Results 121 to 130 of about 56,473 (275)

Surgical impact of laparoscopic and laparotomic elective ovariectomy on inflammatory and oxidative stress biomarkers in anestrus dogs

Veterinary Surgery, EarlyView.
Abstract Objective To compare the systemic inflammatory and oxidative stress responses after elective ovariectomy via open surgery (OPEN) or laparoscopy (LAP) in anestrus bitches. Study design Prospective, blinded, randomized clinical trial. Animals A total of 26 healthy bitches.
Alfonso Calabria, Chiara Del Prete, Maria Pia Pasolini, Veronica Palumbo, Maria Anna Nappo, Silvia Ammirati, Davide Ciccarelli, Fabiana Micieli, Michal Andrzej Kosior, Carmine Carbone, Natascia Cocchia   +10 more
wiley   +1 more source

Early life stress and disruption of the ageing trajectory in female rats: Insights into the origins and mechanisms underlying the risk of hypertension

Experimental Physiology, EarlyView.
Abstract Menopause increases the risk of hypertension in women, yet the factors contributing to this important change remain unclear. Because early life stress has persistent and sex‐specific consequences on health, we hypothesized that ageing reveals the latent effects of neonatal maternal separation (NMS) on cardiovascular homeostasis in female rats.
Danuzia Ambrozio‐Marques, Loralie Mei Guay, Alicia A. Koogler, Tim D. Ostrowski, Aline M. Arlindo de Souza, Kathryn Sandberg, Richard Kinkead   +6 more
wiley   +1 more source

Inhaled 5‐HT1B/1D Receptor Antagonist Attenuates Sumatriptan‐Induced Sensitization of Capsaicin‐Sensitive Lung Vagal Afferents: Implications for Preventing Sumatriptan‐Associated Adverse Chest Symptoms

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Our previous study suggests that sumatriptan‐induced chest discomfort is associated with hypersensitivity of CSLV afferents via 5‐HT1B/1D receptors on nerve endings. The present study demonstrates that inhaled 5‐HT1B/1D receptor antagonism suppresses this hypersensitivity without compromising antimigraine efficacy, supporting local pulmonary antagonism
Nai‐Ju Chan, Zung Fan Yuan, Chang‐Chih Kuo, Chun‐Chun Hsu   +3 more
wiley   +1 more source

Sex‐specific impact of repeated adolescent vapour exposure to JWH‐018 on dopamine response, behaviour and pharmacokinetics across adolescence and adulthood

British Journal of Pharmacology, Volume 183, Issue 7, Page 1517-1538, April 2026.
Abstract Background and Purpose Alarming trends show that vaping e‐cigarettes containing synthetic cannabinoid receptor agonists, such as JWH‐018, is increasing among youth. However, the effects of these trends are unclear in both sexes. We therefore characterized the neuropharmacological effects of adolescent JWH‐018 inhalation in male and female rats.
Nicholas Pintori, Cristina Manis, Enrica Spano, Nicola Simola, Alessandro Ieraci, Pierluigi Caboni, Gaetano Di Chiara, Maria Antonietta De Luca   +7 more
wiley   +1 more source

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li, Yanjie Guo, Jianlin Li, Yimeng Li, Leqian Lin, Hoi Kit Matthew Leung, Qingqing Zhang, Kai‐Fai Lee, Ka‐Wang Cheung, Ernest H. Y. Ng, William S. B. Yeung, Philip C. N. Chiu, Cheuk‐Lun Lee   +12 more
wiley   +1 more source

SIRT5–RAC2 Axis Drives Monocyte‐to‐Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency

Advanced Science, Volume 13, Issue 14, 9 March 2026.
SIRT5 desuccinylates and stabilizes RAC2, activating CSF1R‐dependent signaling to drive monocyte differentiation into M0 macrophages and their polarization toward pro‐inflammatory M1 phenotypes in CTX‐induced premature ovarian insufficiency. Inhibiting the SIRT5‐RAC2 axis attenuates inflammation, reduces granulosa cell apoptosis, and preserves ...
Wenjing TanTai, Yaqi Li, Shengnan Liu, Minjuan Wu, Zhixiao Liu, Junfeng Jiang, Jingjing Chen, Xiaoding Xu, Li Li, Chaoqun Li, Fang Zhao, Ye Liu, Haitao Ni, Tengfei Zhang, Mingjuan Xu, Chaofeng Han   +15 more
wiley   +1 more source

Microbial Contributions to Primate Reproduction

Evolutionary Anthropology: Issues, News, and Reviews, Volume 35, Issue 1, March 2026.
ABSTRACT Reproduction is a complex process, and microbes play a far greater role than previously imagined. This review explores the ways that microbiomes influence the rich tapestry of reproductive processes and outcomes within the primate lineage, including pre‐copulatory and post‐copulatory mechanisms.
Silvia Carboni, Abigail E. Asangba, Amanda D. Melin   +2 more
wiley   +1 more source

Behaviour features of the Persian leopard (Panthera pardus saxicolor) during different stages of the estrous cycle

Nature Conservation Research: Заповедная наука, 2016
The implementation of the programme for the reintroduction of the Persian leopard in the Caucasus in Russia allowed carrying out a detailed video monitoring of various aspects of this subspecies' life under captive conditions in the «Center of the ...
Makhar M. Ertuev, Umar A. Semenov
doaj  

Cardamonin Commands the Colonic Metabolite Columbianetin Acetate to Compete Against LPS in Binding HMGB1 in the Kidney, Preventing Lipopolysaccharide‐Induced Renal Tubular Pyroptosis

Food Frontiers, Volume 7, Issue 2, March 2026.
Cardamonin upregulate sd the intestinal metabolite columbianetin acetate, which competitively bound HMGB1 to prevent LPS‐induced renal tubular cell pyroptosis (the figure is created with BioRender). ABSTRACT Sepsis‐associated acute kidney injury (SA‐AKI) results in high mortality due to the lack of effective interventions. The current study reports the
Zihui Zhou, Xuechun Sun, Jian Zhou, Huali Meng, Pengfei Fan, Yufeng Chu, Hao Wu   +6 more
wiley   +1 more source

Selenium‐Containing Tea‐Derived Peptides Activate Alcohol Dehydrogenase and Ameliorate Alcohol‐Induced Liver Injury by Modulating Oxidative Stress Homeostasis

Food Frontiers, Volume 7, Issue 2, March 2026.
The graphical abstract summarizes the experimental workflow: (1) Preparation of selenium‐containing tea‐derived peptides (TSE‐PP) guided by ADH activation; (2) Purification and LC‐MS/MS identification of selenium‐modified peptides; (3) Molecular docking to reveal peptide‐ADH interactions; (4) Evaluation of hangover‐alleviating and hepatoprotective ...
Lixia Zan, Wenyi Zhang, Ning Gao, Jing Fu, Wengang Jin, Xiaoning Zhao, Xinsheng Li, Tianli Yue   +7 more
wiley   +1 more source