Results 151 to 160 of about 2,686,486 (201)
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JAMA: The Journal of the American Medical Association, 1966
Ethacrynic acid (Edecrin - MSD), like chlorothiazide, is the product of an intensive search for substances with affinity for sulphydryl groups - a property shown in vitro that is closely linked with clinical diuretic potency. It is an aromatic oxyacetic acid which dissolves poorly in water, well in lipids and is acidic; these properties suggest that it
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Ethacrynic acid (Edecrin - MSD), like chlorothiazide, is the product of an intensive search for substances with affinity for sulphydryl groups - a property shown in vitro that is closely linked with clinical diuretic potency. It is an aromatic oxyacetic acid which dissolves poorly in water, well in lipids and is acidic; these properties suggest that it
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Ototoxicity of the Ethacrynic Acid
Archives of Otolaryngology - Head and Neck Surgery, 1972Ototoxicity of ethacrynic acid in concentrations of 10, 30, and 50 mg/kg was investigated by measuring the endocochlear potentials (EP), cochlear microphonics (CM), whole nerve action potentials (AP), and summation potentials (SP). Results indicated an ototoxic effect of ethacrynic acid in concentrations of 30 and 50 mg/kg, and in concentrations of 10 ...
J, Prazma +3 more
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JAMA: The Journal of the American Medical Association, 1970
To the Editor.— In the review article entitled "Acute Renal Failure" by Merrill (211:289, 1970), it is recommended that a test dose of ethacrynic acid as high as 200 mg be given to assist in determining the existence of prerenal failure. I feel that this procedure carries certain definite hazards.
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To the Editor.— In the review article entitled "Acute Renal Failure" by Merrill (211:289, 1970), it is recommended that a test dose of ethacrynic acid as high as 200 mg be given to assist in determining the existence of prerenal failure. I feel that this procedure carries certain definite hazards.
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JAMA: The Journal of the American Medical Association, 1968
To the Editor:— It now appears that we have a series of articles showing a suggested dose response related to the elevation of blood sugar in diabetic patients after being treated with ethacrynic acid. My colleague and I have shown that 100 mg of ethacrynic acid daily does not influence the carbohydrate metabolism of nondiabetic or diabetic ...
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To the Editor:— It now appears that we have a series of articles showing a suggested dose response related to the elevation of blood sugar in diabetic patients after being treated with ethacrynic acid. My colleague and I have shown that 100 mg of ethacrynic acid daily does not influence the carbohydrate metabolism of nondiabetic or diabetic ...
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Vestibulotoxicity of Ethacrynic Acid
The Laryngoscope, 1977Temporary or permanent vestibulo‐auditory disability may develop after the administration of the diuretic, ethacrynic acid. A transient loss of hearIng is well documented in the literature; yet, it is suspected that permanent deafness requires the interaction of aminoglycoside agents, other ototoxic drugs, or at least renal failure. A review of earlier
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2000
Abstract Ethacrynic acid is a potent, short-acting, renal-loop diuretic; it is now infrequently used, since other loop diuretics, such as furosemide, have a less precipitous dose-response curve. Loop diuretics inhibit electrolyte reabsorption in the thick ascending limb of the loop of Henle; they act at the luminal face of the ...
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Abstract Ethacrynic acid is a potent, short-acting, renal-loop diuretic; it is now infrequently used, since other loop diuretics, such as furosemide, have a less precipitous dose-response curve. Loop diuretics inhibit electrolyte reabsorption in the thick ascending limb of the loop of Henle; they act at the luminal face of the ...
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Furosemide, Bumetanide, and Ethacrynic Acid
Veterinary Clinics of North America: Equine Practice, 1993Furosemide and, less commonly, bumetanide and ethacrynic acid are potent diuretics administered to horses for a variety of reasons, including prophylaxis of exercise-induced pulmonary hemorrhage. These drugs affect urine volume and composition, and furosemide has marked effects on plasma volume and composition and on systemic hemodynamics at rest and ...
K W, Hinchcliff, L A, Mitten
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Cyclic Analog of Ethacrynic Acid
Journal of Pharmaceutical Sciences, 1970The α,β-unsaturated ketone (4,4-dimethyl-2-ethyl-1[4H]-naphthalenon-6-yl)oxyacetic acid (III), a cyclic analog of ethacrynic acid, has been prepared, and its diuretic activity on oral administration to rats and dogs has been evaluated. No significant activity was observed.
M B, Floyd, G R, Allen
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The Pleiotropic Effects of Ethacrynic Acid
American Journal of Therapeutics, 2009Ethacrynic acid (EC), an effective loop diuretic especially in patients allergic to sulfa-containing drugs, possesses a number of potentially useful actions in addition to the inhibition of the Na⁺-K⁺-2Cl⁻ kidney symport. Inhibition of the enzyme glutathione S-transferase plays an important role in reducing chemotherapy drug resistance.
John C, Somberg, Janos, Molnar
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The Clinical Pharmacology of Ethacrynic Acid
American Journal of Therapeutics, 2009Ethacrynic acid (Edecrin) is a loop diuretic that produces a prompt and profound diuresis. The primary action of ethacrynic acid is the inhibition of the activity of the Na⁺-K⁺-2Cl⁻ symporter in the thick ascending limb of the loop of Henle. The onset of action is usually within 30 minutes after an oral dose and within 5 minutes after an intravenous ...
Janos, Molnar, John C, Somberg
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