Results 41 to 50 of about 9,607 (202)

To study the effect of three different doses of dexmedetomidine as premedication on the incidence and severity of etomidate-induced myoclonus

The Indian Anaesthetists' Forum, 2023
Background and Aims: Etomidate, a carboxylated imidazole is a rapid-acting nonbarbiturate, nonopioid hypnotic agent that has unique hemodynamic stability, favorable toxic profile, and rapid recovery after a single dose.
Ketki Kaushal, Anita Kumari, Pooja Abbi, Ruchi Gupta   +3 more
doaj   +1 more source

Dexamethasone alleviates etomidate-induced myoclonus by reversing the inhibition of excitatory amino acid transporters

Frontiers in Neuroscience
BackgroundEtomidate can induce myoclonus with an incidence of 50 ~ 85% during anesthesia induction. Dexamethasone, as a long-acting synthetic glucocorticoid, has neuroprotective effects.
Yan Feng, Yan Feng, Min Zhang, Shuai-ying Jia, Yan-xia Guo, Xue Jia, Xue Jia   +6 more
doaj   +1 more source

Electroencephalographic dynamics of etomidate‐induced loss of consciousness

BMC Anesthesiology, 2021
Background Highly structured electroencephalography (EEG) oscillations can occur in adults during etomidate-induced general anesthesia, but the link between these two phenomena is poorly understood.
Lei Zhang, Shunqin Fan, Jiawei Zhang, Kun Fang, Lei Wang, Yuanyuan Cao, Lijian Chen, Xuesheng Liu, Erwei Gu   +8 more
doaj   +1 more source

GABAergic compensation in connexin36 knock-out mice evident during low-magnesium seizure-like event activity

, 2010
Gap junctions within the cerebral cortex may facilitate cortical seizure formation by their ability to synchronize electrical activity. To investigate this, one option is to compare wild-type (WT) animals with those lacking the gene for connexin36 (Cx36 ...
Melin, Sofia M., Jacobson, Gregory M., Voss, Logan J., Sleigh, James W,, Sleigh, James W., Gregory Jacobson, James W. Sleigh, Jacobson, Gregory,, Sofia Melin, Voss, Logan J,, Melin, Sofia,, Logan J. Voss   +11 more
core   +1 more source

Etomidate and Ketamine: Residual Motor and Adrenal Dysfunction that Persist beyond Recovery from Loss of Righting Reflex in Rats

Pharmaceuticals, 2014
We tested the hypothesis that etomidate and ketamine produce residual effects that modify functional mobility (measured by the balance beam test) and adrenal function (adrenocorticotropic hormone (ACTH) stimulation) immediately following recovery from ...
Daniel Diaz-Gil, Noomi Mueller, Ingrid Moreno-Duarte, Hsin Lin, Cenk Ayata, Cristina Cusin, Joseph F. Cotten, Matthias Eikermann   +7 more
doaj   +1 more source

Detection of Etomidate and Etomidate Acid in Urine Using HPLC-MS/MS Method

Fayixue Zazhi
ObjectiveTo establish a high performance liquid chromatography-tandem mass spectrometry （HPLC-MS/MS） method for the detection of etomidate and etomidate acid in urine samples.MethodsProtein in the urine samples was precipitated by adding acetonitrile ...
HE Tian-fu, ZHU Huan-hui, TIAN Yuan-yuan, JIN Yin-shuang, LIN Xian-wen, WANG Song-cai   +5 more
doaj   +1 more source

Butorphanol effectively prevents etomidate-induced myoclonus: a pooled analysis of 788 patients

Journal of International Medical Research, 2019
Objective To evaluate the efficacy of pre-injection of butorphanol on etomidate-induced myoclonus during anesthesia induction. Methods Randomized controlled trials (RCTs) of the ability of butorphanol to prevent etomidate-induced myoclonus were collected
Yu Zhu, Chengmao Zhou, Qixiong He
doaj   +1 more source

Using Etomidate and Midazolam for Screening Colonoscopies Results in More Stable Hemodynamic Responses in Patients of All Ages

Gut and Liver, 2019
Background/Aims Recent studies have demonstrated that etomidate is a safe sedative drug with noninferior sedative effects. In our recent study, we revealed that etomidate/midazolam was more hemodynamically stable than propofol/midazolam in elderly ...
Jung Min Lee, Geeho Min, Bora Keum, Jae Min Lee, Seung Han Kim, Hyuk Soon Choi, Eun Sun Kim, Yeon Seok Seo, Yoon Tae Jeen, Hoon Jai Chun, Hong Sik Lee, Soon Ho Um, Chang Duck Kim   +12 more
doaj   +1 more source

Safer prehospital anaesthesia: updated guidelines from the Association of Anaesthetists

Anaesthesia, EarlyView.
Summary Introduction Prehospital emergency anaesthesia is recognised as a high‐risk clinical intervention. These updated guidelines consider changes in prehospital practice and parallel changes in the practice of in‐hospital emergency anaesthesia, with the aim of encouraging standardised safe anaesthetic practice in a challenging clinical area.
David Lockey, Celestine Weegenaar, Imran Ahmad, Pascale Avery, Philip Cowburn, Richard M. Lyon, Giles Nordmann, Andrew J. Pountney, Cosmo F. M. Scurr, Matthew D. Wiles   +9 more
wiley   +1 more source

Etomidate-Induced myoclonus in Sprague‒Dawley rats involves the activation of neocortical Calpain-2 and its decrement on KCC2 protein

BMC Anesthesiology
Background Etomidate-induced myoclonus has become a pressing clinical problem with an incidence of 50–80%. The underlying mechanism involves neocortical glutamate accumulation and N-methyl-d-aspartate (NMDA) receptor activity.
Yan Feng, Yong-Xiang Cheng, Xing-Hao Wang   +2 more
doaj   +1 more source