Positive Feedback Between PU.1 and the Cell Cycle Controls Myeloid Differentiation [PDF]
, 2013 Regulatory gene circuits with positive-feedback loops control stem cell differentiation, but several mechanisms can contribute to positive feedback. Here, we dissect feedback mechanisms through which the transcription factor PU.1 controls lymphoid and ...
Champhekhar, Ameya +4 more
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The promoter regions of intellectual disability-associated genes are uniquely enriched in LTR sequences of the MEr41 primate-specific endogenous retrovirus: An evolutionary connection between immunity and cognition [PDF]
, 2019 The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fgene.2019.00321/full#supplementary-materialSocial behavior and neuronal connectivity in rodents have been shown to be shaped by the ...
Benítez Burraco, Antonio +2 more
core +6 more sources
MedCommCellular senescence is a significant contributor to various age‐related diseases. Tet methylcytosine dioxygenase 3 (TET3) is a pivotal regulator of epigenetic modifications, and this study aimed to elucidate its role in cellular senescence.
Yanqi Dang +7 more
doaj +1 more source
A Concise Atlas of Thyroid Cancer Next-Generation Sequencing Panel ThyroSeq v.2 [PDF]
, 2017 The next-generation sequencing technology allows high out-put genomic analysis. An innovative assay in thyroid cancer, ThyroSeq® was developed for targeted mutation detection by next generation sequencing technology in fine needle aspiration and tissue ...
Alsina, Jorge, Alsina, Raul, Gulec, Seza
core +2 more sources
Salsalate improves the anti-tumor efficacy of lenvatinib in MASH-driven hepatocellular carcinoma
JHEP ReportsBackground & Aims: Metabolic dysfunction-associated steatohepatitis (MASH) is a growing cause of hepatocellular carcinoma (HCC) worldwide. The complex microenvironment of these tumors, characterized by metabolic dysfunction, hypoxia, steatosis, and ...
Evangelia E. Tsakiridis +14 more
doaj +1 more source
GSAE: an autoencoder with embedded gene-set nodes for genomics functional characterization
, 2018 Bioinformatics tools have been developed to interpret gene expression data at the gene set level, and these gene set based analyses improve the biologists' capability to discover functional relevance of their experiment design. While elucidating gene set
Chen, Hung-I Harry +5 more
core +3 more sources
Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation [PDF]
, 1993 The gene encoding the receptor for macrophage colony-stimulating factor 1 (CSF-1), the c-fms protooncogene, is selectively expressed in immature and mature mononuclear phagocytes and trophoblasts. Exon 1 is expressed only in trophoblasts.
Yue, Xie +4 more
core +1 more source
Somatic chromosomal translocation between Ewsr1 and Fli1 loci leads to dilated cardiomyopathy in a mouse model [PDF]
, 2015 A mouse model that recapitulates the human Ewing's sarcoma-specific chromosomal translocation was generated utilizing the Cre/loxP-mediated recombination technique.
Jay, Patrick Y +8 more
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Pebp2/cbf, the Murine Homolog of the Human Myeloid Aml1 and Pebp2-Beta/cbf-Beta Proto-Oncoproteins, Regulates the Murine Myeloperoxidase and Neutrophil Elastase Genes in Immature Myeloid Cells [PDF]
, 1994 The myeloperoxidase (MPO) and neutrophil elastase genes are expressed specifically in immature myeloid cells. The integrity of a polyomavirus enhancer core sequence, 5'-AACCACA-3', is critical to the activity of the murine MPO proximal enhancer.
Nuchprayoon, I. +5 more
core +2 more sources
, 2014 Central role of astrocyte elevated gene-1 (AEG-1) in regulating diverse aspects of hepatocellular carcinoma (HCC) pathogenesis and association of its overexpression with HCC progression has been demonstrated.
Gholipour, N. +2 more
core +1 more source