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Biophysical properties of zebrafish ether-à-go-go related gene potassium channels
Biochemical and Biophysical Research Communications, 2009The zebrafish is increasingly recognized as an animal model for the analysis of hERG-related diseases. However, functional properties of the zebrafish orthologue of hERG have not been analyzed yet. We heterologously expressed cloned ERG channels in Xenopus oocytes and analyzed biophysical properties using the voltage clamp technique.
Dierk Thomas +2 more
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Toxins interacting with ether-à-go-go-related gene voltage-dependent potassium channels
Toxicon, 2007The critical role that ether-à-go-go-related gene (erg) K(+) channels play in mating in Caenorhabditis elegans, neuronal seizures in Drosophila and cardiac action potential repolarization in humans has been well documented. Three erg genes (erg1, erg2 and erg3) have been identified and characterized.
Rita Restano-Cassulini
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Inhibition of Human Ether-A-Go-Go Potassium Channels by Cocaine
Molecular Pharmacology, 2001Cocaine is a potent cardiac stimulant and its use has been linked to life-threatening arrhythmias in humans. A prominent effect of cocaine in the heart is a suppression of the delayed-rectifier potassium current (I(K)) that is important for cardiac ...
M. E. O'leary
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Journal of Pharmacology and Experimental Therapeutics, 2001
Human ether-a-go-go-related gene (HERG) potassium channels are one primary target for the pharmacological treatment of cardiac arrhythmias by class III antiarrhythmic drugs. These drugs are characterized by high antiarrhythmic efficacy, but they can also
Dierk Thomas +2 more
exaly +2 more sources
Human ether-a-go-go-related gene (HERG) potassium channels are one primary target for the pharmacological treatment of cardiac arrhythmias by class III antiarrhythmic drugs. These drugs are characterized by high antiarrhythmic efficacy, but they can also
Dierk Thomas +2 more
exaly +2 more sources
Identification of Ether à Go-Go and Calcium-Activated Potassium Channels in Human Melanoma Cells
Journal of Membrane Biology, 1999Ion channels and intracellular Ca2+ are thought to be involved in cell proliferation and may play a role in tumor development. We therefore characterized Ca(2+)-regulated potassium channels in the human melanoma cell lines IGR1, IPC298, and IGR39 using electrophysiological and molecular biological methods.
R, Meyer +4 more
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Propranolol inhibits the human ether-a-go-go-related gene potassium channels
European Journal of Pharmacology, 2005Propranolol is a noncardioselective beta-adrenergic antagonist that has been recently reported to prolong the QTc interval on the surface electrocardiogram in humans when overdosed [Farhangi, V., Sansone, R.A. (2003). QTc prolongation due to propranolol overdose. Int. J. Psychiatry Med. 33, 201-202.].
Xiaozhou, Yao +5 more
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The Journal of Pharmacology and Experimental Therapeutics, 2002
Fluoxetine is a commonly prescribed antidepressant compound. Its action is primarily attributed to selective inhibition of the reuptake of serotonin (5-hydroxytryptamine) in the central nervous system. Although this group of antidepressant drugs is generally believed to cause fewer proarrhythmic side effects compared with tricyclic antidepressants ...
Dierk, Thomas +3 more
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Fluoxetine is a commonly prescribed antidepressant compound. Its action is primarily attributed to selective inhibition of the reuptake of serotonin (5-hydroxytryptamine) in the central nervous system. Although this group of antidepressant drugs is generally believed to cause fewer proarrhythmic side effects compared with tricyclic antidepressants ...
Dierk, Thomas +3 more
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Direct Block of Human Ether-a-go-go-Related Gene Potassium Channels by Caffeine
The Journal of Pharmacology and Experimental Therapeutics, 2006The human ether-a-go-go-related gene (hERG) potassium channel is expressed in a variety of cell types, including neurons, tumor cells, and cardiac myocytes. In the heart, it is important for repolarization of the cardiac action potential. Attenuation of hERG current can cause long QT syndrome and cardiac arrhythmias such as torsades de pointes ...
Cockerill, SL, Mitcheson, JS
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Molecular Determinants of Cocaine Block of Human Ether-á-go-go-Related Gene Potassium Channels
The Journal of Pharmacology and Experimental Therapeutics, 2006The use of cocaine causes cardiac arrhythmias and sudden death. Blockade of the cardiac potassium channel human ether-á-go-go-related gene (hERG) has been implicated as a mechanism for the proarrhythmic action of cocaine. hERG encodes the pore-forming subunits of the rapidly activating delayed rectifier K(+) channel (I(Kr)), which is important for ...
Jun, Guo, Hongying, Gang, Shetuan, Zhang
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