Results 1 to 10 of about 11,372 (171)

Enhanced ETS1 stability by DNAPKcs orchestrates transcriptional changes during chemoresistance in triple negative breast cancer [PDF]

npj Breast Cancer
Triple Negative Breast Cancer (TNBC) accounts for ~20% of all breast cancers and results in thousands of deaths every year. The median survival of TNBC patients sharply declines with the development of chemoresistance and metastatic disease.
Aiindrila Dhara, Imlimaong Aier, Souhadri Das, Manash Sarkar, Ramandeep Kaur, Pritish Kumar Varadwaj, Samrat Daripa, Sumit Kumar Hira, Anindya Halder, Nirmalya Sen   +9 more
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CA9-Targeted Liposomal Delivery of siETS1 Inhibits Clear Cell Renal Cell Carcinoma Progression by Disrupting the ETS1/MYC Regulatory Axis [PDF]

International Journal of Nanomedicine
Yuyang Ye,1 Jing Sun,2 Yizheng Zhang,1 Shenghan Wang,3 Zhaoqian Meng4 1Department of Anesthesiology, The Second Qilu Hospital of ShanDong University, ShanDong University, Jinan, 250033, People’s Republic of China; 2Cheeloo College of Medicine, Shandong ...
Ye Y, Sun J, Zhang Y, Wang S, Meng Z
doaj   +2 more sources

Ets1-Mediated Acetylation of FoxO1 Is Critical for Gluconeogenesis Regulation during Feed-Fast Cycles

Cell Reports, 2019
Summary: The homeostatic balance of hepatic glucose uptake and production is exquisitely controlled by hormonal signals during feed-fast cycles.
Fang Chen, Xiao Han, Peng Sun
exaly   +3 more sources

Single-cell identifies and validates human circulating Treg subtype/state Treg fci in non-small cell lung cancer [PDF]

Signal Transduction and Targeted Therapy
Regulatory T cells (Treg) play immunosuppressive roles in lung cancer and are key biomarkers in cancer immunology. Using scRNA-seq and stereo-seq, we aimed to identify a novel circulating Treg subtype in non-small cell lung cancer (NSCLC). We developed a
Xuanqi Liu, Yifei Liu, Wanxin Duan, Jianming Weng, Hao Dai, Fangming Liu, Lingyan Wang, Mengjia Qian, Bijun Zhu, Shuyao Wu, Youqiong Ye, Muhan Yuan, Shaojun Hong, Mingjie Wang, Yunfeng Cheng, Tianxiang Chen, Duojiao Wu, Yuanlin Song, Xiangdong Wang   +18 more
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Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science
Clear cell renal cell carcinoma (ccRCC) is a common and aggressive form of kidney cancer with VHL mutations present in > 50% of cases. These mutations lead to dysregulation of hypoxia‐inducible factors (HIFs) and activation of oncogenic pathways, making ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
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A prognostic risk prediction model for gastric cancer based on the EFNA4 and ETS1 regulatory axis in tumor cells [PDF]

Scientific Reports
Gastric cancer (GC) is a major cause of cancer-related deaths worldwide, and is characterised by intricate molecular mechanisms. However, analysis of its molecular and clinical characteristics is complicated by its histological and etiological ...
Yixuan Chen, Ning Wang, Junkun Wang, Shupei Li, Wenchen Zhang, Wenjiang Deng, Jingjing Ye, Zhoujuan Yao, Hui Zhang, Fengsong Wang, Wenbin Wang   +10 more
doaj   +2 more sources

Implication of p16 Promoter Methylation, the BRAFV600E Mutation, and ETS1 Expression Determination on Papillary Thyroid Carcinoma Prognosis and High-Risk Patients’ Selection [PDF]

Biomedicines
Background/Objectives: Papillary thyroid carcinoma (PTC) is the most common malignancy of the endocrine system, characterized by various molecular alterations.
Stefana Stojanović Novković, Sonja Šelemetjev, Milena Krajnović, Ana Božović, Bojana Kožik, Uršula Prosenc Zmrzljak, Tijana Išić Denčić   +6 more
doaj   +2 more sources

Phosphorylation-mediated interaction between human E26 transcription factor 1 and specific protein 1 is required for tumor cell migration

Acta Biochimica et Biophysica Sinica, 2022
Transcription factors, human E26 transcription factor 1 (Ets1) and specific protein 1 (Sp1), are known to induce gene expression in tumorigenicity. High Ets1 expression is often associated with colorectal tumorigenesis.
Wen Xianhui, Sun Xingsheng, Ou Zheyuan, Jiang Jun, Chen Qingmei, He Xirong, Hu Zhangsheng, Qiao Han, Zhou Kuan, Li Xin, Deng Yiqun, Wen Jikai   +11 more
doaj   +1 more source

Transcription factor Ets1 regulates expression of thioredoxin-interacting protein and inhibits insulin secretion in pancreatic β-cells. [PDF]

PLoS ONE, 2014
Long-term activation of extracellular-regulated kinase (ERK1/2) pathway has been shown to cause glucotoxicity and inhibit insulin gene expression in β-cells.
Yan Luo, Fengli He, Li Hu, Luo Hai, Meifeng Huang, Zhipeng Xu, Jingjing Zhang, Zhiguang Zhou, Feng Liu, Yan-Shan Dai   +9 more
doaj   +1 more source

Ets1 induces dysplastic changes when expressed in terminally-differentiating squamous epidermal cells. [PDF]

PLoS ONE, 2009
BACKGROUND: Ets1 is an oncogene that functions as a transcription factor and regulates the activity of many genes potentially important for tumor initiation and progression.
Priyadharsini Nagarajan, Neha Parikh, Lee Ann Garrett-Sinha, Satrajit Sinha   +3 more
doaj   +1 more source