Results 111 to 120 of about 866,840 (339)

Controvérsias sobre a revisão ética de pesquisas em ciências humanas e sociais pelo Sistema CEP/Conep

Revista Bioética
O comitê de ética em pesquisa tem como função revisar todas as pesquisas envolvendo seres humanos realizadas no Brasil, o que tem suscitado controvérsias sobre a revisão ética de pesquisas em ciências humanas e sociais. O objetivo deste artigo é discutir
Adriana Silva Barbosa, Carlos Montero Corrales, Marcos Silbermann   +2 more
doaj   +1 more source

L'éthique médicale appliquée aux sciences humaines et sociales : pertinence, limites, enjeux et ajustements nécessaires [PDF]

, 2008
International audienceMedical research-ethics applied to social sciences: relevance, limits, issues and necessary adjustments Social sciences are concretely concerned by the ethics of medical research when they deal with topics related to health, since ...
Desclaux, Alice
core   +2 more sources

From the principles of genomic data sharing to the practices of data access committees [PDF]

, 2015
Sharing genomic research data through controlled-access databases has increased in recent years. Policymakers and funding organizations endorse genomic data sharing in order to optimize the use of public funds and to increase the statistical power of ...
Borry, Pascal, Knoppers, Bartha Maria, Shabani, Mahsa   +2 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The ethics of doing research with young drug users [PDF]

, 2009
Investigations into young people with problematic substance use raise complex issues for institutional ethics committees. The inclusion of people under 18 years old in research requires significant work in preparing applications that will meet the ...
Daley, K
core  

Beneficial Artificial Intelligence Coordination by means of a Value Sensitive Design Approach [PDF]

, 2019
This paper argues that the Value Sensitive Design (VSD) methodology provides a principled approach to embedding common values in to AI systems both early and throughout the design process.
Umbrello, Steven
core   +2 more sources

Incorporating ethical principles into clinical research protocols: a tool for protocol writers and ethics committees

Journal of Medical Ethics, 2016
A novel Protocol Ethics Tool Kit (‘Ethics Tool Kit’) has been developed by a multi-stakeholder group of the Multi-Regional Clinical Trials Center of Brigham and Women's Hospital and Harvard.
Rebecca Li, M. Wacholtz, Mark Barnes, Liam Boggs, Susan Callery-D’Amico, A. Davis, Alla Digilova, D. Forster, K. Heffernan, Maeve Luthin, H. Lynch, Lindsay McNair, Jennifer E. Miller, Jacquelyn Murphy, L. V. Van Campen, Marc Wilenzick, Delia Wolf, Cris Woolston, Carmen E. Aldinger, B. Bierer   +19 more
semanticscholar   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Differences and structural weaknesses of institutional mechanisms for health research ethics: Burkina Faso, Palestine, Peru, and Democratic Republic of the Congo

BMC Medical Ethics, 2018
Background Regardless of national contexts, the institutions responsible for research ethics, founded on international regulations, are all expected to be structured and to operate in a common way.
N’koué Emmanuel Sambiéni
doaj   +1 more source

Més de 25 anys fent camí. Ètica i Treball Social [PDF]

, 2011
This article contains the main data from a research study on the ethics and deontology committee of the Association of Social Workers of Catalonia. It describes the history of the committee, some factual information about the consultations addressed to
Alonso, Emilia, Bassets Marill, Josefina, Plans Ferrer, Montserrat, Rubiol, Glòria   +3 more
core