Results 41 to 50 of about 1,123,887 (321)

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Water/Ethanol and 13X Zeolite Pairs for Long-Term Thermal Energy Storage at Ambient Pressure

Frontiers in Energy Research, 2019
Thermal energy storage is a key technology to increase the global energy share of renewables—by matching energy availability and demand—and to improve the fuel economy of energy systems—by recovery and reutilization of waste heat.
Matteo Fasano, Luca Bergamasco, Alessio Lombardo, Manuele Zanini, Eliodoro Chiavazzo, Pietro Asinari   +5 more
doaj   +1 more source

Performance characteristics of single-cylinder spark-ignition engine and its pollutant emissions by using methanol and ethanol fuel blended with gasoline [PDF]

International Journal of Biomedicine and Public Health, 2018
Introduction:Increasing air pollution is one of the problems of living in large cities. Motor vehicles are the main source of emissions of these pollutants.
Ramazan Ali Dianati Tilaki, Houssein Chabok, Reza Sadeghnezhad   +2 more
doaj   +1 more source

Molecular Description of the Coil-to-Globule Transition of Poly(N-isopropylacrylamide) in Water/Ethanol Mixture at Low Alcohol Concentration [PDF]

Journal of Molecular Liquids, 2019, 2019
Poly(N-isopropylacrylamide), PNIPAM, is a widely studied polymer, which serves as a key constituent of nanostructured soft materials with responsive properties. Upon increasing temperature the PNIPAM polymer chain undergoes a reversible coil-to-globule transition at ~305K, which is reflected by a volume phase transition in cross-linked architectures ...
arxiv   +1 more source

Multiplex single‐cell profiling of putative cancer stem cell markers ALDH1, SOX9, SOX2, CD44, CD133 and CD15 in endometrial cancer

Molecular Oncology, EarlyView.
Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien, Marta E. Hjelmeland, Hege F. Berg, Rose M. Gold, Kathrine Woie, Lars A. Akslen, Ingfrid S. Haldorsen, Camilla Krakstad   +7 more
wiley   +1 more source

The calcineurin-responsive transcription factor Crz1 regulates the expression of CMK2 via a sole CDRE site in its promoter in budding yeast

Scientific Reports
As a yeast homolog of mammalian calcium/calmodulin-dependent protein kinase II (CaMKII), Cmk2 functions as a negative regulator of calcium signaling in Saccharomyces cerevisiae.
Linghuo Jiang, Yiying Gu, Yongqiang Jiang, Liudan Wei, Lijun Meng, Ni Guan   +5 more
doaj   +1 more source

Nitrogen doped In$_2$O$_3$-ZnO nanocomposite thin film based sensitive and selective ethanol sensor [PDF]

arXiv, 2022
Nanocomposite metal oxide thin films exhibit assuring qualities in the field of gas sensors because of the collective opportunities provided by the heterointerface formation. In this work, we present the synthesis of nitrogen doped mesoporous In$_2$O$_3$-ZnO nano-composite thin films by simple wet chemical method using urea as the nitrogen precursor ...
arxiv  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Efficacy and reliability of various grades of processed honey as a fixative: A comparative study

Indian Journal of Dental Sciences, 2021
Introduction: Ethanol is a traditional cytofixative which is widely used for oral exfoliative cytology. Due to its limitations, a search of better, eco-friendly, and cost-effective fixative was explored.
Kunal Sah, B J Janardhan, Raj Kumar Srivastava, Sanjay Nigam   +3 more
doaj   +1 more source