Results 81 to 90 of about 5,139,071 (291)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Ethnic Studies Newsletter Vol. 5 No. 1
, 1984 Six page newsletter from the Ethnic Studies department dated Fall 1984. Newsletter is Volume 5, Number 1. Newsletter includes Feature on Dr. Joyce E. King; news items on Progress on S.C.
Ethnic Studies Department;
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ON SOME ETHNIC HOUSING AREAS OF CĂLĂRAŞI
, 2013 The paper makes a general description of poverty areas inhabited by Roma communities in Călărași, Romania and tries to put them into a general context of urban geography. In particular it aims to illustrate the urban setting, the housing conditions of the dwellers, the dynamics and the formation of three ethnic and poverty enclaves that display to a ...
openaire +2 more sources
Ethnic Dimensions of Suburbanisation in Estonia [PDF]
Large scale suburbanisation is a relatively recent phenomenon in East Central Europe and responsible for major socio-spatial changes in metropolitan areas. Little is known about the ethnic dimensions of this process.
van Ham, Maarten +3 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
People and NatureLarge old trees are important ecological entities in human settlements, providing cultural values and ecological services that are threatened by current and future changes in global climate, land use and disturbance regimes.
Zhuo Cheng +5 more
doaj +1 more source
Frontiers in ImmunologyIntegrin β3 (ITGB3) functions as a pivotal transmembrane receptor mediating bidirectional signalling between cells and the extracellular matrix within the tumour microenvironment (TME).
Lianyi Peng +9 more
doaj +1 more source
Spatial and Temporal Patterns of Ecological Connectivity in the Ethnic Areas, Sichuan Province, China. [PDF]
Int J Environ Res Public Health, 2022 Guo S, Deng X, Ran J, Ding X.
europepmc +1 more source