Results 61 to 70 of about 1,472,047 (314)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

High-Fat Diet Induced Alteration of Mice Microbiota and the Functional Ability to Utilize Fructooligosaccharide for Ethanol Production

Frontiers in Cellular and Infection Microbiology, 2020
High-fat diet (HFD) leads to enhancement in various parameters of mice like weight, fasting glucose levels, adipose tissue, and also the liver weight in male C57 BL/6 J mice.
Rajnish Prakash Singh, Diana Abu Halaka, Zvi Hayouka, Oren Tirosh   +3 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Hyperpolarized para-Ethanol [PDF]

The Journal of Physical Chemistry B, 2015
We show that an imbalance between the populations of singlet (S) and triplet (T) states in pairs of magnetically equivalent spins can be generated by dissolution dynamic nudear polarization: In partly deuterated ethanol ((CD3CH2OD)-C-13), this T/S imbalance can be transferred by cross-relaxation to observable, enhanced signals of protons and coupled C ...
Mammoli, Daniele, Vuichoud, Basile, Bornet, Aurélien, Milani, Jonas, Dumez, Jean-Nicolas, Jannin, Sami, Bodenhausen, Geoffrey   +6 more
openaire   +6 more sources

Aplicação da metodologia de planejamento fatorial e análise de superfícies de resposta para otimização da fermentação alcoólica Application of the factorial design and response surface methodology for optimization of alcoholic fermentation

Química Nova, 2008
In the present work, the influence of the amount of nitrogen and phosphorus and degrees Brix on the yield and productivity of alcoholic fermentation has been evaluated. The methodology used was factorial design and response surface analysis.
José Alexsandro Silva, Bolívar Ponciano Goulart de Lima Damasceno, Flávio Luiz Honorato da Silva, Marta Suely Madruga, Davi Pereira de Santana   +4 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

The U.S. ethanol industry [PDF]

Ethanol is vital to achieving greater American energy independence. It is today's only viable and available fuel that can be substituted for gasoline. Unlike oil, ethanol is renewable-it will never run out.
Mark D. Stowers
core  

Incidence of ICD-Based Diagnoses of Alcohol-Related Disorders and Diseases from Swedish Nationwide Registers and Suggestions for Coding

Clinical Epidemiology, 2020
David Bergman,1 Hannes Hagström,2– 4 Andrea Johansson Capusan,5,6 Karl Mårild,7,8 Fredrik Nyberg,9 Kristina Sundquist,10 Jonas F Ludvigsson1,11– 13 1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet ...
Bergman D, Hagström H, Capusan AJ, Mårild K, Nyberg F, Sundquist K, Ludvigsson JF   +6 more
doaj  

Water/Ethanol and 13X Zeolite Pairs for Long-Term Thermal Energy Storage at Ambient Pressure

Frontiers in Energy Research, 2019
Thermal energy storage is a key technology to increase the global energy share of renewables—by matching energy availability and demand—and to improve the fuel economy of energy systems—by recovery and reutilization of waste heat.
Matteo Fasano, Luca Bergamasco, Alessio Lombardo, Manuele Zanini, Eliodoro Chiavazzo, Pietro Asinari   +5 more
doaj   +1 more source