Results 81 to 90 of about 22,847 (294)

10 Years Development of Potassium‐Ion Batteries

Advanced Materials, EarlyView.
Significant progress is made in PIBs over the past decade, but the improvements based on half‐cell testing, low mass loading, and low energy density are insufficient for practical applications. This review summarizes the challenges and strategies for PIBs, highlights the importance of further research focusing on full cells, and provides an analysis of
Mingnan Li, Caoyu Wang, Cheng Wang, Yanqiu Lyu, Jingxiu Wang, Shuixin Xia, Jianfeng Mao, Zaiping Guo   +7 more
wiley   +1 more source

Anesthetic drug midazolam inhibits cardiac human ether-à-go-go-related gene channels: mode of action

Drug Design, Development and Therapy, 2015
Nadine Vonderlin,1 Fathima Fischer,1 Edgar Zitron,1,2 Claudia Seyler,1 Daniel Scherer,1 Dierk Thomas,1,2 Hugo A Katus,1,2 Eberhard P Scholz1 1Department of Internal Medicine III, University Hospital Heidelberg, 2German Centre for Cardiovascular ...
Vonderlin N, Fischer F, Zitron E, Seyler C, Scherer D, Thomas D, Katus HA, Scholz EP,   +7 more
doaj  

The role of potassium channels in tumours of the gastrointestinal tract: a focus on the human ether‐à‐go‐go related gene 1 channels

The Journal of Physiology, 2022
AbstractPotassium channels are often dysregulated in tumours of the gastrointestinal (GI) tract. Among them, the voltage‐dependent channel KV11.1, also known as human ether‐à‐go‐go related gene 1 (hERG1), is frequently expressed in tumours and precancerous lesions of the GI tract.
Arcangeli, Annarosa, Duranti, Claudia, Iorio, Jessica, Lastraioli, Elena   +3 more
openaire   +2 more sources

Over Tenfold Increase in Current Amplification Due to Anisotropic Polymer Chain Alignment in Organic Electrochemical Transistors

Advanced Materials, EarlyView.
How to boost the IDS output of an OECT? Anisotropic polymer alignment along the channel direction enables a 13‐fold increase in IDS. Such channel engineering opens the door to unprecedented signal amplification (here gmL/Wd = 2 580 S cm−1 with a PBTTT‐backbone bearing single‐ether side chains), faster ON/OFF switching, and improved stability for the ...
Olivier Bardagot, Pablo Durand, Shubhradip Guchait, Han‐Yan Wu, Isabelle Heinzen, Wissal Errafi, Victor Bouylout, Alessandra Pistillo, Chi‐Yuan Yang, Gonzague Rebetez, Priscila Cavassin, Badr Jismy, Julien Réhault, Simone Fabiano, Martin Brinkmann, Nicolas Leclerc, Natalie Banerji   +16 more
wiley   +1 more source

Identification of undecylenic acid as EAG channel inhibitor using surface plasmon resonance-based screen of KCNH channels

BMC Pharmacology and Toxicology, 2019
Background KCNH family of potassium channels is responsible for diverse physiological functions ranging from the regulation of neuronal excitability and cardiac contraction to the regulation of cancer progression. KCNH channels contain a Per-Arn-Sim (PAS)
Ze-Jun Wang, Purushottam B. Tiwari, Aykut Üren, Tinatin I. Brelidze   +3 more
doaj   +1 more source

A Perspective on Pathways Toward Commercial Sodium‐Ion Batteries

Advanced Materials, EarlyView.
Comprehensive analysis of the existing and prospective sodium‐ion battery (SIB) systems unveils that a wider application of SIBs should primarily focus on i) regulating the composition, morphology, surface chemistry, safety performance, and production feasibility of mainstream cathodes, ii) enhancing the high‐voltage stability, film formation ability ...
Zehao Cui, Chen Liu, Arumugam Manthiram
wiley   +1 more source

State dependent dissociation of HERG channel inhibitors [PDF]

, 2007
BACKGROUND AND PURPOSE: Inhibition of HERG channels prolongs the ventricular action potential and the QT interval with the risk of torsade de pointes arrhythmias and sudden cardiac death.
Auer, M., Berjukow, S., Hering, S., Hohaus, A., Huber, C., Stork, D., Timin, E.N.   +6 more
core   +2 more sources

De Novo Design of Integrin α5β1 Modulating Proteins to Enhance Biomaterial Properties

Advanced Materials, EarlyView.
NeoNectins are de novo‐designed miniproteins that selectively bind and stabilize the extended open form of integrin α5β1. When grafted onto biomaterials including hydrogel and titanium, they promote cell attachment and spreading in vitro and promoting tissue integration and bone growth in animal models, demonstrating broad potential for regenerative ...
Xinru Wang, Jordi Guillem‐Marti, Saurav Kumar, David S. Lee, Daniel Cabrerizo‐Aguado, Rachel Werther, Kevin Alexander Estrada Alamo, Yan Ting Zhao, Adam Nguyen, Irina Kopyeva, Buwei Huang, Jing Li, Yuxin Hao, Xinting Li, Aritza Brizuela‐Velasco, Analisa Murray, Stacey Gerben, Anindya Roy, Cole A. DeForest, Timothy Springer, Hannele Ruohola‐Baker, Jonathan A. Cooper, Melody G. Campbell, Jose Maria Manero, Maria‐Pau Ginebra, David Baker   +25 more
wiley   +1 more source

Facilitation of I Kr current by some hERG channel blockers suppresses early afterdepolarizations. [PDF]

, 2019
Drug-induced block of the cardiac rapid delayed rectifying potassium current (I Kr), carried by the human ether-a-go-go-related gene (hERG) channel, is the most common cause of acquired long QT syndrome.
Chen, I-Shan, Furutani, Kazuharu, Handa, Kenichiro, Kurachi, Yoshihisa, Sack, Jon T, Tsumoto, Kunichika, Yamakawa, Yuko   +6 more
core   +1 more source

CASK regulates CaMKII autophosphorylation in neuronal growth, calcium signaling, and learning [PDF]

, 2013
Calcium (Ca2+)/calmodulin (CaM)-dependent kinase II (CaMKII) activity plays a fundamental role in learning and memory. A key feature of CaMKII in memory formation is its ability to be regulated by autophosphorylation, which switches its activity on and ...
Gillespie, John M, Hodge, James J L
core   +2 more sources