Results 151 to 160 of about 20,804 (181)
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Potassium channel ether à go-go mRNA expression in the spiral ligament of the rat
Hearing Research, 1999Identification of the K+ transporters located in the lateral wall of the cochlea is essential for a better understanding of the mechanisms by which a positive endocochlear potential and a high K+ concentration are achieved in endolymph. In this study, we have determined the distribution of the K+ channel rat ether à go-go (eag) mRNA in the cochlea ...
E, Lecain +4 more
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Inhibition of HumanEther-A-Go-GoPotassium Channels by Cocaine
Molecular Pharmacology, 2001Cocaine is a potent cardiac stimulant and its use has been linked to life-threatening arrhythmias in humans. A prominent effect of cocaine in the heart is a suppression of the delayed-rectifier potassium current (I(K)) that is important for cardiac repolarization.
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Mallotoxin Is a Novel Human Ether-a-go-go-Related Gene (hERG) Potassium Channel Activator
The Journal of Pharmacology and Experimental Therapeutics, 2006Human ether-a-go-go-related gene (hERG) encodes a rapidly activating delayed rectifier potassium channel that plays important roles in cardiac action potential repolarization. Although many drugs and compounds block hERG channels, activators of the channel have only recently been described.
Haoyu, Zeng +5 more
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Human ether-à-go-go-related potassium channel: exploring SAR to improve drug design
Drug Discovery Today, 2020hERG is best known as a primary anti-target, the inhibition of which is responsible for serious side effects. A renewed interest in hERG as a desired target, especially in oncology, was sparked because of its role in cellular proliferation and apoptosis.
Cavalluzzi MM +6 more
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Ether à-go-go Potassium Channels
2008Ion transport is crucial for maintaining proper cellular function; this important task is performed by several ▶membrane transporters including ▶ ion channels. Among other functions, ion channels play key roles in neurotransmission, muscle contraction, metabolism, sensory transduction, ▶ apoptosis, and cell cycle progression.
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Blockade of the human ether-a-go-go-related gene potassium channel by ketanserin.
Sheng li xue bao : [Acta physiologica Sinica], 2015In the present study, we investigated the inhibitory action of ketanserin on wild-type (WT) and Y652 mutant human ether-a-go-go-related gene (HERG) potassium channels expressed in Xenopus oocytes and the effects of changing the channel molecular determinants characteristics on the blockade with and without ketanserin intervention using standard two ...
Dan-Na, Tu +5 more
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The Journal of Pharmacology and Experimental Therapeutics, 2002
Several macrolides have been reported to cause QT prolongation and ventricular arrhythmias such as torsades de pointes. To clarify the underlying ionic mechanisms, we examined the effects of six macrolides on the human ether-a-go-go-related gene (HERG)-encoded potassium current stably expressed in human embryonic kidney-293 cells.
Walter A, Volberg +4 more
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Several macrolides have been reported to cause QT prolongation and ventricular arrhythmias such as torsades de pointes. To clarify the underlying ionic mechanisms, we examined the effects of six macrolides on the human ether-a-go-go-related gene (HERG)-encoded potassium current stably expressed in human embryonic kidney-293 cells.
Walter A, Volberg +4 more
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Journal of Pharmacological and Toxicological Methods, 2013
Drug-induced prolongation of the QT interval via block of the hERG potassium channel is a major cause of attrition in drug development. The advent of automated electrophysiology systems has enabled the detection of hERG block earlier in drug discovery.
Daniel J, Gillie +4 more
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Drug-induced prolongation of the QT interval via block of the hERG potassium channel is a major cause of attrition in drug development. The advent of automated electrophysiology systems has enabled the detection of hERG block earlier in drug discovery.
Daniel J, Gillie +4 more
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Halide Ion Effects on Human Ether-à-go-go Related Gene Potassium Channel Properties
ASSAY and Drug Development Technologies, 2013The human Ether-à-go-go related gene (hERG) potassium channel has been widely used to counter screen potential pharmaceuticals as a biomarker to predict clinical QT prolongation.
Haoyu, Zeng +5 more
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