Results 91 to 100 of about 186,917 (199)

Endogenous melatonin partial metabolic clearance as a potential endogenous marker of CYP1A2 activity

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2899-2908, August 2026.
Aims Cytochrome P450 1A2 (CYP1A2) exhibits substantial interindividual variability, necessitating appropriate phenotyping strategies for personalized pharmacotherapy. This study evaluated endogenous melatonin partial metabolic clearance (CLm(MEL)), calculated from urinary 6‐hydroxymelatonin (6‐O‐MEL) excretion and plasma melatonin (MEL) exposure, as a ...
Akitomo Yokokawa, Hayato Shimazaki, Shunji Igarashi, Yoshiki Tagawa, Naoki Hisada, Hiromi Shibasaki   +5 more
wiley   +1 more source

Development of a Column-Switching HPLC-MS/MS Method and Clinical Application for Determination of Ethyl Glucuronide in Hair in Conjunction with AUDIT for Detecting High-Risk Alcohol Consumption

Pharmaceutics, 2018
It is critical to assess the severity of alcohol consumption in certain diseases such as alcohol liver disease and alcohol addiction. Ethyl glucuronide (EtG) is a highly stable metabolite of ethanol in hair; thus, it was proposed as a long-term ...
Yeon Gyeong Kim, Jihye Hwang, Hwakyung Choi, Sooyeun Lee   +3 more
doaj   +1 more source

Cardiac biomarkers and echocardiographic measurements according to different levels of ethyl glucuronide in hair.

, 2019
Cardiac biomarkers and echocardiographic measurements according to different levels of ethyl glucuronide in hair.
Emmanouil Charitakis (4955731), Robert Kronstrand (6577166), Jan-Erik Karlsson (3515990), Neshro Barmano (6577163), Fredrik H. Nystrom (490261), Ulla Walfridsson (6577169), Håkan Walfridsson (6577172)   +6 more
core   +1 more source

Representative UPLC–MS/MS chromatograms of 5-O-glucuronide-GL-V9 and IS.

, 2023
(A) blank plasma; (B) calibration standard at 50ng/ml; (C) Beagle plasma sample obtained at 15min after an intravenous administration of GL-V9 at 1.5mg/kg (left standard for 5-O-glucuronide-GL-V9, right standard for IS).
Guanlan Liu (6494702), Qinglong Guo (533364), Yuxin Zhou (496784), Xuefeng Zhang (336127), Zechun Sang (16052993)   +4 more
core   +1 more source

Evaluation and clinical application of ethyl glucuronide and ethyl sulfate as biomarkers for recent alcohol consumption

, 2011
In recent years, there has been a growing interest in various biochemical markers for detecting acute and chronic alcohol consumption. Biochemical markers for acute and chronic drinking play important roles in detecting alcohol use, abuse and dependence ...
Helen Dahl (18638704)
core   +1 more source

Decrease of ethyl glucuronide concentrations in hair after exposure to chlorinated swimming pool water. [PDF]

, 2017
The direct alcohol marker ethyl glucuronide (EtG) is widely used for the assessment of alcohol consumption behavior and abstinence monitoring by hair analysis. We investigated the influence of chlorinated swimming pool water on EtG concentrations in hair
Weinmann, Wolfgang, Susanne Nussbaumer, Luginbühl, Marc, Nussbaumer, Susanne, Wolfgang Weinmann, Marc Luginbühl   +5 more
core   +1 more source

Supplementary Figure 7 from Contribution of OATP1B1 and OATP1B3 to the Disposition of Sorafenib and Sorafenib-Glucuronide

, 2013
PDF file - 37K, Estradiol-17β-D-glucuronide transport in HEK293 OATP1B1 variant cells.
Eric I. Zimmerman (425623), Shuiying Hu (10268480), Alice A. Gibson (10268477), Alex Sparreboom (236030), Lie Li (372905), Shelley J. Orwick (14920496), Sharyn D. Baker (14918718), Justin L. Roberts (14986248)   +7 more
core   +1 more source

Simultaneous Determination of Chlorogenic Acid Isomers and Metabolites in Rat Plasma Using LC-MS/MS and Its Application to A Pharmacokinetic Study Following Oral Administration of Stauntonia Hexaphylla Leaf Extract (YRA-1909) to Rats

Pharmaceutics, 2018
Stauntonia hexaphylla leaf extract (YRA-1909), which is widely used for the antirheumatic properties, has been under phase 2 clinical trials in patients with rheumatoid arthritis since April 2017.
Won-Gu Choi, Ju-Hyun Kim, Dong Kyun Kim, Yongnam Lee, Ji Seok Yoo, Dae Hee Shin, Hye Suk Lee   +6 more
doaj   +1 more source

A Positive Urine Alcohol with Negative Urine Ethyl-Glucuronide [PDF]

Laboratory Medicine, 2018
Urine ethanol is a common finding in urine drug-screening results. An unexpected finding of alcohol in urine can have serious implications for patients who have committed to pain-management contracts or are being counseled for substance abuse. Although laboratory screening for urine ethanol is highly specific and sensitive, the source of the ethanol ...
openaire   +2 more sources

Determination of ethyl glucuronide in hair

, 2013
Ethyl glucuronide (EtG) is a minor metabolite of alcohol that can be detected in hair. The objective of this study was to develop a validated method for the detection of EtG in hair samples.
Bell, Stephanie
core