Inhibition of the human ether‐a‐go‐go‐related gene (HERG) potassium channel by cisapride: affinity for open and inactivated states [PDF]
British Journal of Pharmacology, 1999 Cisapride is a prokinetic agent which has been associated with QT prolongation, torsades de pointes and cardiac arrest. The cellular mechanism for these observations is high affinity blockade of IKr (encoded by HERG). In a chronic transfection model using CHO‐K1 cells, cisapride inhibited HERG tail currents after a step to +25 mV with similar potency
B D, Walker +7 more
openaire +2 more sources
Two Types of K⁺ Channel Subunit, Erg1 and KCNQ2/3, Contribute to the M-Like Current in a Mammalian Neuronal Cell [PDF]
, 1999 The potassium M current was originally identified in sympathetic ganglion cells, and analogous currents have been reported in some central neurons and also in some neural cell lines.
Abogadie, FC +7 more
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Journal of Venomous Animals and Toxins including Tropical Diseases, 2018 Background Centruroides hirsutipalpus, of the family Buthidae, is a scorpion endemic to the Western Pacific region of Mexico. Although medically important, its venom has not yet been studied.
Laura L. Valdez-Velázquez +4 more
doaj +1 more source
The role of potassium channels in tumours of the gastrointestinal tract: a focus on the human ether‐à‐go‐go related gene 1 channels [PDF]
, 2022 Annarosa Arcangeli +3 more
openalex +1 more source
Identification of a COOH-terminal Segment Involved in Maturation and Stability of Human Ether-a-go-go-related Gene Potassium Channels [PDF]
Journal of Biological Chemistry, 2003 Mutations in the potassium channel encoded by the human ether-a-go-go-related gene (HERG) have been linked to the congenital long QT syndrome (LQTS), a cardiac disease associated with an increased preponderance of ventricular arrhythmias and sudden death.
Armin, Akhavan +2 more
openaire +2 more sources
Biomolecules & BiomedicineSecond-generation antipsychotics (SGAs) are frequently prescribed in psychiatry due to their efficacy and improved tolerability compared to first-generation agents.
Orhan Erkan +3 more
doaj +1 more source
Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells.
PLoS ONE, 2019 The alpha subunit of the voltage gated human ether-a-go-go-related (hERG) potassium channel regulates cell excitability in a broad range of cell lines.
Damodara Reddy Vaddi +5 more
doaj +1 more source
State dependent dissociation of HERG channel inhibitors [PDF]
, 2007 BACKGROUND AND PURPOSE: Inhibition of HERG channels prolongs the ventricular action potential and the QT interval with the risk of torsade de pointes arrhythmias and sudden cardiac death.
Auer, M. +6 more
core +2 more sources
Functional characterization of Kv11.1 (hERG) potassium channels split in the voltage-sensing domain [PDF]
, 2018 This work was supported by Grant BFU2015-66429-P (MINECO/FEDER UE) from the Spanish Ministerio de Economia y Competitividad and by regional subvention GRUPIN14-097 from the Principado de Asturias Science, Technology and Innovation Program 2013-2017, both
Barros de la Roza, Francisco +2 more
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Recent advances in our understanding of the structure and function of more unusual cation channels. [PDF]
, 2019 As their name implies, cation channels allow the regulated flow of cations such as sodium, potassium, calcium, and magnesium across cellular and intracellular membranes.
Brown, Brandon M +2 more
core +1 more source