Results 71 to 80 of about 4,347 (272)

The Effect of Ligand Reactivity and Carrier Mechanics on Thiol‐Mediated Cellular Uptake for miRNA Nano‐Drugs

Advanced Science, EarlyView.
The effect of ligand reactivity and carrier mechanics on thiol‐mediated uptake was investigated at the single‐molecule/particle level. The interaction kinetics of LA and AspA with membrane thiols were quantified; AspA is more efficient due to the higher binding affinity, greater binding stability, and more double‐disulfide binding, as well as greater ...
Zhuang Zhang, Hui Wang, Hao Zhang, Zhenkuan Cao, Zehui Liu, Siying Li, Hongda Wang, Yuping Shan   +7 more
wiley   +1 more source

Synthetic Chemicals as Potential Tracers of Impacts of Fracturing Fluids on Groundwater

Pollutants
Application of hydraulic fracturing to produce “unconventional” oil and gas from shale formations and other low-permeability geological units has raised concerns about the potential environmental impacts, including potential adverse effects of fracturing
Dale R. Van Stempvoort, Susan Brown, Priyantha Kulasekera, Pamela Collins   +3 more
doaj   +1 more source

Thermodynamic Properties of Binary Mixtures Containing Ionic Liquid 1‑Butyl-3-methylimidazolium Thiocyanate and Ethanolamines at Different Temperatures: Measurement and PC-SAFT Modeling

, 2023
Thermodynamic properties of liquid absorbents are important for industrial applications. Ionic liquids (ILs) are more efficient alternatives to organic solvents that are used for CO2 absorption and storage. The IL, 1-butyl-3-methylimidazolium thiocyanate
Hemayat Shekaari (1671145), Siamak Shahabadi (17304308), Behrang Golmohammadi (10720950), Sanaz Gharehzadeh Shirazi (17304305)   +3 more
core   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

Chromatographic Separation Methods for Fatty Acyls

Frontiers in Physiology, 2016
Recognition of the contributions of lipids to cellular physiology, both as structural components of the membrane and as modulatory ligands for membrane proteins, has increased in recent years with the development of the biophysical and biochemical tools ...
Erin B. Divito, Kristin M. Kroniser, Michael Cascio   +2 more
doaj   +1 more source

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Isotachophoretic determination of ethanolamines

, 2019
V tomto článku je popsáno stanovení ethanolaminů v kosmetických výrobcích kapilární izotachoforézou. Jako vedoucí elektrolyt byl použit 0,01 M octan sodný, jehož pH bylo upraveno kyselinou octovou na hodnotu 4,6, a jako koncový elektrolyt 0,01 M kyselina
Bartoš, Martin, Janečková, Michaela
core   +1 more source

The Effect of Tungstate and Ethanolamines Added in Tap Water on Corrosion Inhibition of Ductile Cast Iron Pipe for Nuclear Power Plants

Metals, 2020
Cast iron is primarily used in buried piping to transport water in the fire protection system of nuclear power plants; ductile cast iron is generally used for domestic nuclear power plants.
Butaek Lim, Kitae Kim, Hyunyoung Chang, Heungbae Park, Youngsik Kim   +4 more
doaj   +1 more source

Dual Compartmentalization of GSTA4 Suppresses Ferroptosis to Drive Antiandrogen Resistance in Prostate Cancer

Advanced Science, EarlyView.
The schematic diagram depicts a compartmentalized anti‐ferroptotic defense mechanism mediated by GSTA4. GSTA4 is upregulated and localizes to the cytoplasm in ENZR cells, where it detoxifies 4‐HNE via a non‐canonical GSH‐dependent pathway. Under oxidative stress, GSTA4 translocates to mitochondria, interacts with PGAM5, and blocks Drp1 Ser637 ...
Yong Luo, Wei Zhuang, Zean Li, Yiming Lai, Yongyi Ou, Dongquan Li, Shanhe Huang, Tianlong Luo, Jintao Hu, Bingliang Chen, Jianhan Fu, Tao Zhuo, Hankun Jiang, Yin Lu, Hai Huang, Kewei Xu, Shengmeng Peng, Qing Yuan   +17 more
wiley   +1 more source