Results 41 to 50 of about 1,472,047 (314)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The calcineurin-responsive transcription factor Crz1 regulates the expression of CMK2 via a sole CDRE site in its promoter in budding yeast

Scientific Reports
As a yeast homolog of mammalian calcium/calmodulin-dependent protein kinase II (CaMKII), Cmk2 functions as a negative regulator of calcium signaling in Saccharomyces cerevisiae.
Linghuo Jiang, Yiying Gu, Yongqiang Jiang, Liudan Wei, Lijun Meng, Ni Guan   +5 more
doaj   +1 more source

Boron Modified Bifunctional Cu/SiO₂ Catalysts with Enhanced Metal Dispersion and Surface Acid Sites for Selective Hydrogenation of Dimethyl Oxalate to Ethylene Glycol and Ethanol

Nanomaterials, 2021
Boron (B) promoter modified Cu/SiO2 bifunctional catalysts were synthesized by sol-gel method and used to produce ethylene glycol (EG) and ethanol (EtOH) through efficient hydrogenation of dimethyl oxalate (DMO).
Deliang Yang, Runping Ye, Ling Lin, Rong Guo, Peiyu Zhao, Yanchao Yin, Wei Cheng, Wenpeng Yuan, Yuangen Yao   +8 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Allopregnanolone and Pentobarbital Infused Into the Nucleus Accumbens Substitute for the Discriminative Stimulus Effects of Ethanol [PDF]

, 2001
BACKGROUND: The discriminative stimulus effects of ethanol are mediated in part by the gamma-aminobutyric acid type A (GABA(A)) receptor system. We have previously shown that microinjections of the competitive GABA(A) agonist muscimol in the nucleus ...
Nannini, Michelle A., Mehmert, Kirstin K., Olive, M. Foster, Hodge, Clyde W., Kelley, Stephen P.   +4 more
core   +1 more source

Optimization of gallic acid-enriched ultrasonic-assisted extraction from mango peels

Open Chemistry, 2023
Gallic acid is recognized as a notable bioactive compound among secondary polyphenolic metabolites. In the current study, gallic acid-enriched extracts were obtained from mango peels using different solvents (ethanol or water) via ultrasound-assisted ...
Riaz Tuba, Hayat Zafar, Akram Kashif, Saleem Kinza, Rehman Hafeez ur, Azam Muhammad, Tariq Zara, Rehman Shafiq ur, Meraj Asif, Farooq Umar, Shafi Afshan   +10 more
doaj   +1 more source

A Novel Amperometric Biosensor Based on Poly(allylamine hydrochloride) for Determination of Ethanol in Beverages

Sensors, 2021
Herein, we report on a new type of ethanol biosensor based on a screen-printed electrode modified with poly(allylamine hydrochloride). The alcohol dehydrogenase was immobilized on the surface of the sensor using the sol–gel matrix.
Oana Maria Istrate, Lucian Rotariu, Camelia Bala   +2 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Dimers of Ethanol

The Journal of Physical Chemistry A, 2004
The energy difference between the gauche and trans structures of ethanol is determined at the CCSD(T)/aug-cc-pVTZ level. Five classes of dimer structures exist due to the two monomer conformations. In a systematic way 600 structures were generated as initial structures for the dimer geometry optimization.
openaire   +2 more sources