Results 151 to 160 of about 889,444 (319)

Etiology and symptoms of severe hypokalemia in emergency department patients

, 2013
To investigate the prevalence, etiology, and symptoms of severe hypokalemia in patients presenting to the emergency ...
Marti, Grischa, Leichtle, Alexander Benedikt, Lindner, Gregor, Schwarz, Christoph, Arampatzis, Spyridon, Exadaktylos, Aristomenis, Fiedler, Martin   +6 more
core  

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

Consumed by Abdominal Distention

Arthritis Care &Research, EarlyView.
Abimbola Fadairo‐Azinge, James Grenert, Brian Haas, Mary Margaretten   +3 more
wiley   +1 more source

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source

Combined therapy in the treatment of mixed etiology leg ulcer – case report

, 2018
Jarosław Pasek,1 Grzegorz Cieślar,2 Aleksander Sieroń2 1Institute of Physical Education Tourism and Physiotherapy, University of Jan Długosz in Częstochowa, Częstochowa, Poland; 2Department of Internal Medicine, Angiology and Physical Medicine, School ...
Cieślar G, Pasek J, Sieroń A
core  

Crosstalk between acetylation modification and autophagy in cancer: roles, mechanisms, and therapeutic potential

Cell Death Discovery
Acetylation modification and autophagy are fundamental mechanisms regulating cell fate and homeostasis, exhibiting a highly coordinated and dynamic interplay in cancer development.
Yingnan Liu, Ziwei Yan, Zhanqi Fu, Xiaoyang Wu, Fang Wang, Yuan Yuan   +5 more
doaj   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Etiology and Characteristics of Patients Presenting with Eyelid Lacerations at a Level 1 Trauma Center

Abdelhalim A Awidi,1 Jiawei Zhao,2 Ximin Li,1 Fatemeh Rajaii,1 Meleha Ahmad,3 Adrianna Jensen,4 Fasika A Woreta1 1Wilmer Eye Institute, Johns Hopkins Medicine, Baltimore, MD, USA; 2Plastic Surgery Department, The University of Texas MD Anderson Cancer ...
Woreta FA, Li X, Awidi AA, Rajaii F, Ahmad M, Zhao J, Jensen A   +6 more
core  

Mendelian randomization reveals potential causal relationships between cellular senescence-related genes and multiple cancer risks

Communications Biology
Cellular senescence is widely acknowledged as having strong associations with cancer. However, the intricate relationships between cellular senescence-related (CSR) genes and cancer risk remain poorly explored, with insights on causality remaining ...
Xunan Qiu, Rui Guo, Yingying Wang, Shuwen Zheng, Bengang Wang, Yuehua Gong   +5 more
doaj   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source