Results 121 to 130 of about 30,379 (234)

Ciliary Ift20 and Wwtr1 Coordinate Transforming Growth Factor‐β Receptor II Signaling to Maintain Bone–Fat Balance in Skeletal Homeostasis

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Deletion of Ift20 and Wwtr1 in osteoprecursors promoted adipogenic differentiation while suppressing osteogenesis and bone remodeling through dysregulation of TGF‐β signaling. Mechanistically, Ift20 stabilized TβRII by inhibiting c‐Cbl‐mediated ubiquitination and proteasomal degradation. In parallel, Wwtr1 functioned as a transcriptional regulator that
Yang Li   +5 more
wiley   +1 more source

Maternal High-Fat Diet Induces Sex- and Estrous Cycle-Specific Glial Dysregulation in the Peripheral Offspring Retina. [PDF]

open access: yesInvest Ophthalmol Vis Sci
Urbonaite G   +6 more
europepmc   +1 more source

Estrous Cycle In Domestic Animals And Factor Affecting Estrous Cycle

open access: yes
The estrous cycle is a recurring physiological and hormonal process that prepares female domestic animals for ovulation, fertilization and pregnancy. It consists of four major phases—proestrus, estrus, metestrus and diestrus—with each phase characterised by distinct ovarian, reproductive tract and behavioural changes.
openaire   +1 more source

β‐Caryophyllene Mitigates Thioacetamide‐Induced Liver Fibrosis Through CB2‐Mediated Suppression of Necroptosis: A Therapeutic Investigation

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
β‐Caryophyllene is a multifunctional sesquiterpene with significant therapeutic potential. Our findings demonstrate that β‐caryophyllene exerts broad hepatoprotective effects through the activation of cannabinoid type 2 (CB2) receptors. These effects include suppression of oxidative stress–induced injury, attenuation of inflammatory responses ...
Lujain Bader Eddin   +6 more
wiley   +1 more source

Preclinical and Toxicology Studies of LPM7100328, a Novel Oral GnRH Antagonist

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT LPM7100328 is a novel oral GnRH antagonist being developed for the prevention of premature luteinizing hormone (LH) surges in women undergoing controlled ovarian stimulation. The studies presented herein reported assessment of safety in favor of human clinical trials.
Yao Wang   +9 more
wiley   +1 more source

Restraint stress prolongs Diestrus phase of mouse Estrous cycle. [PDF]

open access: yesOxf Open Neurosci
Urbain GR   +4 more
europepmc   +1 more source

Neuroimmune alterations and nociceptive behavior in oral carcinogenesis in rats

open access: yesEuropean Journal of Oral Sciences, Volume 134, Issue 5, October 2026.
Abstract Oral cancer pain is a frequent and debilitating symptom associated with tumor progression. Although neuronal mechanisms have been extensively studied, the role of immune and glial cells in the trigeminal nociceptive pathway remains poorly understood.
Joana Maria dos Santos Alves   +7 more
wiley   +1 more source

Metabolomic and transcriptomic landscape of the bovine uterine lumen during the second week of the estrous cycle. [PDF]

open access: yesJ Anim Sci Biotechnol
Waheed A   +8 more
europepmc   +1 more source

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