Results 81 to 90 of about 213,542 (262)
SSRN Electronic Journal, 2013 Reflecting on methodology means thinking about the decisions a researcher makes when approaching the subject of study, the questions posed and the concepts embraced. The use of any methods should not overlook the epistemological and ontological assumptions underlying the selection of a particular methodology, though this is not often explicitly ...
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The Relationship Between Psychological Capital and Teacher Career Commitment in Ethnic Areas of China: The Mediating Effects of Gratitude and Career Well-Being. [PDF]
Front Psychol, 2021 Hu D, Zhou T, Zhou K, Deng F.
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The Paradox of Safe Areas in Ethnic Civil Wars [PDF]
Global Responsibility to Protect, 2018 Safe areas established by powerful states can improve short-term civilian protection during ethnic civil wars. Paradoxically, however, they may worsen the plight of vulnerable civilians over the medium term. This can occur in three ways. First, when safe areas encompass sizeable territories within a broader conflict zone, they may reduce incentives for
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Journal of Ethnobiology and EthnomedicineBackground A complex interaction and mutual influence exists among landscapes, cultures, and landraces, with rice culture being a typical embodiment of this relationship.
Fei Wang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
ETHNIC CONCENTRATION AREAS IN NEIGHBOURHOOD PERSPECTIVE IN ENSCHEDE, THE NETHERLANDS
Indonesian Journal of Geography, 2013 Previous studies suggest that measuring ethnic segregation at a disaggregated level allows capturing variability of ethnic concentration areas within a city. However, many ignore the relative locations of each neighbourhood to identify ethnic concentration areas. It causes misidentification of ethnic concentration areas.
Wulan, Rian +2 more
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