Results 171 to 180 of about 55,042 (297)

ESG‐1‐60 and ESG‐1‐61: Novel dopamine D3 receptor‐preferring partial agonists/antagonists that inhibit cocaine taking and seeking in rodents

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 13, Page 2997-3016, July 2025.
Abstract Background and Purpose Preclinical studies suggest that highly selective dopamine D3 receptor (D3R) antagonists or partial agonists hold promise for treating substance use disorders. However, their limited effectiveness in reducing cocaine self‐administration is a major drawback.
Omar Soler‐Cedeño   +9 more
wiley   +1 more source

GnRH-agonist implants suppress reproductive function and affects ovarian LHR and FSHR expression in prepubertal female cats [PDF]

open access: yes, 2017
Axner   +34 more
core   +1 more source

Electroacupuncture Attenuates High‐Fat Diet‐Exacerbated Alzheimer's Pathology by Enhancing TFEB/TFE3‐Mediated Autophagic Clearance of Tau and NLRP3 Inflammasome in 3xTg Mice

open access: yesCNS Neuroscience &Therapeutics, Volume 31, Issue 7, July 2025.
Mechanistic model of EA‐ST36‐mediated reversal of HFD‐induced cognitive impairment in 3xTg‐AD mice through TFEB/TFE3 activation. The model illustrates that EA‐ST36 inhibits MTORC1 and activates TFEB/TFE3, enhancing the autophagy‐lysosomal pathway (ALP), which leads to the effective degradation of Tau aggregates and NLRP3 inflammasome components in the ...
Xiaoyan Zheng   +11 more
wiley   +1 more source

Dehydrocostus Lactone Inhibits Microglia‐Mediated Neuroinflammation by Targeting CYP2A6 to Improve Ischemic Brain Injury

open access: yesCNS Neuroscience &Therapeutics, Volume 31, Issue 7, July 2025.
Dehydrocostus lactone (DHC) inhibits microglia‐mediated neuroinflammation by targeting CYP2A6, reducing the release of pro‐inflammatory factors and improving nerve function impairment, thereby alleviating ischemic brain injury. ABSTRACT Background Neuroinflammation is an important factor in ischemic stroke.
Xin Shu   +7 more
wiley   +1 more source

Estrous cycle dependent expression of oxycodone conditioned reward in rats. [PDF]

open access: yesSci Rep, 2023
Babb JA   +3 more
europepmc   +1 more source

Effects of ovariectomy‐induced osteoporosis and two photobiomodulation protocols on the repair of apical periodontitis in Wistar rats: A microCT study

open access: yesInternational Endodontic Journal, Volume 58, Issue 7, Page 1042-1059, July 2025.
Abstract Aim Osteoporosis is a disease that is related to a higher prevalence and greater volumes of apical periodontitis. The purpose of this study was to evaluate the effect of ovariectomy‐induced osteoporosis and high‐ or low‐level laser photobiomodulation (PBM) on the repair of apical periodontitis (AP) in adult female Wistar rats.
Carolina Horn Troian‐Michel   +12 more
wiley   +1 more source

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