Results 91 to 100 of about 5,139,071 (291)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

'Ethnic Conflictt in Colombia? The Impact of the Unit of Analysis and the Area of Study on Recognition of Wars as Ethnicc

open access: yesSSRN Electronic Journal, 2013
Reflecting on methodology means thinking about the decisions a researcher makes when approaching the subject of study, the questions posed and the concepts embraced. The use of any methods should not overlook the epistemological and ontological assumptions underlying the selection of a particular methodology, though this is not often explicitly ...
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Ethnic Studies Newsletter Vol. 3 No. 1

open access: yes, 1982
Seven page newsletter from the Ethnic Studies department dated October 1982. Newsletter is Volume 3, Number 1. Newsletter includes Feature on Dr. Herbert Aptheker; Feature on Dr.
Ethnic Studies Department;
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Ethnic Studies Newsletter Vol. 4 No. 1

open access: yes, 1983
Six page newsletter from the Ethnic Studies department dated October 1983. Newsletter is Volume 4, Number 1. Newsletter includes Features on Dr. Kate Conway McDavis; News Items on Northern California Regional Conference, Research Project on Japanese ...
Ethnic Studies Department;
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Ethnobotanical studies on rice landraces under on-farm conservation in Xishuangbanna of Yunnan Province, China

open access: yesJournal of Ethnobiology and Ethnomedicine
Background A complex interaction and mutual influence exists among landscapes, cultures, and landraces, with rice culture being a typical embodiment of this relationship.
Fei Wang   +6 more
doaj   +1 more source

Home - About - Disclaimer - Privacy