Results 91 to 100 of about 30,487 (240)

Modulation of different K+ currents in Drosophila: a hypothetical role for the Eag subunit in multimeric K+ channels [PDF]

, 1993
We examined the role of the ether a go-go (eag) gene in modulation of K+ currents and the possibility of its protein product Eag as a subunit in the heteromultimeric assembly of K+ channels by voltage-clamp analysis of larval muscle membrane currents ...
Wu, C. F., Zhong, Y.
core   +1 more source

Alternative Splicing and Polyadenylation Contribute to the Generation of hERG1 C-terminal Isoforms

, 2010
The human ether-a-go-go-related gene 1 (hERG1) encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel. Several hERG1 isoforms with different N- and C-terminal ends have been identified.
Gong, Qiuming, Stump, Matthew R., Dunn, A. Russell, Deng, Vivianne, Zhou, Zhengfeng   +4 more
core  

ω-3 and ω-6 polyunsaturated fatty acids block HERG channels [PDF]

, 2005
11 pages, 7 figures.Dietary polyunsaturated fatty acids (PUFAs) have been reported to exhibit antiarrhythmic properties, which have been attributed to their availability to modulate Na(+), Ca(2+), and several K(+) channels.
Arias, Cristina, David, Miren, González, Teresa, Guizy, Miriam, Valenzuela, Carmen   +4 more
core   +2 more sources

Tumor cell-selective apoptosis induction through targeting of K_V10.1 via bifunctional TRAIL antibody

Molecular Cancer, 2011
Background The search for strategies to target ion channels for therapeutic applications has become of increasing interest. Especially, the potassium channel KV10.1 (Ether-á-go-go) is attractive as target since this surface protein is virtually not ...
Pardo Luis A, Stühmer Walter, Hartung Franziska   +2 more
doaj   +1 more source

An electrophysiological study of breast cancer cell HCC1937 [PDF]

, 2013
Potassium channels are considered as key molecules in the progression of several cancer types. Human ether a go-go (hEAG) potassium channels have been reported to possess oncogenic properties and to regulate the cell cycle. The present study was designed
TSUCHIDA Katsuharu, 土田 勝晴
core   +1 more source

Allitridi Inhibits Multiple Cardiac Potassium Channels Expressed in HEK 293 Cells [PDF]

, 2012
published_or_final_versio
Chen, KH, Deng, CY, Jin, MW, Li, GR, Liu, Y, Sun, H, Wu, W, Xu, XH, Yu, XY, Zhang, Y   +9 more
core   +1 more source

Effect of zeolite topology and reactor configuration on the direct conversion of CO2 to light olefins and aromatics [PDF]

, 2019
The direct transformation of CO2 into high-value-added hydrocarbons (i.e., olefins and aromatics) has the potential to make a decisive impact in our society. However, despite the efforts of the scientific community, no direct synthetic route exists today
Abou-Hamad, Edy, Caglayan, Mustafa, Cnudde, Pieter, De Wispelaere, Kristof, Dokania, Abhay, Dutta Chowdhury, Abhishek, Gascon, Jorge, Gevers, Lieven, Ould-Chikh, Samy, Ramirez, Adrian, Van Speybroeck, Veronique, Yarulina, Irina   +11 more
core   +1 more source

Characterization of the novel mutant A78T-HERG from a long QT syndrome type 2 patient: Instability of the mutant protein and stabilization by heat shock factor 1

Journal of Arrhythmia, 2016
Background: The human ether-a-go-go-related gene (HERG) encodes the α-subunit of rapidly activating delayed-rectifier potassium channels. Mutations in this gene cause long QT syndrome type 2 (LQT2).
Takehito Kondo, Ichiro Hisatome, Shouichi Yoshimura, Endang Mahati, Tomomi Notsu, Peili Li, Kazuhiko Iitsuka, Masaru Kato, Kazuyoshi Ogura, Junichiro Miake, Takeshi Aiba, Wataru Shimizu, Yasutaka Kurata, Shinji Sakata, Naoe Nakasone, Haruaki Ninomiya, Akira Nakai, Katsumi Higaki, Yasushi Kawata, Yasuaki Shirayoshi, Akio Yoshida, Kazuhiro Yamamoto   +21 more
doaj   +1 more source

Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy [PDF]

, 2017
Impairment of peripheral nerve function is frequent in neurometabolic diseases, but mechanistically not well understood. Here, we report a novel disease mechanism and the finding that glial lipid metabolism is critical for axon function, independent of ...
Asadollahi, Ebrahim, Baes, Myriam, Blanz, Judith, Brügger, Britta, de Hoz, Livia, Kassmann, Celia Michèle, Kleinecke, Sandra, Kungl, Theresa, Lüchtenborg, Christian, McGonigal, Rhona, Möbius, Wiebke, Naseri, Kobra, Nave, Klaus-Armin, Quintes, Susanne, Richert, Sarah, Sachsenheimer, Timo, Sereda, Michael W., Willison, Hugh   +17 more
core   +3 more sources

Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses

BMC Genetics, 2018
Background Patients with long QT syndrome due to rare loss-of-function mutations in the human ether-á-go-go-related gene (hERG) have prolonged QT interval, risk of arrhythmias, increased secretion of insulin and incretins and impaired glucagon response ...
Line Engelbrechtsen, Yuvaraj Mahendran, Anna Jonsson, Anette Prior Gjesing, Peter E. Weeke, Marit E. Jørgensen, Kristine Færch, Daniel R. Witte, Jens J. Holst, Torben Jørgensen, Niels Grarup, Oluf Pedersen, Henrik Vestergaard, Signe Torekov, Jørgen K. Kanters, Torben Hansen   +15 more
doaj   +1 more source