Results 161 to 170 of about 5,945,207 (220)
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Angewandte Chemie, 2020
Despite being a clinically approved intervention for cancer, photodynamic therapy (PDT) still suffers from limitations. Prime among these is a therapeutic response that is mostly oxygen dependent. This limits the utility of PDT in treating hypoxic tumors
Miae Won +6 more
semanticscholar +1 more source
Despite being a clinically approved intervention for cancer, photodynamic therapy (PDT) still suffers from limitations. Prime among these is a therapeutic response that is mostly oxygen dependent. This limits the utility of PDT in treating hypoxic tumors
Miae Won +6 more
semanticscholar +1 more source
Biochemical Pharmacology, 2020
To identify signal transducer and activator of transcription factor 3 (STAT3) inhibitors, we generated STAT3-dependent gene expression signature by analyzing gene expression profiles of DU145 cancer cells treated with STAT3 inhibitor, piperlongumine and ...
Yu-Jin Lee +6 more
semanticscholar +1 more source
To identify signal transducer and activator of transcription factor 3 (STAT3) inhibitors, we generated STAT3-dependent gene expression signature by analyzing gene expression profiles of DU145 cancer cells treated with STAT3 inhibitor, piperlongumine and ...
Yu-Jin Lee +6 more
semanticscholar +1 more source
Ethacrynic acid as a lead structure for the development of potent urease inhibitors
Comptes Rendus Chimie, 2013Ingo Janser +4 more
exaly +2 more sources
Ototoxicity of the Ethacrynic Acid
Archives of Otolaryngology - Head and Neck Surgery, 1972Ototoxicity of ethacrynic acid in concentrations of 10, 30, and 50 mg/kg was investigated by measuring the endocochlear potentials (EP), cochlear microphonics (CM), whole nerve action potentials (AP), and summation potentials (SP). Results indicated an ototoxic effect of ethacrynic acid in concentrations of 30 and 50 mg/kg, and in concentrations of 10 ...
J, Prazma +3 more
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Drug and therapeutics bulletin, 1966
Ethacrynic acid (Edecrin - MSD), like chlorothiazide, is the product of an intensive search for substances with affinity for sulphydryl groups - a property shown in vitro that is closely linked with clinical diuretic potency. It is an aromatic oxyacetic acid which dissolves poorly in water, well in lipids and is acidic; these properties suggest that it
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Ethacrynic acid (Edecrin - MSD), like chlorothiazide, is the product of an intensive search for substances with affinity for sulphydryl groups - a property shown in vitro that is closely linked with clinical diuretic potency. It is an aromatic oxyacetic acid which dissolves poorly in water, well in lipids and is acidic; these properties suggest that it
+9 more sources
JAMA: The Journal of the American Medical Association, 1970
To the Editor.— In the review article entitled "Acute Renal Failure" by Merrill (211:289, 1970), it is recommended that a test dose of ethacrynic acid as high as 200 mg be given to assist in determining the existence of prerenal failure. I feel that this procedure carries certain definite hazards.
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To the Editor.— In the review article entitled "Acute Renal Failure" by Merrill (211:289, 1970), it is recommended that a test dose of ethacrynic acid as high as 200 mg be given to assist in determining the existence of prerenal failure. I feel that this procedure carries certain definite hazards.
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JAMA: The Journal of the American Medical Association, 1968
To the Editor:— It now appears that we have a series of articles showing a suggested dose response related to the elevation of blood sugar in diabetic patients after being treated with ethacrynic acid. My colleague and I have shown that 100 mg of ethacrynic acid daily does not influence the carbohydrate metabolism of nondiabetic or diabetic ...
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To the Editor:— It now appears that we have a series of articles showing a suggested dose response related to the elevation of blood sugar in diabetic patients after being treated with ethacrynic acid. My colleague and I have shown that 100 mg of ethacrynic acid daily does not influence the carbohydrate metabolism of nondiabetic or diabetic ...
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Vestibulotoxicity of Ethacrynic Acid
The Laryngoscope, 1977Temporary or permanent vestibulo‐auditory disability may develop after the administration of the diuretic, ethacrynic acid. A transient loss of hearIng is well documented in the literature; yet, it is suspected that permanent deafness requires the interaction of aminoglycoside agents, other ototoxic drugs, or at least renal failure. A review of earlier
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Cyclic Analog of Ethacrynic Acid
Journal of Pharmaceutical Sciences, 1970The α,β-unsaturated ketone (4,4-dimethyl-2-ethyl-1[4H]-naphthalenon-6-yl)oxyacetic acid (III), a cyclic analog of ethacrynic acid, has been prepared, and its diuretic activity on oral administration to rats and dogs has been evaluated. No significant activity was observed.
M B, Floyd, G R, Allen
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Furosemide, Bumetanide, and Ethacrynic Acid
Veterinary Clinics of North America: Equine Practice, 1993Furosemide and, less commonly, bumetanide and ethacrynic acid are potent diuretics administered to horses for a variety of reasons, including prophylaxis of exercise-induced pulmonary hemorrhage. These drugs affect urine volume and composition, and furosemide has marked effects on plasma volume and composition and on systemic hemodynamics at rest and ...
K W, Hinchcliff, L A, Mitten
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