Results 131 to 140 of about 4,746 (159)
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The Clinical Pharmacology of Ethacrynic Acid
American Journal of Therapeutics, 2009Ethacrynic acid (Edecrin) is a loop diuretic that produces a prompt and profound diuresis. The primary action of ethacrynic acid is the inhibition of the activity of the Na⁺-K⁺-2Cl⁻ symporter in the thick ascending limb of the loop of Henle. The onset of action is usually within 30 minutes after an oral dose and within 5 minutes after an intravenous ...
John C. Somberg, Janos Molnar
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Cardiorenal hemodynamic effects of ethacrynic acid
American Heart Journal, 1966Abstract Ethacrynic acid, studied in normal subjects as well as in patients with hypertension or edema, reduces glomerular filtration rate slightly and has little or no effect on estimated renal plasma flow while decreasing filtration fraction. It causes a prompt increase in the volume of urine, with the excretion of 8 to 19 per cent of sodium ...
Howard L. Nash +4 more
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Ethacrynic acid accumulation by renal tissue
Biochemical Pharmacology, 1972Abstract During incubation in isotonic glucose-salt medium, thin slices of rabbit kidney tissue accumulate [2- 14 C]ethacrynic acid against a concentration gradient. Saturation does not occur in 60 min of incubation, by which time the accumulation is about 10-fold when expressed as a slice : medium ratio.
A.F. Almeida, J.S. Charnock
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Diuretic activity of Mannich base derivatives of ethacrynic acid and certain ethacrynic acid analogs
Journal of Medicinal Chemistry, 1978Various Mannich base derivatives of selected phenoxyacetic acid type diuretics were synthesized and their diuretic potency was evaluated in dogs. It is concluded that the Mannich bases possess little, if any, diuretic activity of their own. Those Mannich bases that do possess diuretic activity undoubtedly do so as a consequence of an elimination ...
Gary O. Rankin, Daniel A. Koechel
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Ethacrynic Acid: A Non-Diabetogenic Diuretic
Diseases of the Chest, 1967A new and potent diuretic agent, ethacrynic acid, has been investigated in a preliminary study, to determine the effect on glucose tolerance in non-diabetics, mild diabetics and severe diabetics. The study indicates that ethacrynic acid has no significant diabetogenic effect. Side effects attributable to ethacrynic acid occurred in five patients.
Seymour Diamond, Edwin Feldman
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Ethacrynic Acid in Acute Pulmonary Edema
New England Journal of Medicine, 1965DIURETICS are frequently used as part of the therapeutic regimen in the management of patients in acute pulmonary edema. The decreased cardiac output and reduced glomerular filtration rate of patients in acute pulmonary edema often result in a disappointing diuretic response, even with the most potent diuretics currently available. The delay of four to
Robert I. Levy, Stuart L. Fine
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Electrophysiologic Properties of Ethacrynic Acid in Man
Angiology, 1983Ethacrynic acid is a potent oral diuretic and saluretic agent. It has been used extensively in the treatment of heart failure and its effects on cardiovascular dynamics are well established. The clinical relief of the symptoms of pulmonary congestion frequently precedes any demonstrable diuretic effect suggesting that extra renal factors may also be ...
F. Chandy +3 more
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Effect of Ethacrynic Acid on the Stria Vascularis
Archives of Otolaryngology, 1977The stria vascularis of young albino guinea pigs was examined by scanning electron microscopy at intervals of 30, 60, and 240 minutes after the intracardiac administration of ethacrynic acid (70 mg/kg). Results from this study showed that the appearance of large intercellular spaces in the intermediate region of the stria vascularis was due to acute ...
Karl L. Horn +2 more
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Ethacrynic acid and kidney cell metabolism
Biochemical Pharmacology, 1972Abstract Cellular effects of ethacrynic acid were examined in the rabbit and rat kidney. Emphasis was placed on levels of the compound in vitro lower than those employed in earlier studies. In the present study in vitro , ethacrynic acid is without effect on sodium-potassium-dependent adenosine triphosphatase (ATPase) activity.
Erwin J. Landon, David F. Fitzpatrick
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METABOLIC EFFECTS OF ETHACRYNIC ACID IN THE AGED*
Journal of the American Geriatrics Society, 1970AbstractEthacrynic acid was given to 41 aged men and women who had previously been treated with thiazides for congestive heart failure. Twenty‐three of these patients had diabetes. After ten weeks of maintenance therapy with ethacrynic acid, there were no statistically significant changes in the levels of blood urea nitrogen, serum uric acid, chloride,
Gilbert Rosenberg, Joseph Wener
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