Relationship among amiodarone, new class III antiarrhythmics, miscellaneous agents and acquired long QT syndrome [PDF]
, 2008 Class III drugs prolong the QT interval by blocking mainly the delayed rectifier rapid potassium outward current (IKr), with little effect on depolarization. This K+ channel in encoded by the human ether-a-go-go-related gene (hERG).
Dubner, Sergio +7 more
core +1 more source
Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains [PDF]
, 2015 Voltage-gated channels open paths for ion permeation upon changes in membrane potential, but how voltage changes are coupled to gating is not entirely understood.
Barros de la Roza, Francisco +8 more
core +1 more source
Battery Energy, EarlyView.A photopolymerized porous gel polymer electrolyte shows superior ionic conductivity of 2.9 × 10−2 S cm−1, t+ of 0.88, high electrochemical stability of > 6 V, an initial capacity of 155 mAh g−1, an initial Coulombic efficiency of ~100%, and capacity retention of 99.9% after 100 cycles at 5 C.
Ali Zardehi‐Tabriz +4 more
wiley +1 more source
Chemistry &Biodiversity, EarlyView.ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves +3 more
wiley +1 more source
Expression of the ether-a-go-go (ERG) potassium channel in smooth muscle of the equine gastrointestinal tract and influence on activity of jejunal smooth muscle [PDF]
, 2003 James D. Lillich +5 more
openalex +1 more source
Gene Therapy in Cardiac Arrhythmias [PDF]
, 2006 Gene therapy has progressed from a dream to a bedside reality in quite a few human diseases. From its first application in adenosine deaminase deficiency, through the years, its application has evolved to vascular angiogenesis and cardiac arrhythmias.
Francis, Johnson +2 more
core
Identification of a New Interesting BAG3 Modulator Able to Disrupt Cancer‐Related Pathways
ChemMedChem, Accepted Article.Continuing our research aimed at discovering new BAG3 modulators as attractive anticancer drug candidates, we performed a screening campaign on an in‐house library, including compounds featuring a large variety of scaffolds. The obtained results induced us to focus on the triazole moiety and, following a stepwise structural refinement of the scaffold ...
Dafne Ruggiero +10 more
wiley +1 more source
N-linked glycosylation of ether á go-go potassium channels: effects on cell surface expression and functional properties [PDF]
, 2004 Joanna Napp
openalex +1 more source
Synthesis of New N,N′‐Diarylureas and Their Theoretical Study as Cannabinoid‐1 Receptor Inhibitors
ChemPlusChem, EarlyView.A series of new pyrazolo‐ and triazolo‐based N,N′‐diarylureas is synthesized following the triphosgene protocol in the last step. Density functional theory calculations and molecular docking provide strong evidence that all new compounds bind strongly to the cannabinoid‐1 (CB‐1) receptor, showing comparable results with the known allosteric CB‐1 ...
Eirini Tsemperlidou +4 more
wiley +1 more source
Covalent Organic Framework‐Based Photocatalysts from Synthesis to Applications
ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.This review explores the principles, synthesis, and reactions of COFs, highlighting their structural influences on photocatalytic activity. It presents key applications of COFs as photocatalyst. Various modification strategies for optimizing their efficiency are discussed.
Junxian Liu +5 more
wiley +1 more source