Results 51 to 60 of about 2,330,903 (349)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Moderate (2%, v/v) Ethanol Feeding Alters Hepatic Wound Healing after Acute Carbon Tetrachloride Exposure in Mice

Biomolecules, 2016
Wound healing consists of three overlapping phases: inflammation, proliferation, and matrix synthesis and remodeling. Prolonged alcohol abuse can cause liver fibrosis due to deregulated matrix remodeling.
Krutika T. Deshpande, Shinlan Liu, Jennifer M. McCracken, Lu Jiang, Ta Ehpaw Gaw, Lindsey N. Kaydo, Zachary C. Richard, Maura F. O’Neil, Michele T. Pritchard   +8 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Ethanol Exposure Up-Regulates PD-L1/PD-1 Immune Checkpoint Pathway and Promotes Mammary Tumor Development

Frontiers in Oncology, 2022
Alcohol consumption in women enhances breast cancer incidence and ethanol is the main causal factor. Compromised host immunity through immunosuppression facilitates the development of many types of cancer, including breast cancer.
Wenhua Xu, Wenhua Xu, Linqing Wu, Linqing Wu, Mei Xu, Jia Luo, Gang Chen   +6 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Comparison between ethanol and hexane for oil extraction from Quercus suber L. fruits

Grasas y Aceites, 2003
The aim of this study was to (i) evaluate the feasibility of replacing n-hexane with ethanol for the extraction of oil from Quercus suber fruits and (ii) optimize, at lab scale, sample preparation and extraction time for both solvents used (n-hexane vs ...
Suzana Ferreira-Dias, Dina G. Valente, José M.F. Abreu   +2 more
doaj   +1 more source

A Case Study of the Ethanol CleanCook Stove Intervention and Potential Scale-Up in Ethiopia [PDF]

, 2018
Background Approximately 80% of Ethiopia\u27s energy consumption is dominated by woody biomass fuel use, resulting in 91.2 million tons of firewood and 4.2 million tons of charcoal consumed annually.
Benka-Coker, Megan L., Getaneh, Desalegn, Milano, Alex, Stokes, Harry, Tadele, Wubshet   +4 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The calcineurin-responsive transcription factor Crz1 regulates the expression of CMK2 via a sole CDRE site in its promoter in budding yeast

Scientific Reports
As a yeast homolog of mammalian calcium/calmodulin-dependent protein kinase II (CaMKII), Cmk2 functions as a negative regulator of calcium signaling in Saccharomyces cerevisiae.
Linghuo Jiang, Yiying Gu, Yongqiang Jiang, Liudan Wei, Lijun Meng, Ni Guan   +5 more
doaj   +1 more source

Optimization of Bioethanol In Silico Production Process in a Fed-Batch Bioreactor Using Non-Linear Model Predictive Control and Evolutionary Computation Techniques

Energies, 2017
Due to growing worldwide energy demand, the search for diversification of the energy matrix stands out as an important research topic. Bioethanol represents a notable alternative of renewable and environmental-friendly energy sources extracted from ...
Hanniel Ferreira Sarmento de Freitas, José Eduardo Olivo, Cid Marcos Gonçalves Andrade   +2 more
doaj   +1 more source