Results 121 to 130 of about 478,794 (298)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

THE ROLE OF GOOD PRACTICES IN THE MANAGEMENT OF ETHICAL PROGRAMS IN HOSPITAL ESTABLISHMENTS. A FURTHER STEP FROM ETHICS COMMITTEES [PDF]

open access: yesAnalele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2012
This article is a review of both the functions and roles played by ethics committees in hospital establishments,and respectively of the challenges they are confronted with, in the general context of activities concerned withorganizational ethics ...
AGHEORGHIESEI (CORODEANU) DANIELA-TATIANA
doaj  

The ESRC's 2010 Framework for Research Ethics: Fit for Research Purpose? [PDF]

open access: yes
The ESRC\'s (2010) Framework for Research Ethics extends the remit of its 2005 research ethics framework in three significant ways: the system is to be fully mandatory and it will no longer possible to make the case that no out of the ordinary ethical ...
Liz Stanley, Sue Wise
core  

Barriers and enablers to optimal consumer involvement in research: the perspectives of health and medical researchers in the UK [PDF]

open access: yes, 2011
Numerous reasons exist for involving consumers in research, falling mainly into three categories: moral/ethical, methodological, and political. The moral and ethical reasons for involving consumers in research centre on concepts of rights, citizenship ...
Ward, Paul Russell
core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Navigating the Process of Ethical Approval: A methodological note

open access: yesGrounded Theory Review: An International Journal, 2010
Classic grounded theory (CGT) methodology is a general methodology whereby the researcher aims to develop an emergent conceptual theory from empirical data collected by the researcher during the research study.
Eileen Carey, RNID, BSc. (hons), MSc.
doaj   +2 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

ETHICS COMMITTEES AND EXTERNALLY-SPONSORED RESEARCH IN IRAN (2002-2003)

open access: yesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2006
Background: Globally, there have been considerable debates on the ethical conduct and review of collaborative international research. One of the great challenges is to conduct clinical trials in developing countries as Externally-Sponsored Researches ...
B Larijani,   +9 more
doaj  

L'éthique médicale appliquée aux sciences humaines et sociales : pertinence, limites, enjeux et ajustements nécessaires [PDF]

open access: yes, 2008
International audienceMedical research-ethics applied to social sciences: relevance, limits, issues and necessary adjustments Social sciences are concretely concerned by the ethics of medical research when they deal with topics related to health, since ...
Desclaux, Alice
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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