Results 131 to 140 of about 11,372 (171)

Host Aging Induces a Senescent-Like Phenotype in Neutrophils and Altered Transcriptional Responses to Streptococcus pneumoniae. [PDF]

Aging Cell
Battaglia MC, Bhalla M, Marzullo B, Betadpur A, Lenhard AP, Mohamed RH, Kalem MC, Heinzinger LR, Leus PA, Labarron S, Garrett-Sinha LA, Mecsas J, Blumental-Perry A, Bou Ghanem EN.   +13 more
europepmc   +1 more source

EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes [PDF]

Oncogene, 2000
ETS1 is a member of the evolutionarily conserved family of ets genes, which are transcription factors that bind to unique DNA sequences, either alone or by association with other proteins. In this study, we have used the yeast two-hybrid system to identify an ETS1 interacting protein.
Dennis Watson, Runzhao Li, Watson Dennis K   +2 more
exaly   +3 more sources

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The role of the transcription factor Ets1 in carcinoma

Seminars in Cancer Biology, 2015
Ets1 belongs to the large family of the ETS domain family of transcription factors and is involved in cancer progression. In most carcinomas, Ets1 expression is linked to poor survival. In breast cancer, Ets1 is primarily expressed in the triple-negative subtype, which is associated with unfavorable prognosis.
Jürgen Dittmer
exaly   +3 more sources

Review of Ets1 structure, function, and roles in immunity [PDF]

Cellular and Molecular Life Sciences, 2013
The Ets1 transcription factor is a member of the Ets gene family and is highly conserved throughout evolution. Ets1 is known to regulate a number of important biological processes in normal cells and in tumors. In particular, Ets1 has been associated with regulation of immune cell function and with an aggressive behavior in tumors that express it at ...
Lee Ann Garrett-Sinha, Garrett-Sinha Lee Ann   +1 more
exaly   +3 more sources

The Ets1 proto-oncogene is upregulated by retinoic acid: characterization of a functional retinoic acid response element in the Ets1 promoter [PDF]

Oncogene, 2000
The v-ets oncoprotein and its progenitor Ets1 belong to a family of transcription factors that are related by an 85 amino acid conserved DNA binding domain, the ets domain. Ets1 plays important role(s) in control of cell proliferation, differentiation and apoptosis.
Arun Seth, Dennis Watson, Ismail Kola
exaly   +3 more sources

Splicing variant ΔVII-Ets1 is downregulated in invasive Ets1-expressing breast cancer cells

International Journal of Oncology, 2003
Transcription factor Ets1 is expressed in invasive breast cancer cells. In T-cells, the splicing variant DeltaVII-Ets1 is naturally produced along with full length Ets1 (fl-Ets1). Though its function is unknown, the lack of important inhibitory domains predicts a regulatory role of DeltaVII-Ets1 in fl-Ets1-controlled transcription.
Pia, Ballschmieter, Melanie, Braig, Ralph K, Lindemann, Alfred, Nordheim, Jürgen, Dittmer   +4 more
openaire   +2 more sources

An update on the roles of transcription factor Ets1 in autoimmune diseases

WIREs Mechanisms of Disease, 2023
AbstractTranscription factors are crucial to regulate gene expression in immune cells and in other cell types. In lymphocytes, there are a large number of different transcription factors that are known to contribute to cell differentiation and the balance between quiescence and activation. One such transcription factor is E26 oncogene homolog 1 (Ets1).
Lee Ann Garrett-Sinha
exaly   +3 more sources

ETS1-DNA Binding and Intercalation: Correction

Science, 1997
In the article "Intercalation, DNA kinking, and the control of transcription ([9 Feb. 1996, p. 778][1]), we reviewed the hypothesis that minor groove intercalation and DNA kinking represented an important mechanism for the control of transcription ([1][2]).
M H, Werner, A M, Gronenborn, G M, Clore
openaire   +2 more sources

SP100 inhibits ETS1 activity in primary endothelial cells [PDF]

Oncogene, 2004
SP100 was first identified as a nuclear autoimmune antigen and is a constituent of the nuclear body. SP100 interacts with the ETS1 transcription factor, and we have previously shown that SP100 reduces ETS1-DNA binding and inhibits ETS1 transcriptional activity on the MMP1 and uPA promoters.
Damien Chaussabel, Dennis Watson, Runzhao Li   +2 more
exaly   +3 more sources

GATA4 Regulates Developing Endocardium Through Interaction With ETS1

Circulation Research, 2022
Background: The pioneer transcription factor (TF) GATA4 (GATA Binding Protein 4) is expressed in multiple cardiovascular lineages and is essential for heart development. GATA4 lineage-specific occupancy in the developing heart underlies its lineage specific activities.
Pingzhu Zhou, Yan Zhang, Isha Sethi, Lincai Ye, Michael A. Trembley, Yangpo Cao, Brynn N. Akerberg, Feng Xiao, Xiaoran Zhang, Kai Li, Blake D. Jardin, Neil Mazumdar, Qing Ma, Aibin He, Bin Zhou, William T. Pu   +15 more
openaire   +2 more sources