Our study demonstrated the downregulation of GPD1L and its mediated glycerophospholipid metabolism dysfunction in patients with diminished ovarian reserve. Moreover, we verified that GPD1L knockdown leads to increased cell apoptosis and mitochondrial dysfunction of KGN cells, as well as impaired oocyte quality.
Jiaqi Wu+8 more
wiley +1 more source
Secretary IgA concentrations and plasma cell count changes associated with the estrous cycle in ewes [PDF]
Problems statement: The level of uterine Secretory-IgA (S-IgA) and numbers of plasma cells was measured to observe the differences between two stages of estrous cycle (follicular and luteal phase) in the healthy cycling non pregnant ewes.
Abu Bakar @ Zakaria, Md Zuki+3 more
core +1 more source
Female reproductive function changes during aging with the estrous cycle becoming more irregular during the transition to menopause. We found that intermittent shifts of the light-dark cycle disrupted regularity of estrous cycles in middle-aged female ...
Nana N. Takasu+5 more
doaj +1 more source
Fast activity chirp patterns in focal seizures from patients and animal models
Abstract Time–frequency analysis of focal seizure electroencephalographic signals performed with depth electrodes in human temporal lobe structures has revealed the occurrence at onset of oscillations at approximately 30–100 Hz that feature a monotonic rapid decay in frequency content.
Maxime Lévesque+6 more
wiley +1 more source
17β-Estradiol Potentiates the Reinstatement of Cocaine Seeking in Female Rats: Role of the Prelimbic Prefrontal Cortex and Cannabinoid Type-1 Receptors [PDF]
Clinical observations imply that female cocaine addicts experience enhanced relapse vulnerability compared with males, an effect tied to elevated estrogen phases of the ovarian hormone cycle.
Barron, Laura M.+8 more
core +1 more source
Gene Expression and the Physiological Role of Transforming Growth Factor-α in the Mouse Pituitary [PDF]
Transforming growth factor-alpha (TGF-alpha), a member of the epidermal growth factor (EGF) family, is produced within the mouse anterior pituitaries. However, the cell types of TGF-alpha-expressing cells and the physiological roles of TGF-a within mouse
Kakeya, Tomoshi+5 more
core +1 more source
Disruption of Estrous Cycles in Exercise-Trained Rats
The female Sprague-Dawley rat was evaluated as an animal model for the menstrual irregularities that are common in women athletes. Daily vaginal smears revealed that estrous cycles were markedly disrupted in rats during a 10-week exercise training program, while cycles remained normal in sedentary rats.
Karen A. Carlberg, Melvin J. Fregly
openaire +3 more sources
Estrogen synthesized in the central nervous system enhances MC4R expression and reduces food intake
Estrogen is regulated by the rate‐limiting enzyme aromatase. This study examines how neuroestrogens, estrogen produced in the brain, regulate appetite through the hypothalamus. Using ovariectomized, aromatase knockout, and brain‐specific aromatase‐restored mice, the study found that neuroestrogens suppress appetite by influencing genes like Mc4r.
Takanori Hayashi+8 more
wiley +1 more source
The effect of strategic supplementation with trans-10,cis-12 conjugated linoleic acid on the milk production, estrous cycle characteristics, and reproductive performance of lactating dairy cattle [PDF]
Peer-reviewedThis is the author’s version of a work that was accepted for publication in Journal of Dairy Science. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control ...
Butler, Stephen+5 more
core +1 more source
Emerging roles for integrated stress response signaling in homeostasis
Integrated stress response (ISR), an evolutionarily conserved eukaryotic stress‐adaptive program in eukaryotes, has also been implicated in homeostatic functions. This review covers a broad body of literature and presents several homeostatic functions of ISR in the absence of stress: (a) developmental processes (morphogenesis, differentiation, aging), (
Shyama Nandakumar+2 more
wiley +1 more source