Results 51 to 60 of about 1,519,760 (306)

The Ethics of the Vietnam War [PDF]

open access: yes, 2017
Although the Vietnam Conflict was not conducted in an entirely ethical manner, the war provided a tangible example of the extent of Kennan’s containment theory and its effect on the United States in the twentieth ...
Ewing, Samuel
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Multi-agent utility theory for ethical conflict resolution

open access: yesJournal of Telecommunications and Information Technology, 2002
In this paper we try to construct a two-attribute group disutility function for two conflicting decision makers, taking into account the property of utility independence and/or convex dependence between them.
Hiroyuki Tamura
doaj   +1 more source

A Voting-Based System for Ethical Decision Making [PDF]

open access: yes, 2018
We present a general approach to automating ethical decisions, drawing on machine learning and computational social choice. In a nutshell, we propose to learn a model of societal preferences, and, when faced with a specific ethical dilemma at runtime ...
Awad, Edmond   +6 more
core   +3 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

The patient suicide attempt – An ethical dilemma case study

open access: yesInternational Journal of Nursing Sciences, 2015
Case description: Nurses face more and more ethical dilemmas during their practice nowadays, especially when they are taking care of the patient at end of life stage. The case study demonstrates an ethical dilemma when nursing staff are taking care of an
Lin Jie
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

A Comparison of the Metaphysical Egoism of ʿAllāma Ṭabāṭabāʾī With Egoistic Theories in Ethics [PDF]

open access: yesآموزه‌‌های فلسفه اسلامي
The discussion of egoism versus altruism, or benevolence, is a significant topic in contemporary ethical philosophy. Egoism is categorized into psychological egoism and ethical egoism. From the perspective of psychological egoism, as a descriptive theory,
Ḥamīd Ḥassanī, Donyā Ḥamīdī
doaj   +1 more source

Institutionalising ethical cultures: an investigation of formal organisational approaches [PDF]

open access: yes, 2006
This thesis examined the institutionalisation of ethics within Australian organisations. A particular focus is the role of the strategic apex, or executive level of the organisation, in establishing the environment in which an ethical culture can develop.
Segon, Michael John
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

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