Results 41 to 50 of about 13,453 (162)
Role of SoxE transcription factors in development and disease
Developmental Dynamics, EarlyView.Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley +1 more source
microRNA-9 suppresses the proliferation, invasion and metastasis of gastric cancer cells through targeting cyclin D1 and Ets1. [PDF]
PLoS ONE, 2013 Recent evidence shows that altered microRNA-9 (miR-9) expression is implicated in the progression of gastric cancer. However, the exact roles and underlying mechanisms of miR-9 in the proliferation, invasion and metastasis of gastric cancer still remain ...
Liduan Zheng +7 more
doaj +1 more source
Cellular diversity of the developing chick trigeminal ganglion at single‐cell resolution
Developmental Dynamics, EarlyView.Abstract Background The trigeminal ganglion (TG) integrates sensory input from the face and jaw and is derived from two embryonic cell populations: neural crest and cranial placode. These populations interact during TG development to coordinate specification, differentiation, and organization, but the molecular characteristics of the heterogeneous cell
Arvind Arul Nambi Rajan +1 more
wiley +1 more source
ETS1 knockdown counteracts high-glucose induced reduction of VPC numbers.
, 2013 Mononuclear cells were transfected with ETS1-specific siRNA (ets1), a scrambled control (scr) at day 0 or left untransfected and stimulated with glucose. After 3 days of culture, VPC were stained and counted by independent investigators (left side). Data
Judith Haendeler (264054) +5 more
core +1 more source
NF-κB/p52 augments ETS1 binding genome-wide to promote glioma progression
Communications Biology, 2023 Gliomas are highly invasive and chemoresistant cancers, making them challenging to treat. Chronic inflammation is a key driver of glioma progression as it promotes aberrant activation of inflammatory pathways such as NF-κB signalling, which drives cancer
Nicholas Sim, Yinghui Li
doaj +1 more source
Phytotherapy Research, EarlyView.Hyperoside ameliorates metabolic dysfunction in high‐fat diet‐induced type 2 diabetic mice, accompanied by enhanced brown adipose tissue thermogenic activity, inguinal white adipose tissue browning‐related changes, reduced M1 macrophage polarization, and gut microbiota remodeling.
WeiFeng Cai +7 more
wiley +1 more source
Molecular Medicine, 2021 Background Diabetic nephropathy (DN) is currently the leading cause of end-stage renal disease globally. The endothelial-to-mesenchymal transition (EndMT) of glomerular endothelial cells has been reported to play a crucial role in DN.
Lihong Lu +5 more
doaj +1 more source
RUNX1‐Driven CPXM1 Transcription Promotes Malignant Phenotypes and EMT in Gastric Cancer Cells
Cancer Science, EarlyView.RUNX1 transcriptionally activates CPXM1, promotes EMT, and enhances the proliferation, invasion, and metastasis of gastric cancer cells. ABSTRACT Gastric cancer (GC) remains a leading cause of cancer‐related mortality worldwide, with current treatment strategies largely limited to surgery, chemotherapy, and targeted therapy.
Ping Jia +8 more
wiley +1 more source
Identification and analysis of global ETS1 target genes.
, 2019 Sankey plot showing target genes of ETS1 based on the integration of RNA-Seq and ChIP-Seq data-sets. The tails of the plot display selected ETS1-dependent pathways revealed by gene-set enrichment analysis.
Maria Tsompana (3037167) +6 more
core +1 more source
Interaction of human T-cell lymphotropic virus type I Tax, Ets1, and Sp1 in transactivation of the PTHrP P2 promoter. [PDF]
, 1997 We have previously shown that the parathyroid hormone-related protein (PTHrP) promoter contains binding sites for transcription factors Ets1 and Sp1 and that human T-cell lymphotropic virus type I (HTLV-I) Tax cooperates with Ets1 to transactivate the ...
Dittmer, J +4 more
core +1 more source