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EAPII interacts with ETS1 and modulates its transcriptional function [PDF]

Oncogene, 2003
Ets proteins constitute a family of conserved sequence-specific DNA-binding proteins and function as transcription factors. ETS1 plays important roles in differentiation, lymphoid cell development, invasiveness and angiogenesis. Such diverse roles of ETS1 are likely to be dependent on its associated proteins. A yeast two-hybrid screen was conducted and
Dennis Watson, Qixin Leng, Runzhao Li
exaly   +3 more sources

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CHARACTERIZATION OF ECTOPICALLY-EXPRESSED ETS1 IN HUMAN COLON-CANCER CELLS - INDUCTION OF PUTATIVE ETS1-TARGET GENE

International Journal of Oncology, 1993
We have previously shown that the ETS1 gene is expressed in a tissue-specific manner, and encodes a transcription factor, that may be involved in lymphocyte development, activation and proliferation. To understand the ETS1 function in non-lymphoid cells, we have ectopically expressed ETS1 protein in a human colon cancer cell line, and studied its ...
H, Suzuki, V, Romanospica, P, Georgiou, R, Fisher, T, Papas, N, Bhat   +5 more
openaire   +2 more sources

Functional redundancy of Ets1 and Ets2

Blood, 2009
In this issue of Blood, Wei and colleagues investigate the overlapping roles of Ets1 and Ets2 in the regulation of endothelial cell function and survival during embryonic angiogenesis ...
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Epitope Mapping of Human ETS1 Monoclonal Antibody

Hybridoma, 1994
The epitope for E44 monoclonal antibody (mAb) was mapped using mutated ETS1 proteins lacking different carboxy-terminal regions and by the employment of synthetic oligopeptides spanning the epitope region. This epitope lies around Arg211 of the human ETS1 protein since substitution of Arg211 by Gln211 in the epitope region results in the loss of ...
N K, Bhat, V, Romano-Spica, P, Georgiou, S L, Chen, P G, Kui, H, Suzuki   +5 more
openaire   +2 more sources

Correction of the NMR structure of the ETS1/DNA complex

Journal of Biomolecular NMR, 1997
The ETS family of transcription factors consists of a group of proteins that share a highly conserved 85 amino acid DNA-binding domain (DBD). This family recognizes a consensus sequence rich in purine bases with a central GGAA motif. A comparison of the published three-dimensional structures of the DBD/DNA complexes of ETS1 by NMR [Werner et al. (1995)
M H, Werner, G M, Clore, C L, Fisher, R J, Fisher, L, Trinh, J, Shiloach, A M, Gronenborn   +6 more
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INFLUENCE OF NUCLEOTIDES FLANKING THE GGAA CORE SEQUENCE ON ETS1 AND ETS2 DNA-BINDING ACTIVITY AND THE MECHANISM OF ETS1 AUTOREGULATION

International Journal of Oncology, 1992
The Ets family of genes encode nuclear proteins that activate transcription by binding to a specific purine-rich (GGAA) ets binding sequence (EBS) present in promoters/enhancers of various genes. We have previously shown that over-expression of ets1 via transfection of ets1 expression vectors into NIH3T3 cells induced the expression of the endogenous ...
R, Ascione, D, Thompson, R, Thomas, A, Panayiotakis, R, Ramsay, M, Tymms, I, Kola, A, Seth   +7 more
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Expression of c-Ets1 Protein in Normal Human Placenta

Gynecologic and Obstetric Investigation, 2006
<i>Background:</i> The proto-oncogene product c-Ets1 is a transcriptional factor that controls the expression of a number of genes involved in extracellular matrix remodeling such as stromelysin-1 (matrix metalloproteinase-3; MMP-3), collagenase-1, and urokinase-type plasminogen activator (u-PA).
Noriyuki, Takai, Tami, Ueda, Hisashi, Narahara, Isao, Miyakawa   +3 more
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c-Ets1 is a promising marker in epithelial ovarian cancer

International Journal of Molecular Medicine, 2002
c-Ets1 controls the expression of some genes involved in extracellular matrix remodeling. To elucidate the involvement of c-Ets1 in epithelial ovarian carcinogenesis, we investigated the role of the proto-oncogene c-ets1 in the regulation of physiological processes such as cell proliferation, differentiation, and tumor invasion.
N, Takai, T, Miyazaki, M, Nishida, K, Nasu, I, Miyakawa   +4 more
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Importance of Ets1 Proto-Oncogene for Breast Cancer Progression

Zentralblatt für Gynäkologie, 2004
Ets proteins are transcription factors, which share a unique DNA binding domain, the Ets domain. Some members of the Ets family are implicated in tumorigenesis. Ets1, the founder of the Ets family, is predominantly expressed in invasive tumors and able to activate certain genes encoding ECM-degrading proteases.
J, Dittmer, M, Vetter, S G, Blumenthal, R K, Lindemann, H, Kölbl   +4 more
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Role of ETS1 in IL-2 gene expression.

The Journal of Immunology, 1995
Abstract The ETS1 gene encodes a sequence-specific transcription factor binding to purine-rich DNA sequences (-GGAA-) present in the transcriptional regulatory regions of many cellular and viral promoters/enhancers, including many lymphokine genes.
V, Romano-Spica, P, Georgiou, H, Suzuki, T S, Papas, N K, Bhat   +4 more
openaire   +2 more sources