Results 41 to 50 of about 8,151 (165)

Mutations at beta N265 in γ-aminobutyric acid type A receptors alter both binding affinity and efficacy of potent anesthetics. [PDF]

PLoS ONE, 2014
Etomidate and propofol are potent general anesthetics that act via GABAA receptor allosteric co-agonist sites located at transmembrane β+/α- inter-subunit interfaces.
Deirdre S Stewart, David W Pierce, Mayo Hotta, Alex T Stern, Stuart A Forman   +4 more
doaj   +1 more source

Chinese Society of Pediatric Anesthesiology Guideline for Pediatric Sedation (2025)

Pediatric Anesthesia, Volume 36, Issue 7, Page 850-871, July 2026.
ABSTRACT Background With the increasing variety of pediatric diagnostic procedures, a growing number of children require sedation for diagnostic examinations. Appropriate sedation protocols guarantee the safety of children during sedation and improve its efficiency.
Xingrong Song, Dongxu Lei, Yu Cui, Zhen Du, Yingping Jia, Yue Jin, Hang Tian, Ying Xu, Lifang Yang, Jianmin Zhang, Jijian Zheng, Yunxia Zuo, Liang Zhong, John Zhong, Maryrose Osazuwa, Elizabeth Drum, Charles Dean Kurth, Yue Huang, Qinghua Huang, Heqi Liu, Wei Liu, Rui Ma, Dongpi Wang, Tingting Wang, Zixin Wang, Siwei Wei, Lei Yang, Rui Zhou, Liumei Chen, Weifeng Yu, Jun Li, Mazhong Zhang, Li Zhang, Shuangquan Qu, Shoudong Pan, Rong Wei, Liming Cheng, Yaolong Chen, Xueping Li, Zhenyu Tang   +39 more
wiley   +1 more source

Molecular Mechanisms and Probe‐Dependent Effects of Clinically Relevant GABAA Receptor Modulators

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Combining molecular dynamics, dynamic pharmacophores, and allosteric network analysis, we reveal that benzodiazepines and Z‐drugs stabilize GABA binding through long‐range TMD–ECD allosteric coupling, while anesthetics directly activate the channel via unique L232/I264 contacts, bypassing GABA.
Marvin Taterra, Yuan Chang‐Halabi, Marcel Bermúdez   +2 more
wiley   +1 more source

Magnesium sulfate versus Lidocaine pretreatment for prevention of pain on etomidate injection: A randomized, double-blinded placebo controlled trial

Journal of Research in Pharmacy Practice, 2015
Objective: Etomidate is an imidazole derivative and formulated in 35% propylene glycol. When given without a rapid lidocaine injection, etomidate is associated with pain after injection.
Mohammadreza Safavi, Azim Honarmand, Ashraf Sadat Sahafi, Seyyed Mohammad Sahafi, Mohammadali Attari, Mahsa Payandeh, Alireza Iazdani, Nilofarsaddat Norian   +7 more
doaj   +1 more source

Evaluating Anesthetics for Improving Scientific Research and Welfare Using Larval Zebrafish

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Using physiological and behavioral assays, we quantified the effectiveness and appropriateness of six commonly used fish anesthetics on zebrafish embryos. Different anesthetics performed better under different contexts. Figure prepared using BioRender.com.
Sylvia Dimitriadou, Mhairi Miller, Ali Pilehvar, Lynne U. Sneddon, Jessica L. Bamsey, Damilola Hogan‐Bassey, Maciej Trznadel, Jonathan S. Ball, Aya Takesono, Courtney Hillman, Hannah Rickard, Grace Popplewell, Jenna Corcoran, Tetsuhiro Kudoh, Charles R. Tyler, Matthew J. Winter   +15 more
wiley   +1 more source

Prevention of Etomidate-Induced Myoclonic Movement After Midazolam Co-Induction with Low-Dose Etomidate.

Journal of Health Science and Medical Research (JHSMR), 2011
Objective: To compare the effect of midazolam on the incidence and severity of myoclonic movement from etomidate induction. Materials and Methods: One hundred and tweleve patients, American Society of Anesthesiologists class I-II, were randomly assigned ...
Wirat Wasinwong, Thida n Uakritdathikar, Nalinee Kovitwanawong, Pannipa Pakam   +3 more
doaj  

Sleep magnetoencephalography enhances detection and source imaging of seizures and fast oscillations in focal cortical dysplasia

Epilepsia, Volume 67, Issue 6, Page 2992-3008, June 2026.
Abstract Objective Focal cortical dysplasia (FCD) causes drug‐resistant epilepsy requiring presurgical evaluation. Invasive electroencephalographic (EEG) studies demonstrate that sleep modulates epileptic activity, including interictal epileptiform discharges (IEDs), fast oscillations (FOs) in the beta (14–40 Hz) and gamma (40–80 Hz) frequency bands ...
Marcel Heers, Jawata Afnan, Christoph Braun, Christophe Grova, Dirk‐Matthias Altenmüller, Bernhard J. Steinhoff, Matthias Dümpelmann, Theo Demerath, Horst Urbach, Silke Ethofer, Markus Siegel, Andreas Schulze‐Bonhage, Holger Lerche, Yiwen Li Hegner   +13 more
wiley   +1 more source

Comparing the Effect of Sodium Thiopental, Magnesium Sulfate, Midazolam, Prime Etomidate, and Remifentanil on Myoclonus Incidence and Pain Induced by Anesthesia with Etomidate

مجله دانشکده پزشکی اصفهان, 2018
Background: This study aimed to compare premedication with sodium thiopental, magnesium sulfate, midazolam, prime etomidate dosage, remifentanil, and normal saline on decreasing myoclonus incidence and pain induced by anesthesia with etomidate. Methods:
Mohammadreza Safavi, Azim Honarmand, Shahrbanoo Zolfaghari   +2 more
doaj   +1 more source

The Effect of Remimazolam Administration on Emergence Delirium in Children After General Anesthesia: A Systematic Review With Meta‐Analysis of Randomized Controlled Trials

Pediatric Anesthesia, Volume 36, Issue 6, Page 628-640, June 2026.
ABSTRACT Background Emergence delirium commonly occurs in pediatric patients after general anesthesia, causing distress and potential harm. Remimazolam, an ultra‐short‐acting benzodiazepine, has recently been introduced in pediatric anesthesia, but its preventive role against emergence delirium remains unclear.
Ji‐Na Kim, Hyo‐Seok Na, Hyun‐Jung Shin   +2 more
wiley   +1 more source

Comprehensive Nursing Management of Anticoagulation and Heart Failure Surveillance in a Chinese Patient With Mirror‐Image Dextrocardia Post‐MitraClip Surgery: A First Case Report

Catheterization and Cardiovascular Interventions, Volume 107, Issue 6, Page 1960-1963, May 1, 2026.
ABSTRACT Background Mitral regurgitation (MR) is the valent type of valvular heart disease, caused by primary leaflet lesions or annular dilatation secondary to left ventricular dysfunction. It can lead to a series of complications such as volume overload, exacerbated pulmonary congestion, and heart failure, significantly impacting patient prognosis ...
Juelian Li, Chun Wu, Chao Shang, Yu Deng, Jinxia Zhang   +4 more
wiley   +1 more source