Results 121 to 130 of about 28,938 (241)

Maternal and Early Developmental Effects of Perinatal Exposure to Therapeutically Relevant Doses of Common Nonsteroidal Anti‐Inflammatory Drugs in Rats

open access: yesBirth Defects Research, Volume 118, Issue 8, August 2026.
ABSTRACT Background Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used during pregnancy, yet information on their developmental safety during sensitive perinatal windows remains limited. This study evaluated the maternal and early developmental effects of paracetamol/acetaminophen, aspirin, and nimesulide administered at therapeutically ...
Sara Tawany Caetano dos Santos   +10 more
wiley   +1 more source

High incidence of estrous cycle irregularities in heterogeneous stock (HS) rats is associated with footshock-resistant cocaine intake. [PDF]

open access: yesPsychopharmacology (Berl)
Sneddon EA   +15 more
europepmc   +1 more source

Combined Vitamin D and Resveratrol Treatment Attenuates Motor Deficits and Neurodegeneration in a 6‐OHDA Mouse Model of Parkinson's Disease in Male Mice: A Focus on Sirt1 and Lingo‐1 Pathways in the Ventral Tegmental Area

open access: yesBrain and Behavior, Volume 16, Issue 8, August 2026.
Combined treatment with VitD3 and resveratrol mitigates motor deficits and neurodegeneration in 6‐OHDA‐lesioned mice which was associated with activation of Sirt1 and suppression of Lingo‐1. ABSTRACT Background Parkinson's disease (PD) is characterized by progressive dopaminergic neurodegeneration, leading to severe motor impairments.
Monavareh Soti   +5 more
wiley   +1 more source

Estrogen Receptor Beta Activation Coordinates Liver Lipid Remodeling and Metabolic Fluxes, Preventing Lipotoxicity

open access: yesComprehensive Physiology, Volume 16, Issue 4, August 2026.
ERβ activation restores glucose and lipid homeostasis by remodeling the hepatic lipidome. Mechanistically, it promotes complete fatty acid oxidation and decreases Acetyl‐CoA levels, leading to reduced ketogenesis and lipotoxicity, as demonstrated through in vivo and in vitro approaches.
Debora Santos Rocha   +9 more
wiley   +1 more source

SARS‐CoV‐2 Spike Peptides Trigger Nociceptive Responses Through Spinal TLR4 Pathways

open access: yesEuropean Journal of Pain, Volume 30, Issue 7, August 2026.
ABSTRACT Background Pain is a common neurological manifestation of COVID‐19, yet the mechanisms by which SARS‐CoV‐2 spike protein fragments contribute to nociceptive processing remain poorly understood. We investigated whether spike‐derived peptides directly activate spinal neuroimmune pathways involved in pain signalling.
Bruno Eduardo Silva   +15 more
wiley   +1 more source

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