Results 41 to 50 of about 13,206 (170)
, 2019 Mutations in and reduced expression of the ETS1 gene may be associated with systemic lupus erythematosus (SLE). Here, we report a replication study to investigate associations of eight ETS1 single-nucleotide polymorphisms in the 3′-untranslated region (3′
Bangpin Pan (6855194) +3 more
core +1 more source
Genome-wide identification of target genes for the key B cell transcription factor Ets1 [PDF]
, 2017 BACKGROUND: The transcription factor Ets1 is highly expressed in B lymphocytes. Loss of Ets1 leads to premature B cell differentiation into antibody-secreting cells (ASCs), secretion of autoantibodies, and development of autoimmune disease.
Kearly, A +3 more
core +1 more source
RUNX1‐Driven CPXM1 Transcription Promotes Malignant Phenotypes and EMT in Gastric Cancer Cells
Cancer Science, EarlyView.RUNX1 transcriptionally activates CPXM1, promotes EMT, and enhances the proliferation, invasion, and metastasis of gastric cancer cells. ABSTRACT Gastric cancer (GC) remains a leading cause of cancer‐related mortality worldwide, with current treatment strategies largely limited to surgery, chemotherapy, and targeted therapy.
Ping Jia +8 more
wiley +1 more source
NF-κB/p52 augments ETS1 binding genome-wide to promote glioma progression
Communications Biology, 2023 Gliomas are highly invasive and chemoresistant cancers, making them challenging to treat. Chronic inflammation is a key driver of glioma progression as it promotes aberrant activation of inflammatory pathways such as NF-κB signalling, which drives cancer
Nicholas Sim, Yinghui Li
doaj +1 more source
Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling
Cytopathology, EarlyView.Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu +3 more
wiley +1 more source
Comparisons of mDCC maps between the (Ets1)2–DNA and single Ets1–DNA models.
, 2014 The upper triangle shows mDCC values in the single Ets1–DNA model, with the color gradation from blue to red corresponding to mDCC values from −1.0 to 1.0. The lower triangle shows differences of the mDCC values in the single Ets1–DNA model from those in
Ikuo Fukuda (467002) +2 more
core +1 more source
microRNA-9 suppresses the proliferation, invasion and metastasis of gastric cancer cells through targeting cyclin D1 and Ets1. [PDF]
PLoS ONE, 2013 Recent evidence shows that altered microRNA-9 (miR-9) expression is implicated in the progression of gastric cancer. However, the exact roles and underlying mechanisms of miR-9 in the proliferation, invasion and metastasis of gastric cancer still remain ...
Liduan Zheng +7 more
doaj +1 more source
Oral Diseases, EarlyView.ABSTRACT Objectives To identify molecular mechanisms distinguishing the erosive subtype of oral lichen planus (EOLP) from the non‐erosive subtype (NEOLP) through transcriptomic analysis. Methods We analysed bulk RNA‐seq data from 30 buccal mucosa samples (13 EOLP, 17 NEOLP) using differential expression, Gene Set Enrichment Analysis (GSEA ...
Kisung Sheen +5 more
wiley +1 more source
Comparison of intermolecular hydrogen bonds in (Ets1)2•2DNA and (Ets1)2•DNA complexes.
, 2013 (A) Intermolecular hydrogen bonds between Ets1 and the neighboring DNA duplex within (Ets1)2•2DNA complex. (B) Intermolecular hydrogen bonds between Ets1 subunits in (Ets1)2•DNA complex.
Nigar D. Babayeva (329636) +2 more
core +1 more source
Molecular Medicine, 2021 Background Diabetic nephropathy (DN) is currently the leading cause of end-stage renal disease globally. The endothelial-to-mesenchymal transition (EndMT) of glomerular endothelial cells has been reported to play a crucial role in DN.
Lihong Lu +5 more
doaj +1 more source