Results 201 to 210 of about 246,567 (336)

USP11‐PGAM5 Axis Promotes Neurotoxic Astrocyte Reactivity by Aggravating the mtDNA‐cGAS‐STING Pathway After Intracerebral Hemorrhage

open access: yesAdvanced Science, Volume 13, Issue 1, 5 January 2026.
This study reveals that the deubiquitinase USP11 stabilizes PGAM5, triggering neurotoxic astrocyte transformation after intracerebral hemorrhage. PGAM5 promotes mPTP opening and Drp1 dephosphorylation, synergistically amplifying mtDNA leakage into the cytosol and leading to cGAS–STING hyperactivation.
Jiaqing He   +10 more
wiley   +1 more source

Flow Cytometry: Advances, Challenges and Trends

open access: yesBioEssays, Volume 48, Issue 1, January 2026.
Recent advances in flow cytometry span hardware, data processing, and AI‐driven analytics. Emerging modalitiesincluding spectral, imaging, mass, and nano/EV cytometryenable higher‐parameter and small‐particle detection. Integrated machine learning drives a shift from manual gating toward automated multi‐omics workflows.
J. Paul Robinson   +2 more
wiley   +1 more source

Amphiphilic Cu(II) Oxacyclen Complexes: From Oxidative Cleavage to Condensation of DNA

open access: yesChemBioChem, Volume 27, Issue 2, January 2026.
Monoalkylated Cu(II) oxacyclen complexes show a dual DNA effect: shorter alkyl chains enable ROS‐mediated DNA cleavage, whereas longer chains cause strong DNA condensation/aggregation. Thus, chain length controls activity. Using circular dichroism, UV/visible and fluorescence spectroscopy, atomic force microscopy, dynamic light scattering, and ...
Olga Verbitsky   +5 more
wiley   +1 more source

The binding of polyamines and of ethidium bromide to tRNA

open access: green, 1975
Ted T. Sakai   +4 more
openalex   +2 more sources

Selection and Characterization of SARS‐CoV‐2 Spike Binding Clickmers

open access: yesChemBioChem, Volume 27, Issue 1, January 2026.
Split‐combine click‐systematic evolution of ligands by exponential enrichment against wild‐type SARS‐CoV‐2 spike glycoprotein yields benzofuran‐ and indole‐functionalized DNA aptamers (clickmers). These clickmers retain specific binding to multiple variants with nanomolar affinity, and the 31 nt indole‐functionalized truncate T2 retains binding to ...
Nima Moradzadeh   +7 more
wiley   +1 more source

Exploring the RNA‐Binding Potential of Three‐Dimensional Cyanines Derived From [2.2]Paracyclophane: A Structure–Property Relationship

open access: yesChemBioChem, Volume 27, Issue 1, January 2026.
Turn‐on polymethine dyes with a 3D [2.2]paracyclophane core selectively bind single‐stranded RNA over duplex regions, exhibiting higher specificity than flat benzene analogs. This study reports the design, synthesis, and structure–property analysis of an original family of three‐dimensional cyanine dyes based on the [2.2]paracyclophane (pCp) scaffold ...
Rongyu Sun   +5 more
wiley   +1 more source

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