Results 71 to 80 of about 213,542 (262)

ON SOME ETHNIC HOUSING AREAS OF CĂLĂRAŞI

, 2013
The paper makes a general description of poverty areas inhabited by Roma communities in Călărași, Romania and tries to put them into a general context of urban geography. In particular it aims to illustrate the urban setting, the housing conditions of the dwellers, the dynamics and the formation of three ethnic and poverty enclaves that display to a ...
openaire   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Tissue-specific biosynthesis and spatial distribution of xanthones in Garcinia oblongifolia revealed by integrated metabolomic and full-length transcriptomic analyses

BMC Genomics
Background The medicinal plant Garcinia oblongifolia (Clusiaceae), widely used in the Lingnan area of southern China, exhibits notable anti-inflammatory, analgesic, antimyatrophy, antibacterial, and antitumor properties.
Yi Zhang, Ruiqi Zhang, Baiyun Wang, Xinyi Dai, Xiaoyi Yan, Xinyue Liu, Lu Yang, Bo Liu, Honglei Jin, Liya Liu, Yue Liu   +10 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Integrin β3: structural functions, tumour microenvironment regulatory roles and targeted intervention strategies

Frontiers in Immunology
Integrin β3 (ITGB3) functions as a pivotal transmembrane receptor mediating bidirectional signalling between cells and the extracellular matrix within the tumour microenvironment (TME).
Lianyi Peng, Fuxian Liu, Yue Yang, Liying Zhang, Shuangsheng Huang, Fei Zhao, Caili Li, Jiyu Huang, Zihan Wang, Jianxin He   +9 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Traditional knowledge promotes the protection of large old trees: A case from China's richest biocultural diversity area

People and Nature
Large old trees are important ecological entities in human settlements, providing cultural values and ecological services that are threatened by current and future changes in global climate, land use and disturbance regimes.
Zhuo Cheng, Xiaoping Lu, Yanxiao Fan, Qingjiang Cui, Xian Hu, Chunlin Long   +5 more
doaj   +1 more source