fish Apteronotus albifrons

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT The development and maintenance of sexually dimorphic behavior often depends on gonadal steroids. Interspecific variation in the magnitude of behavioral sex differences may be mediated by differences in steroid action on neural circuits controlling behavior.
Melissa R. Proffitt, G. Troy Smith
wiley   +1 more source

Mass spectrometry of dendrimers

Mass Spectrometry Reviews, EarlyView.
Abstract Mass spectrometry (MS) has become an essential technique to characterize dendrimers as it proved efficient at tackling analytical challenges raised by their peculiar onion‐like structure. Owing to their chemical diversity, this review covers benefits of MS methods as a function of dendrimer classes, discussing advantages and limitations of ...
McKenna J. Redding, Scott M. Grayson, Laurence Charles   +2 more
wiley   +1 more source

Laryngopharyngeal Reflux: The Impact of Obesity

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT This article provides an overview of gastro‐esophageal (GERD) and laryngopharynegal (LPRD) reflux diseases in the context of obesity as a confounding entity. A detailed review of the clinical presentation, pathogenesis, diagnosis, and treatment of laryngopharyngeal reflux disease may be found elsewhere.
Abdul Latif H. Hamdan, Mary J. Hawkshaw, Robert T. Sataloff   +2 more
wiley   +1 more source

The Role of Vaginal Oestrogen Therapy in Postmenopausal Women With Pelvic Organ Prolapse: Does It Have Any Impact on Perioperative Outcomes? A Systematic Review of Randomised Controlled Trials

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Background Pelvic organ prolapse (POP) affects up to 50% of postmenopausal women, negatively impacting sexual function and quality of life. While surgery remains the primary treatment, increasing attention has been given to perioperative vaginal oestrogen therapy and its potential impact on surgical outcomes.
Gilda Sicilia, Salvatore Giovanni Vitale, Maurizio Nicola D'Alterio, Stefania Saponara, Francesco Scicchitano, Anna Maria Fulghesu, Rossella E. Nappi, Stefano Angioni   +7 more
wiley   +1 more source

Associations of plasma sex‐related hormone and protein levels and alcohol dependence

Addiction, EarlyView.
Abstract Background and Aims Sex‐related hormones and proteins may underlie sex differences in alcohol use disorder characteristics and consequences. Previous reports suggest steroid sex hormones may influence alcohol consumption behaviors while proteins that regulate their circulation levels are rarely investigated.
Ada Man‐Choi Ho, Jennifer R. Geske, Vanessa K. Pazdernik, T. Cameron Waller, Anthony Batzler, Stacey J. Winham, Victor M. Karpyak   +6 more
wiley   +1 more source

No Mate, No Problem: Molecular Mechanisms Involved in Parthenogenesis in the Cosmopolitan Earthworm Aporrectodea trapezoides (Annelida, Clitellata)

Molecular Ecology, EarlyView.
ABSTRACT Approximately, 40% of earthworm species can reproduce by parthenogenesis. This is the case for the cosmopolitan species, Aporrectodea trapezoides, although sexual forms have been described sporadically. We analyse the genotypes and microbiomes of 30 individuals from four localities where both forms appear in order to understand the ...
Irene de Sosa, Marta Turon, Sergi Taboada, José Lorente‐Sorolla, Rosa Fernández, Natasha Tilikj, Alberto Piris, Marta Novo, Patricia Álvarez Campos, Ana Riesgo   +9 more
wiley   +1 more source

Is Adipose Tissue Inflammation the Culprit of Obesity‐Associated Comorbidities?

Obesity Reviews, EarlyView.
ABSTRACT In individuals with obesity, the onset of chronic comorbidities coincides with the excessive accumulation of adipose tissue in various tissue beds. As obesity progresses, adipose tissue becomes increasingly dysfunctional causing chronic low‐grade inflammation.
Laurent Turner, Anjalee I. Wanasinghe, Pamela Brunori, Sylvia Santosa   +3 more
wiley   +1 more source

Vascular health and exercise in females throughout the lifespan: Exploring puberty, pregnancy and menopause

Experimental Physiology, EarlyView.
Abstract This narrative review highlights the impact of exercise on vascular health in females over the lifespan with an emphasis on puberty, pregnancy and menopause. These events encompass substantial changes in sex hormone levels, particularly oestrogens and progesterone.
Kathleen B. Miller, M. Erin Moir, Brandon G. Fico   +2 more
wiley   +1 more source

In Vitro and Clinical Evaluations of UGT1A1‐, P‐gp‐, OATP1B1‐, and BCRP‐Mediated Drug–Drug Interactions of Belumosudil, a Potent ROCK2 Inhibitor

The Journal of Clinical Pharmacology, Volume 65, Issue 8, Page 1026-1038, August 2025.
Abstract Belumosudil is an oral selective rho‐associated coiled‐coil containing protein kinase 2 inhibitor, approved as a treatment for chronic graft‐versus‐host disease. Prior clinical studies demonstrated that coadministration with strong CYP3A4 inducers or proton pump inhibitors requires dose modification of belumosudil.
Olivier Schueller, Lauren Lohmer, Felix Beck, Jeegar Patel, Jasminder Sahi   +4 more
wiley   +1 more source