Results 121 to 130 of about 4,746 (159)
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JAMA: The Journal of the American Medical Association, 1970
To the Editor.— In the review article entitled "Acute Renal Failure" by Merrill (211:289, 1970), it is recommended that a test dose of ethacrynic acid as high as 200 mg be given to assist in determining the existence of prerenal failure. I feel that this procedure carries certain definite hazards.
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To the Editor.— In the review article entitled "Acute Renal Failure" by Merrill (211:289, 1970), it is recommended that a test dose of ethacrynic acid as high as 200 mg be given to assist in determining the existence of prerenal failure. I feel that this procedure carries certain definite hazards.
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Furosemide, Bumetanide, and Ethacrynic Acid
Veterinary Clinics of North America: Equine Practice, 1993Furosemide and, less commonly, bumetanide and ethacrynic acid are potent diuretics administered to horses for a variety of reasons, including prophylaxis of exercise-induced pulmonary hemorrhage. These drugs affect urine volume and composition, and furosemide has marked effects on plasma volume and composition and on systemic hemodynamics at rest and ...
Kenneth W. Hinchcliff, Laurie A. Mitten
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Site of Action of Ethacrynic Acid
Archives of Internal Medicine, 1966ETHACRYNIC acid (MK-595), an unsaturated ketone derivative of phenoxyacetic acid, was reported to be an effective diuretic in experimental animals in 1962. 1,2 Subsequent reports 3-6 have confirmed its diuretic activity in man. The drug has attracted the attention of clinicians because of its potent therapeutic effect in edematous states refractory to ...
George L. Ackerman, William J. Flanigan
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Ethacrynic acid hyperglycaemia in mice [PDF]
Experientia, 1967 L'administration de grandes doses de l'acide Ethacrynic par injection i.p. aux souris produit l'hyperglycemie. Les investigations preliminaires indiquent un role important pour la medulle surrenale dans la production de la reponse hyperglycemique.
J. M. Foy, B. L. Furman
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JAMA: The Journal of the American Medical Association, 1968
To the Editor:— It now appears that we have a series of articles showing a suggested dose response related to the elevation of blood sugar in diabetic patients after being treated with ethacrynic acid. My colleague and I have shown that 100 mg of ethacrynic acid daily does not influence the carbohydrate metabolism of nondiabetic or diabetic ...
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To the Editor:— It now appears that we have a series of articles showing a suggested dose response related to the elevation of blood sugar in diabetic patients after being treated with ethacrynic acid. My colleague and I have shown that 100 mg of ethacrynic acid daily does not influence the carbohydrate metabolism of nondiabetic or diabetic ...
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Cyclic Analog of Ethacrynic Acid
Journal of Pharmaceutical Sciences, 1970The α,β-unsaturated ketone (4,4-dimethyl-2-ethyl-1[4H]-naphthalenon-6-yl)oxyacetic acid (III), a cyclic analog of ethacrynic acid, has been prepared, and its diuretic activity on oral administration to rats and dogs has been evaluated. No significant activity was observed.
George R. Allen, M. Brawner Floyd
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The Pleiotropic Effects of Ethacrynic Acid
American Journal of Therapeutics, 2009Ethacrynic acid (EC), an effective loop diuretic especially in patients allergic to sulfa-containing drugs, possesses a number of potentially useful actions in addition to the inhibition of the Na⁺-K⁺-2Cl⁻ kidney symport. Inhibition of the enzyme glutathione S-transferase plays an important role in reducing chemotherapy drug resistance.
Janos Molnar, John C. Somberg
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Vestibulotoxicity of Ethacrynic Acid
The Laryngoscope, 1977Temporary or permanent vestibulo‐auditory disability may develop after the administration of the diuretic, ethacrynic acid. A transient loss of hearIng is well documented in the literature; yet, it is suspected that permanent deafness requires the interaction of aminoglycoside agents, other ototoxic drugs, or at least renal failure. A review of earlier
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Polarographic Determination of Ethacrynic Acid
Journal of Pharmaceutical Sciences, 1971Polarography was applied to the analysis of ethacrynic acid in the presence of its principal degradation product, a dimer. The application of the polarographic assay to dosage forms is discussed, and some stability data are given.
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Archives of Otolaryngology - Head and Neck Surgery, 1973
Reply We are very grateful to Dr. Cohn for his comments on our article. According to Cohn et al ( Science 171: 910, 1971) and Brusilow ( Fed Proc 31: 298, 1972) low doses (1 to 5 mg/kg) of ethacrynic acid produce an increase of Na+ concentration and a drop of K+ concentration inside the cochlear duct in dogs; however, Silverstein and Yules ...
William G. Thomas, Jiri Prazma
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Reply We are very grateful to Dr. Cohn for his comments on our article. According to Cohn et al ( Science 171: 910, 1971) and Brusilow ( Fed Proc 31: 298, 1972) low doses (1 to 5 mg/kg) of ethacrynic acid produce an increase of Na+ concentration and a drop of K+ concentration inside the cochlear duct in dogs; however, Silverstein and Yules ...
William G. Thomas, Jiri Prazma
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