Results 151 to 160 of about 5,945,207 (220)
Bis-conjugation of Bioactive Molecules to Cisplatin-like Complexes through (2,2'-Bipyridine)-4,4'-Dicarboxylic Acid with Optimal Cytotoxicity Profile Provided by the Combination Ethacrynic Acid/Flurbiprofen. [PDF]
Chemistry, 2020 A facile route to PtII complexes doubly functionalized with bioactive molecules through a bipyridine-type ligand is described. Initially, ligands LEE (containing two ethacrynic acid units), LEF (ethacrynic acid+flurbiprofen) and LEB (ethacrynic acid ...
L. Biancalana +8 more
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Molecular Biology Reports, 2022 Yenigul, Munevver/0000-0003-0468-721X; Gencer Akcok, E. Basak/0000-0002-6559-9144; Akcok, Ismail/0000-0002-5444-3929Background Despite the recent advances in chemotherapy, the outcomes and the success of these treatments still remain insufficient.
Münevver Yenigül +2 more
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The Pleiotropic Effects of Ethacrynic Acid
American Journal of Therapeutics, 2009Ethacrynic acid (EC), an effective loop diuretic especially in patients allergic to sulfa-containing drugs, possesses a number of potentially useful actions in addition to the inhibition of the Na⁺-K⁺-2Cl⁻ kidney symport. Inhibition of the enzyme glutathione S-transferase plays an important role in reducing chemotherapy drug resistance.
John C, Somberg, Janos, Molnar
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The Clinical Pharmacology of Ethacrynic Acid
American Journal of Therapeutics, 2009Ethacrynic acid (Edecrin) is a loop diuretic that produces a prompt and profound diuresis. The primary action of ethacrynic acid is the inhibition of the activity of the Na⁺-K⁺-2Cl⁻ symporter in the thick ascending limb of the loop of Henle. The onset of action is usually within 30 minutes after an oral dose and within 5 minutes after an intravenous ...
Janos, Molnar, John C, Somberg
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Polarographic Determination of Ethacrynic Acid
Journal of Pharmaceutical Sciences, 1971Polarography was applied to the analysis of ethacrynic acid in the presence of its principal degradation product, a dimer. The application of the polarographic assay to dosage forms is discussed, and some stability data are given.
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Evaluation of Platinum–Ethacrynic Acid Conjugates in the Treatment of Mesothelioma
ChemMedChem, 2011Ilaria Zanellato +2 more
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GSTP1-1 stereospecifically catalyzes glutathione conjugation of ethacrynic acid
FEBS Letters, 1998 Using 1H NMR two diastereoisomers of the ethacrynic acid glutathione conjugate (EASG) as well as ethacrynic acid (EA) could be distinguished and quantified individually. Chemically prepared EASG consists of equal amounts of both diastereoisomers. GSTP1-1
Ivonne M C M Rietjens +2 more
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FEBS Letters, 1997 The diuretic drug ethacrynic acid, an inhibitor of pi class glutathione S-transferase, has been tested in clinical trials as an adjuvant in chemotherapy.
Aaron J Oakley +2 more
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Nanoscale, 2015 International audienceThe well-known reactive diuretic ethacrynic acid (EA, Edecrin), with low antiproliferative activities, was chemically modified and grafted onto phosphorus dendrimers and the corresponding simple branched phosphorus dendron-like ...
Nabil El Brahmi +7 more
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