Results 81 to 90 of about 197,866 (198)
Exploring phytochemicals and pharmacological properties of Populus × tomentiglandulosa
Populus × tomentiglandulosa (PT), a tree endemic to Korea, shows promising potential as a natural therapeutic agent owing to its potent anti-inflammatory properties. However, the isolation and analysis of phytochemical compounds in PT and related species
Hak-Dong Lee +10 more
doaj +1 more source
Riluzole metabolism guided the design of benzo[d]thiazole inhibitors of casein kinase 1 delta (CK1δ), a kinase linked to amyotrophic lateral sclerosis (ALS). Docking supported ATP site recognition by the hydroxylamine metabolite and hydrazine analogues, leading to compounds showing improved potency and retained predicted blood brain barrier ...
Simone Adorinni +18 more
wiley +1 more source
Ethyl Glucuronide Elimination Kinetics in Fingernails and Comparison to Levels in Hair
Measurement of ethyl glucuronide (EtG) in nail, as a biomarker for alcohol intake, has recently been suggested as alternative to measurement in hair. The aim of this study was to compare levels of EtG in nail and hair, and to investigate the elimination ...
Jørg Mørland +13 more
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Phytochemical and biological profiling of Launaea mucronata aerial parts reveals six bioactive constituents alongside potent antioxidant and antidiabetic properties. The hydroethanolic extract inhibits key carbohydrate‐metabolizing enzymes and exerts marked hypoglycemic and insulinotropic effects with histological restoration of metabolic organs in ...
Amira Mohamed +5 more
wiley +1 more source
Background: The quantitative measurement of urinary metabolites in sewage streams and the subsequent estimation of consumption rates of the parent compounds have previously been demonstrated for pharmaceuticals and narcotics.
Langford, Katherine H. +3 more
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Confounders of Serum Phosphatidylethanol: Role of Red Blood Cell Turnover and Cirrhosis
Marc Bartel,1,* Vanessa Hofmann,1,* Shijin Wang,2,3 Johannes Mueller,2 Tom R Sundermann,1 Sebastian Mueller2 1Institute of Forensic and Traffic Medicine, Heidelberg University Hospital, Heidelberg, Germany; 2Center for Alcohol Research ...
Bartel M +5 more
doaj
Human‐umbilical‐cord‐mesenchymal‐stem‐cell‐derived exosomes amplify anti‐hepatocellular‐carcinoma effects of gallic acid from Compound Muji Granules. This work identifies absorbed herbal constituents and reveals modulation of IL‐17/MAPK/p53 signaling in HCC organoid models, offering mechanistic insights for exosome‐assisted traditional‐medicine ...
Qiang Zhang +12 more
wiley +1 more source
Ethyl glucuronide (EtG) in hair has emerged as a useful biomarker for detecting alcohol abuse and monitoring abstinence. However, there is a need to establish a reliable cutoff value for the detection of chronic and excessive alcohol ...
Jean Bernard Daeppen +23 more
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This write-up describes the comprehensive facts of tapentadol, on recent trends in synthesis, related substances, analytical methods, pharmacodynamics, pharmacokinetics, adverse effect and drug interaction.
Deepti Jain, Pawan Kumar Basniwal
doaj +1 more source
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer +7 more
wiley +1 more source

