Results 131 to 140 of about 866,840 (339)

Physical activity counselling in Ireland: a survey of doctors’ knowledge, attitudes and self-reported practice

BMJ Open Sport & Exercise Medicine, 2019
Objective Physical activity (PA) counselling has been shown to raise awareness of the importance of PA and to increase the rate of PA engagement among patients.
Lucia Prihodova, Sarah O'Brien, Mairéad Heffron, Peter Wright   +3 more
doaj   +1 more source

Communicating Qualitative Research Study Designs to Research Ethics Review Boards [PDF]

, 2011
Researchers using qualitative methodologies appear to be particularly prone to having their study designs called into question by research ethics or funding agency review committees.
Ells, Carolyn
core   +1 more source

Can an ethics officer role reduce delays in research ethics approval? A mixed-method evaluation of an improvement project. [PDF]

, 2016
OBJECTIVE: Frustration continues to be directed at delays in gaining approvals for undertaking health research in the UK. We aimed to evaluate the impact of an ethics officer intervention on rates of favourable opinions (approval) and provisional ...
Al-Shahi Salman, Rustam, Dixon-Woods, Mary, Foy, Chris, Hayden, Charlotte, Schroter, Sara, Tebbutt, Stephen   +5 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Informed consent to HIV cure research [PDF]

, 2017
Trials with highly unfavourable risk–benefit ratios for participants, like HIV cure trials, raise questions about the quality of the consent of research participants.
Bromwich, Danielle, Millum, Joseph R.
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Research Ethics Committees (RECs) and the Creaking Piers of Peer Review [PDF]

[No abstract][No keywords]
John Holmwood
core  

Research ethics committees : a short systematic study of national and international literature [PDF]

, 2013
Indrodução: No Brasil, a efetivação dos Comitês de Ética em Pesquisas (CEPs) ocorreu com a Resolução 196/96 do Conselho Nacional de Saúde (CNS), cuja publicação despertou interesse de estudos sobre a aplicação de suas diretrizes e atuação dos CEPs ...
Araujo, Tereza Cristina Cavalcanti Ferreira de, Jácome, Marília de Queiroz Dias   +1 more
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The 50th Anniversary of the Declaration of Helsinki: Progress but Many Remaining Challenges [PDF]

, 2013
Since 1964, through 7 revisions, the World Medical Association’s Declaration of Helsinki has stood as an important statement regarding the ethical principles guiding medical research with human participants.
Millum, J.
core