Results 1 to 10 of about 13,206 (170)

Enhanced ETS1 stability by DNAPKcs orchestrates transcriptional changes during chemoresistance in triple negative breast cancer [PDF]

npj Breast Cancer
Triple Negative Breast Cancer (TNBC) accounts for ~20% of all breast cancers and results in thousands of deaths every year. The median survival of TNBC patients sharply declines with the development of chemoresistance and metastatic disease.
Aiindrila Dhara, Imlimaong Aier, Souhadri Das, Manash Sarkar, Ramandeep Kaur, Pritish Kumar Varadwaj, Samrat Daripa, Sumit Kumar Hira, Anindya Halder, Nirmalya Sen   +9 more
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ETS1–EGR2 facilitates renal cell carcinoma progression by activating NOTCH signalling [PDF]

Clinical and Translational Medicine
Background Renal cell carcinoma (RCC) is known as one of the three major malignant tumors of the urinary system, and clear‐cell RCC (ccRCC) is the most frequent and aggressive pathological subtype and is correlated with high mortality.
Weifeng Ye, Sishun Gan, Qiang Xu, Xiaoyang Shu, Panpan Dong, Lin Li, Chao Tang   +6 more
doaj   +2 more sources

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation [PDF]

Advanced Science
Clear cell renal cell carcinoma (ccRCC) is a common and aggressive form of kidney cancer with VHL mutations present in > 50% of cases. These mutations lead to dysregulation of hypoxia‐inducible factors (HIFs) and activation of oncogenic pathways, making ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
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CA9-Targeted Liposomal Delivery of siETS1 Inhibits Clear Cell Renal Cell Carcinoma Progression by Disrupting the ETS1/MYC Regulatory Axis [PDF]

International Journal of Nanomedicine
Yuyang Ye,1 Jing Sun,2 Yizheng Zhang,1 Shenghan Wang,3 Zhaoqian Meng4 1Department of Anesthesiology, The Second Qilu Hospital of ShanDong University, ShanDong University, Jinan, 250033, People’s Republic of China; 2Cheeloo College of Medicine, Shandong ...
Ye Y, Sun J, Zhang Y, Wang S, Meng Z
doaj   +2 more sources

Single-cell identifies and validates human circulating Treg subtype/state Treg fci in non-small cell lung cancer [PDF]

Signal Transduction and Targeted Therapy
Regulatory T cells (Treg) play immunosuppressive roles in lung cancer and are key biomarkers in cancer immunology. Using scRNA-seq and stereo-seq, we aimed to identify a novel circulating Treg subtype in non-small cell lung cancer (NSCLC). We developed a
Xuanqi Liu, Yifei Liu, Wanxin Duan, Jianming Weng, Hao Dai, Fangming Liu, Lingyan Wang, Mengjia Qian, Bijun Zhu, Shuyao Wu, Youqiong Ye, Muhan Yuan, Shaojun Hong, Mingjie Wang, Yunfeng Cheng, Tianxiang Chen, Duojiao Wu, Yuanlin Song, Xiangdong Wang   +18 more
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ETS1 suppresses hepatic stellate cell activation and liver fibrosis [PDF]

JCI Insight
Chronic liver injury results in activation of quiescent hepatic stellate cells (HSCs) into collagen type I–producing activated HSCs that make the liver fibrotic.
Wonseok Lee, Xiao Liu, Sara Brin Rosenthal, Charlene Miciano, Sadatsugu Sakane, Kanani Hokutan, Debanjan Dhar, Hyun Young Kim, David A. Brenner, Tatiana Kisseleva   +9 more
doaj   +2 more sources

A prognostic risk prediction model for gastric cancer based on the EFNA4 and ETS1 regulatory axis in tumor cells [PDF]

Scientific Reports
Gastric cancer (GC) is a major cause of cancer-related deaths worldwide, and is characterised by intricate molecular mechanisms. However, analysis of its molecular and clinical characteristics is complicated by its histological and etiological ...
Yixuan Chen, Ning Wang, Junkun Wang, Shupei Li, Wenchen Zhang, Wenjiang Deng, Jingjing Ye, Zhoujuan Yao, Hui Zhang, Fengsong Wang, Wenbin Wang   +10 more
doaj   +2 more sources

Phosphorylation-mediated interaction between human E26 transcription factor 1 and specific protein 1 is required for tumor cell migration

Acta Biochimica et Biophysica Sinica, 2022
Transcription factors, human E26 transcription factor 1 (Ets1) and specific protein 1 (Sp1), are known to induce gene expression in tumorigenicity. High Ets1 expression is often associated with colorectal tumorigenesis.
Wen Xianhui, Sun Xingsheng, Ou Zheyuan, Jiang Jun, Chen Qingmei, He Xirong, Hu Zhangsheng, Qiao Han, Zhou Kuan, Li Xin, Deng Yiqun, Wen Jikai   +11 more
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Transcription factor Ets1 regulates expression of thioredoxin-interacting protein and inhibits insulin secretion in pancreatic β-cells. [PDF]

PLoS ONE, 2014
Long-term activation of extracellular-regulated kinase (ERK1/2) pathway has been shown to cause glucotoxicity and inhibit insulin gene expression in β-cells.
Yan Luo, Fengli He, Li Hu, Luo Hai, Meifeng Huang, Zhipeng Xu, Jingjing Zhang, Zhiguang Zhou, Feng Liu, Yan-Shan Dai   +9 more
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Regulation of MMP9 transcription by ETS1 in immortalized salivary gland epithelial cells of patients with salivary hypofunction and primary Sjögren’s syndrome

Scientific Reports, 2022
Primary Sjögren’s syndrome (pSS) patients exhibit enhanced degradation of the salivary epithelium initially through MMP9 overexpression. We assessed the expression of MMP9 and an associated transcription factor, ETS1, in primary salivary gland epithelial
Braxton Noll, Farah Bahrani Mougeot, Michael T. Brennan, Jean-Luc C. Mougeot   +3 more
doaj   +1 more source