Results 51 to 60 of about 1,513,082 (305)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Multi-agent utility theory for ethical conflict resolution
Journal of Telecommunications and Information Technology, 2002 In this paper we try to construct a two-attribute group disutility function for two conflicting decision makers, taking into account the property of utility independence and/or convex dependence between them.
Hiroyuki Tamura
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
The patient suicide attempt – An ethical dilemma case study
International Journal of Nursing Sciences, 2015 Case description: Nurses face more and more ethical dilemmas during their practice nowadays, especially when they are taking care of the patient at end of life stage. The case study demonstrates an ethical dilemma when nursing staff are taking care of an
Lin Jie
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Institutionalising ethical cultures: an investigation of formal organisational approaches [PDF]
, 2006 This thesis examined the institutionalisation of ethics within Australian organisations. A particular focus is the role of the strategic apex, or executive level of the organisation, in establishing the environment in which an ethical culture can develop.
Segon, Michael John
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Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
A Comparison of the Metaphysical Egoism of ʿAllāma Ṭabāṭabāʾī With Egoistic Theories in Ethics [PDF]
آموزههای فلسفه اسلاميThe discussion of egoism versus altruism, or benevolence, is a significant topic in contemporary ethical philosophy. Egoism is categorized into psychological egoism and ethical egoism. From the perspective of psychological egoism, as a descriptive theory,
Ḥamīd Ḥassanī, Donyā Ḥamīdī
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A Voting-Based System for Ethical Decision Making [PDF]
, 2018 We present a general approach to automating ethical decisions, drawing on machine learning and computational social choice. In a nutshell, we propose to learn a model of societal preferences, and, when faced with a specific ethical dilemma at runtime ...
Awad, Edmond +6 more
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Max Weber on Politics, Reason, and the Clash of Values and Approaches to Ethics [PDF]
, 2019 This article investigates how Max Weber’s theory of value conflict is connected to his realist understanding of politics and how he conceives the relation of politics and ethics. This investigation also covers Weber’s views on the argumentative limits of
Dr Knoll, Manuel
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