Results 21 to 30 of about 8,151 (165)

Etomidate derivatives: Novel pharmaceutical agents in anesthesia

Journal of Anaesthesiology Clinical Pharmacology, 2017
Etomidate is an imidazole derivative that possesses important sedative properties employed in anesthesia practice, however, etomidate has a number of well-know side effects which limit its use in certain subpopulations and over long periods of time ...
Raymond J Malapero, Michael P Zaccagnino, Ethan Y Brovman, Alan David Kaye, Richard D Urman   +4 more
doaj   +1 more source

Dexamethasone alleviates etomidate-induced myoclonus by reversing the inhibition of excitatory amino acid transporters

Frontiers in Neuroscience
BackgroundEtomidate can induce myoclonus with an incidence of 50 ~ 85% during anesthesia induction. Dexamethasone, as a long-acting synthetic glucocorticoid, has neuroprotective effects.
Yan Feng, Yan Feng, Min Zhang, Shuai-ying Jia, Yan-xia Guo, Xue Jia, Xue Jia   +6 more
doaj   +1 more source

To study the effect of three different doses of dexmedetomidine as premedication on the incidence and severity of etomidate-induced myoclonus

The Indian Anaesthetists' Forum, 2023
Background and Aims: Etomidate, a carboxylated imidazole is a rapid-acting nonbarbiturate, nonopioid hypnotic agent that has unique hemodynamic stability, favorable toxic profile, and rapid recovery after a single dose.
Ketki Kaushal, Anita Kumari, Pooja Abbi, Ruchi Gupta   +3 more
doaj   +1 more source

Electroencephalographic dynamics of etomidate‐induced loss of consciousness

BMC Anesthesiology, 2021
Background Highly structured electroencephalography (EEG) oscillations can occur in adults during etomidate-induced general anesthesia, but the link between these two phenomena is poorly understood.
Lei Zhang, Shunqin Fan, Jiawei Zhang, Kun Fang, Lei Wang, Yuanyuan Cao, Lijian Chen, Xuesheng Liu, Erwei Gu   +8 more
doaj   +1 more source

Detection of Etomidate and Etomidate Acid in Urine Using HPLC-MS/MS Method

Fayixue Zazhi
ObjectiveTo establish a high performance liquid chromatography-tandem mass spectrometry （HPLC-MS/MS） method for the detection of etomidate and etomidate acid in urine samples.MethodsProtein in the urine samples was precipitated by adding acetonitrile ...
HE Tian-fu, ZHU Huan-hui, TIAN Yuan-yuan, JIN Yin-shuang, LIN Xian-wen, WANG Song-cai   +5 more
doaj   +1 more source

Butorphanol effectively prevents etomidate-induced myoclonus: a pooled analysis of 788 patients

Journal of International Medical Research, 2019
Objective To evaluate the efficacy of pre-injection of butorphanol on etomidate-induced myoclonus during anesthesia induction. Methods Randomized controlled trials (RCTs) of the ability of butorphanol to prevent etomidate-induced myoclonus were collected
Yu Zhu, Chengmao Zhou, Qixiong He
doaj   +1 more source

Perianesthetic Complications in Genetic Mitochondrial Disease: A Review of Case Reports

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Genetic mitochondrial diseases (GMDs) are a large group of genetically and clinically heterogeneous disorders caused by defects in genes encoding mitochondrial components. GMDs are grouped into named syndromes based on clinical presentation, for example, Leigh syndrome (LS).
Brittany M. Johnson, Simon C. Johnson
wiley   +1 more source

Etomidate-Induced myoclonus in Sprague‒Dawley rats involves the activation of neocortical Calpain-2 and its decrement on KCC2 protein

BMC Anesthesiology
Background Etomidate-induced myoclonus has become a pressing clinical problem with an incidence of 50–80%. The underlying mechanism involves neocortical glutamate accumulation and N-methyl-d-aspartate (NMDA) receptor activity.
Yan Feng, Yong-Xiang Cheng, Xing-Hao Wang   +2 more
doaj   +1 more source

Effects of Esketamine on Emergence Delirium in Children Undergoing Sevoflurane Anesthesia: A Systematic Review, Meta‐Analysis, and Trial Sequential Analysis

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Emergence delirium is a frequent and distressing postoperative complication in children, particularly following sevoflurane‐based anesthesia. Despite its clinical importance, the optimal preventive strategy remains under investigation.
Munder Lateiresh, Abdelaziz Louat, Mukhtar Alwefati, Alhasan Altayf, Matthieu Legrand, Phillip D. Cohen, Eman Abdulwahed, Sapna R. Kudchadkar, Muhammed Elhadi   +8 more
wiley   +1 more source

Etomidate and Ketamine: Residual Motor and Adrenal Dysfunction that Persist beyond Recovery from Loss of Righting Reflex in Rats

Pharmaceuticals, 2014
We tested the hypothesis that etomidate and ketamine produce residual effects that modify functional mobility (measured by the balance beam test) and adrenal function (adrenocorticotropic hormone (ACTH) stimulation) immediately following recovery from ...
Daniel Diaz-Gil, Noomi Mueller, Ingrid Moreno-Duarte, Hsin Lin, Cenk Ayata, Cristina Cusin, Joseph F. Cotten, Matthias Eikermann   +7 more
doaj   +1 more source