Results 181 to 190 of about 61,834 (330)

Nociceptive Nerve‐Derived CGRP Exacerbates Uterine Fibrogenesis in Adenomyosis by Promoting CD140b+ CD146+ Fibroblast Differentiation

open access: yesAdvanced Science, Volume 12, Issue 45, December 4, 2025.
This study investigates adenomyosis fibrosis in relation to nociceptive nerves. Nociceptive nerve‐secreted CGRP promotes RAMP1hi CD140b+ CD146+ fibroblast differentiation into myofibroblasts through ERK activation, causing severe fibrosis. Rimegepant‐induced CGRP/RAMP1 signaling blockade alleviates fibrosis and restores fertility in a mouse model. This
Zi Ye   +11 more
wiley   +1 more source

Toward a Genetic Signature of Resistance to Activity‐Based Anorexia in Striatal Projecting Cortical Neurons

open access: yesInternational Journal of Eating Disorders, Volume 58, Issue 12, Page 2292-2305, December 2025.
ABSTRACT Objective Converging evidence from neuroimaging studies and genome‐wide association study (GWAS) suggests the involvement of prefrontal cortex (PFC) and striatum dysfunction in the pathophysiology of anorexia nervosa (AN). However, identifying the causal role of circuit‐specific genes in the development of the AN‐like phenotype remains ...
K. Huang   +7 more
wiley   +1 more source

Forest Guardians: The Role of Dense Forests and Water Networks in Supporting Lowland Tapir (Tapirus terrestris) Populations in the Orinoquia Region of Colombia

open access: yesEcology and Evolution, Volume 15, Issue 12, December 2025.
Our study reveals that lowland tapir (Tapirus terrestris ) occupancy in Colombia's Orinoquia region is strongly influenced by dense forests and proximity to water bodies, while anthropogenic factors such as pastures and road networks negatively impact their presence.
Ángela Alviz   +3 more
wiley   +1 more source

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