The Biology of the Ets1 Proto-Oncogene [PDF]
Molecular Cancer, 2003 The Ets1 proto-oncoprotein is a member of the Ets family of transcription factors that share a unique DNA binding domain, the Ets domain. The DNA binding activity of Ets1 is controlled by kinases and transcription factors.
Jürgen Dittmer
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Enhanced ETS1 stability by DNAPKcs orchestrates transcriptional changes during chemoresistance in triple negative breast cancer [PDF]
npj Breast CancerTriple Negative Breast Cancer (TNBC) accounts for ~20% of all breast cancers and results in thousands of deaths every year. The median survival of TNBC patients sharply declines with the development of chemoresistance and metastatic disease.
Aiindrila Dhara +9 more
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ETS1–EGR2 facilitates renal cell carcinoma progression by activating NOTCH signalling [PDF]
Clinical and Translational MedicineBackground Renal cell carcinoma (RCC) is known as one of the three major malignant tumors of the urinary system, and clear‐cell RCC (ccRCC) is the most frequent and aggressive pathological subtype and is correlated with high mortality.
Weifeng Ye +6 more
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Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation [PDF]
Advanced ScienceClear cell renal cell carcinoma (ccRCC) is a common and aggressive form of kidney cancer with VHL mutations present in > 50% of cases. These mutations lead to dysregulation of hypoxia‐inducible factors (HIFs) and activation of oncogenic pathways, making ...
Taowei Yang +15 more
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CA9-Targeted Liposomal Delivery of siETS1 Inhibits Clear Cell Renal Cell Carcinoma Progression by Disrupting the ETS1/MYC Regulatory Axis [PDF]
International Journal of NanomedicineYuyang Ye,1 Jing Sun,2 Yizheng Zhang,1 Shenghan Wang,3 Zhaoqian Meng4 1Department of Anesthesiology, The Second Qilu Hospital of ShanDong University, ShanDong University, Jinan, 250033, People’s Republic of China; 2Cheeloo College of Medicine, Shandong ...
Ye Y, Sun J, Zhang Y, Wang S, Meng Z
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Cell Reports, 2019 Summary: The homeostatic balance of hepatic glucose uptake and production is exquisitely controlled by hormonal signals during feed-fast cycles.
Fang Chen, Xiao Han, Peng Sun
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Single-cell identifies and validates human circulating Treg subtype/state Treg fci in non-small cell lung cancer [PDF]
Signal Transduction and Targeted TherapyRegulatory T cells (Treg) play immunosuppressive roles in lung cancer and are key biomarkers in cancer immunology. Using scRNA-seq and stereo-seq, we aimed to identify a novel circulating Treg subtype in non-small cell lung cancer (NSCLC). We developed a
Xuanqi Liu +18 more
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ETS1 suppresses hepatic stellate cell activation and liver fibrosis [PDF]
JCI InsightChronic liver injury results in activation of quiescent hepatic stellate cells (HSCs) into collagen type I–producing activated HSCs that make the liver fibrotic.
Wonseok Lee +9 more
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A prognostic risk prediction model for gastric cancer based on the EFNA4 and ETS1 regulatory axis in tumor cells [PDF]
Scientific ReportsGastric cancer (GC) is a major cause of cancer-related deaths worldwide, and is characterised by intricate molecular mechanisms. However, analysis of its molecular and clinical characteristics is complicated by its histological and etiological ...
Yixuan Chen +10 more
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Acta Biochimica et Biophysica Sinica, 2022 Transcription factors, human E26 transcription factor 1 (Ets1) and specific protein 1 (Sp1), are known to induce gene expression in tumorigenicity. High Ets1 expression is often associated with colorectal tumorigenesis.
Wen Xianhui +11 more
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