Results 141 to 150 of about 115,949,529 (167)

Understanding Specificity of the Mycosin Proteases in ESX/Type VII Secretion by Structural and Functional Analysis

Journal of Structural Biology, 2013
Mycobacteria use specialized ESX secretion systems to transport proteins across their cell membranes in order to manipulate their environment. In pathogenic Mycobacterium tuberculosis there are five paralogous ESX secretion systems, named ESX-1 through ...
Haining Zhu, Wilbert Bitter, Jonathan M Wagner   +2 more
exaly   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

A metabolomics investigation of the function of the ESX-1 gene cluster in mycobacteria

Microbial Pathogenesis, 2016
The ESX-1 gene cluster, encoding the Type-VII secretion (T7S) system and its virulence associated proteins, ESAT-6 and CFP-10, is thought to be responsible for the transport of extracellular proteins across the hydrophobic and highly impermeable, cell envelope of Mycobacterium, and is involved in virulence in Mycobacterium tuberculosis, the causative ...
Du Toit Loots, Conrad C. Swanepoel, Mae Newton-Foot, Nicolaas C. Gey van Pittius   +3 more
openaire   +2 more sources

Discovery of the type VII ESX‐1 secretion needle?

Molecular Microbiology, 2016
SummaryMycobacterium tuberculosis, the etiological agent of human tuberculosis, harbours five ESAT‐6/type VII secretion (ESX/T7S) systems. The first esx gene clusters were identified during the genome‐sequencing project of M. tuberculosis H37Rv. Follow‐up studies revealed additional genes playing important roles in ESX/T7S systems.
Louis S, Ates, Roland, Brosch
openaire   +2 more sources

Esx Systems and the Mycobacterial Cell Envelope: What's the Connection?

Journal of Bacteriology, 2017
Mycobacterial 6-kDa early secreted antigenic target (ESAT-6) system (ESX) exporters transport proteins across the cytoplasmic membrane. Many proteins transported by ESX systems are then translocated across the mycobacterial cell envelope and secreted ...
Rachel E Bosserman, Patricia A DiGiuseppe Champion   +1 more
exaly   +2 more sources

Correlation of Phenotypic Profiles Using Targeted Proteomics Identifies Mycobacterial Esx-1 Substrates [PDF]

Journal of Proteome Research, 2014
Abstract The Esx/WXG-100 (ESAT-6/Wss) exporters are multiprotein complexes that promote protein translocation across the cytoplasmic membrane in a diverse range of pathogenic and nonpathogenic bacterial species. The Esx-1 (ESAT-6 System-1) system mediates virulence factor translocation in mycobacterial pathogens, including the human ...
Matthew Champion, Richard S. Pinapati, Patricia A DiGiuseppe Champion   +2 more
exaly   +3 more sources

Targeting ESX-1 Secretion System to Control Mycobacterial Infection

2020
Resistance to anti-tuberculosis (TB) drug is a major public health problem threatening the progress that has been made in TB care and control worldwide. The rise of mycobacterium resistance to traditional antibiotics has motivated recent efforts to discover new drug candidates that target virulence factors. In this work, we have developed a robust high-
Pingping Jia, Yi Zhang, Jian Xu, Xiaoguang Bai, Shize Peng, Jianyuan Zhao, Yongxin Zhang, Jing Wang, Xiaoyu Li, Kaixia Mi, Dan Yan, Yucheng Wang, Liyan Yu, Yu Lu, Han-Ping Shi, Shan Cen   +15 more
openaire   +1 more source

Rv3868 (EccA1), an essential component of the Mycobacterium tuberculosis ESX-1 secretion system, is thermostable

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013
Rv3868 (EccA1) is an essential CbxX/CfqX-family ATPase of the Mycobacterium tuberculosis ESX-1 secretion system. Previously, we demonstrated that Rv3868 is composed of two domains; a regulatory N-terminal domain (NT-Rv3868) and an ATP binding C-terminal domain (CT-Rv3868).
Amit, Luthra, Amit, Gaur, Ravishankar, Ramachandran   +2 more
openaire   +2 more sources

The role of mycobacterial ESX-1 secretion systems in phagosome escape

Biophysical Journal, 2022
Monika Rangole, Christian Nehls, Susanne Homolka, Laura Paulowski, Flor Vasquez, Florian Maurer, Thomas Gutsmann   +6 more
openaire   +1 more source

Dynamic Regulation of ESX-1 Secretion and Virulence in Mycobacterial Pathogens

Pathogenic mycobacteria are a global health burden. Mycobacterium tuberculosis is the causative agent of the disease tuberculosis and the leading cause of death attributed to an infectious disease globally. Furthermore, infections with non-tuberculous mycobacteria are also increasing in incidence. These bacterial pathogens employ a variety of virulence
openaire   +1 more source

Phagosomal escape and sabotage: The role of ESX-1 and PDIMs in Mycobacterium tuberculosis pathogenesis

International Reviews of Immunology
Mycobacterium tuberculosis (M. tb) employs diverse virulence factors to evade immune defenses and persist intracellularly. The ESAT-6 secretion system-1 (ESX-1) type VII secretion system (T7SS) releases EsxA, EspA, and EspB, inducing phagosomal rupture and cytosolic access while triggering host defenses, including galectin recruitment and stress ...
Mohd, Shariq, Farhan, Ahmed, Onaiza, Ansari, Anam, Mursaleen, Javaid Ahmad, Sheikh   +4 more
openaire   +2 more sources