Results 141 to 150 of about 28,938 (241)

Reproductive neuroendocrine pathways as modulators of sleep‐related sex differences in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Maingredy Rodrigues Souza, Tathiana A Alvarenga, Renata Mazaro‐Costa, Sergio Tufik, Monica L Andersen   +4 more
wiley   +1 more source

Inhibiting the Endothelial Mechanosensitive Channel Piezo1 Restores Hippocampal Blood–Brain Barrier Integrity to Improve Anesthesia‐ and Surgery‐Induced Cognitive Decline

MedComm, Volume 7, Issue 8, August 2026.
Approximately 10%–30% of elderly patients develop cognitive decline after surgery. How brain regions coordinate cellular networks to mediate this remains unclear. Anesthesia/surgery induces Piezo1 in hippocampal endothelial cells of aged mice. Endothelial Piezo1 deletion restores BBB integrity and improves cognition.
Yong Qiu, Chunheng Mo, Jinyan Wu, Jiachen Li, Shiyu Xu, Lu Chen, Liyin Zhang, Xingming Huang, Yi Zhang, Meng Sun, Yi Kang, Tao Zhu, Bi‐Sen Ding, Guo Chen   +13 more
wiley   +1 more source

Estrous Cycle Influences Cell-Type-Specific Translatomic Signatures of Repeated Ketamine Exposure in the Rat Nucleus Accumbens. [PDF]

eNeuro
Saland SK, Duclot F, Lobo MK, Kabbaj M.
europepmc   +1 more source

Safety Evaluation of an Aqueous Root and Leaf Extract of Ashwagandha ( Withania somnifera )

Phytotherapy Research, Volume 40, Issue 8, Page 5030-5047, August 2026.
Sensoril, an aqueous root and leaf extract of ashwagandha showed no evidence of mutagenicity in the in vitro Ames assay, was negative in the in vitro micronucleus, in vivo mammalian bone marrow chromosome aberration assays, and was well tolerated in the rat at up to 4000 mg/kg BW/day when administered orally for a period of 90 days. The data from these
Mukesh Summan, Candace L. Doepker, Gregory P. Brorby   +2 more
wiley   +1 more source

Estrous cycle stage gates the effect of stress on reward learning. [PDF]

Neuropsychopharmacology
Johnston MP, Garcia-Castañeda BI, Cedillo LG, Patel SK, Vargas VS, Wanat MJ.   +5 more
europepmc   +1 more source

Mitochondria Dictate Progressive Versus Bimodal Aging of the Mammary Gland

Aging Cell, Volume 25, Issue 8, August 2026.
Breast cancer shows a bimodal age distribution with a peak at 45 and higher peak at 65. Using mice with different mitochondrial genomes, we show progressive and bimodal patterns of aging of the mammary gland with distinct pro‐tumorigenic age windows. This finding may shed light on the bimodal distribution in humans.
Edmund Charles Jenkins, Mrittika Chattopadhyay, Thelma Mashaka, Miguel Torres‐Martin, Daniela Sia, Igor Bado, Doris Germain   +6 more
wiley   +1 more source

Cognitive neurobehavior and synaptic plasticity after vagus nerve stimulation in female rats: Interaction between estrous cycle and neurostimulation. [PDF]

Bioelectron Med
Olsen LK, Jones KA, Sharma B, Ethridge VT, Gargas NM, Cunningham SD, Rohan JG, Hatcher-Solis CN.   +7 more
europepmc   +1 more source

Diltiazem N‐oxide, a novel ischaemia‐activated prodrug, prevents ischaemia‐induced ventricular fibrillation without off‐target adverse effects

British Journal of Pharmacology, Volume 183, Issue 16, Page 4646-4662, August 2026.
Abstract Background and Purpose Ventricular fibrillation (VF) in coronary heart disease accounts for up to 70% of sudden cardiac death. We examined whether diltiazem N‐oxide (DNO) has ischaemia‐selective antiarrhythmic activity. Experimental Approach Randomised and blinded experiments were performed in rat isolated hearts and in anaesthetised rats to ...
Louise M. Hesketh, Gabriel A. Watson, Francesca Mazzacuva, Zoe Hoare, Thomas R. Eykyn, Michael J. Curtis   +5 more
wiley   +1 more source

Contact sensitisers activate keratinocytes and induce cytotoxicity via Transient Receptor Potential Ankyrin 1 in allergic contact dermatitis

British Journal of Pharmacology, Volume 183, Issue 16, Page 4610-4627, August 2026.
Abstract Background and Purpose Allergic contact dermatitis (ACD) is a frequent inflammatory skin disease with limited therapeutic options. While neuronal Transient Receptor Potential Ankyrin 1 (TRPA1) has been implicated in ACD, the role of keratinocyte TRPA1 remains unclear.
Areej Jaber, Szabina Horváth, Balázs Zoltán Zsidó, Viktória Kormos, János Konkoly, Csaba Hetényi, Erika Pintér, Ágnes Kemény, Rolland Gyulai   +8 more
wiley   +1 more source

Effects of the estrous cycle and sex on stress responses in guinea pigs. [PDF]

Sci Rep
Nemeth M, Herrmann SM, Wallner B, Millesi E.   +3 more
europepmc   +1 more source