Results 91 to 100 of about 20,859 (265)

Lipidomics Based on HILIC-ESI-HRMS Reveal Subtle Changes in the Mitochondrial Phospholipidome of Mouse Embryonic Fibroblasts Expressing Pathogenic Variants of Human OPA1 Protein

Molecules
Pathogenic variants of the mammalian optic atrophy 1 (OPA1) protein, a key regulator of mitochondrial fusion, may lead to severe mitochondrial dysfunction and morphological alterations, and have also been proposed to be involved in remodeling the ...
Andrea Castellaneta, Ilario Losito, Vito Porcelli, Serena Barile, Alessandra Maresca, Valentina Del Dotto, Penelope Magnoni, Claudia Zanna, Ludovica Sofia Guadalupi, Valeria Cinquepalmi, Cosima Damiana Calvano, David C. Chan, Valerio Carelli, Luigi Palmieri, Tommaso R. I. Cataldi   +14 more
doaj   +1 more source

Effects of tumour necrosis factor α upon the metabolism of the endocannabinoid anandamide in prostate cancer cells.

PLoS ONE, 2017
Tumour necrosis factor α (TNFα) is involved in the pathogenesis of prostate cancer, a disease where disturbances in the endocannabinoid system are seen.
Jessica Karlsson, Sandra Gouveia-Figueira, Mireille Alhouayek, Christopher J Fowler   +3 more
doaj   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Mechanical stability in flexible perovskite solar cells: Interface engineering and device design

FlexMat, EarlyView.
Statistics of the improvement methods for f‐PSCs. Abstract Flexible perovskite solar cells (f‐PSCs) demonstrate significant potential for application in next‐generation wearable electronic devices and photovoltaic building integration due to their high power conversion efficiency and excellent power‐to‐weight ratio. However, the inherent brittleness of
Hong‐Yi Hou, Xin‐Yi Zeng, Jian‐Xin Tang, Yan‐Qing Li   +3 more
wiley   +1 more source

Human gut microbiota and their production of endocannabinoid-like mediators are directly affected by a dietary oil

Gut Microbes
Dietary omega-3 polyunsaturated fatty acids (n-3 PUFAs) and the gut microbiome affect each other. We investigated the impact of supplementation with Buglossoides arvensis oil (BO), rich in stearidonic acid (SDA), on the human gut microbiome.
Charlène Roussel, Mathilde Sola, Jacob Lessard-Lord, Nayudu Nallabelli, Pamela Généreux, Camille Cavestri, Oumaima Azeggouar Wallen, Rosaria Villano, Frédéric Raymond, Nicolas Flamand, Cristoforo Silvestri, Vincenzo Di Marzo   +11 more
doaj   +1 more source

Seed lipid profiles of perennial ryegrass: Global patterns and differentiation of ryegrass cultivars and Epichloë endophytes

Grassland Research, EarlyView.
Seed lipid profiles from three ryegrass cultivars infected with AR501 show distinct changes in the medium‐chain diacylglycerols, triacylglycerols and sphingolipids. The differential peal LN745.5052_5.78 can be identified as PG 16:0_18:2 with the supporting ms2 fragmentation spectrum. Abstract Background Forage perennial ryegrass (Lolium perenne L.) has
Mingshu Cao, Wei Zhang, Wade J. Mace, Christine R. Voisey, David E. Hume, Richard D. Johnson, Sushma Prakash   +6 more
wiley   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

PTQ10‐based organic photodetectors for visible light detection and their tolerance to impurities

Polymer International, EarlyView.
PTQ10‐based organic photodetectors were found to be very sensitive to the presence of Pd(PPh3)4 catalyst traces, impacting the transport properties and light detection capacities. Abstract PTQ10 donor polymer has attracted a lot of interest in organic optoelectronics, particularly in the field of organic photovoltaics, owing to its ease of synthesis ...
Chloé Dindault, Gilles Henri Roche, Martial Leyney, Tanguy Jousselin‐Oba, Laurence Vignau, Sylvain Chambon, Pierre‐Antoine Bonnardel, Sébastien Taillemite, Guillaume Wantz, Lionel Hirsch   +9 more
wiley   +1 more source

Unspecific Molecular Adsorption (UMA) Sample Preparation Method for Bottom‐up and Whole Protein Analysis: The Foundation

PROTEOMICS, EarlyView.
ABSTRACT The protein sample preparation methods for shotgun proteomics are nowadays well‐established unlike the ones for whole protein analysis. The goal of my work has been to create a simple methodology which provides a single uncomplicated sample preparation tool for these two fields. Nowadays the bulk of proteomics work is done using detergents for
Alexandre Zougman
wiley   +1 more source

Cross‐Linking Mass Spectrometry of the Antimicrobial Peptides Magainin 2 and PGLa Reveals Heterodimerization in Micellar Medium

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale In this study, we applied cross‐linking mass spectrometry (XL‐MS) to characterize the oligomeric states of a PGLa/magainin 2 mixture and gain insight into the heterodimerization previously suggested in the literature. Both peptides have shown a synergistic enhancement of activity when tested in antimicrobial assays; however, the ...
Emilie Hirschler, Elise Glattard, Nicolas Arnaud, Johana Chicher, Philippe Hammann, Emmanuelle Leize‐Wagner, Burkhard Bechinger, Noelle Potier   +7 more
wiley   +1 more source