Results 31 to 40 of about 11,372 (171)

REST promotes ETS1‐dependent vascular growth in medulloblastoma [PDF]

Molecular Oncology, 2021
Expression of the RE1‐silencing transcription factor (REST), a master regulator of neurogenesis, is elevated in medulloblastoma (MB) tumors. A cell‐intrinsic function for REST in MB tumorigenesis is known. However, a role for REST in the regulation of MB tumor microenvironment has not been investigated.
Shavali Shaik, Shinji Maegawa, Amanda R Haltom, Feng Wang, Xue Xiao, Tara Dobson, Ajay Sharma, Yanwen Yang, Jyothishmathi Swaminathan, Vikas Kundra, Xiao Nan Li, Keri Schadler, Arif Harmanci, Lin Xu, Vidya Gopalakrishnan   +14 more
openaire   +3 more sources

Ets1 facilitates EMT/invasion through Drp1-mediated mitochondrial fragmentation in ovarian cancer

iScience, 2023
Summary: Ovarian cancer has sustained as a major cause of cancer-related female mortality owing to its aggressive nature and a dearth of early detection markers.
Deepshikha Ghosh, Suman Pakhira, Damayanti Das Ghosh, Susanta Roychoudhury, Sib Sankar Roy   +4 more
doaj   +1 more source

Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: regulatory role for the protooncogene ETS1. [PDF]

Proceedings of the National Academy of Sciences, 1990
The expression of the protooncogenes ETS1 and ETS2 has been studied in purified human T cells activated either by cross-linking of the T-cell receptor-CD3 complex on their cell surface or by direct stimulation with phorbol esters and ionomycin. Our results show that resting T cells express high levels of ETS1 mRNA and protein, while expression of ETS2 ...
N K, Bhat, C B, Thompson, T, Lindsten, C H, June, S, Fujiwara, S, Koizumi, R J, Fisher, T S, Papas   +7 more
openaire   +2 more sources

Ets1 is an effector of protein kinase Cα in cancer cells [PDF]

Oncogene, 2004
PKCalpha and Ets1 are both associated with breast cancer progression. Our previous studies suggested that these proteins are likely to functionally interact with one another. Here, we show that attenuation of endogenous PKCalpha expression (siPalpha) by RNA interference leads to reduced Ets1 protein expression in a variety of cancer cells.
Martina, Vetter, Sibylle G, Blumenthal, Ralph K, Lindemann, Joachim, Manns, Sebastian, Wesselborg, Christoph, Thomssen, Jürgen, Dittmer   +6 more
openaire   +2 more sources

Transcription Factor ETS1 Promotes Glioma Cell Growth by Activating LncRNA XIST

Zhongliu Fangzhi Yanjiu
Objective To explore the biological function and downstream mechanism of ETS1 in glioma. Methods Bioinformatics and immunohistochemistry were used to analyze the differential expression characteristics of ETS1 in gliomas; qRT-PCR was employed to detect ...
LUO Ran, LUO Wenyi, LU Mingkai, ZHOU Meng, LIU Yanting, TIAN Chunlei   +5 more
doaj   +1 more source

Transcription factor ETS1 is critical for human uterine decidualization [PDF]

MHR: Basic science of reproductive medicine, 2006
The aim of this study was to examine whether the transcription factor ETS1 plays a critical role in the regulation of human decidualization. Decidual fibroblast cells were decidualized in vitro by treatment with medroxyprogesterone, estradiol (E(2)) and dibutyryl cyclic AMP or prostaglandin E(2) in the absence or presence of an ETS1 antisense ...
Cherie A, Kessler, Jennifer K, Schroeder, Anoop K, Brar, Stuart, Handwerger   +3 more
openaire   +2 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Ets1 Transcription Factor Mediates Gastrin-Releasing Peptide-Induced IL-8 Regulation in Neuroblastoma Cells

Neoplasia: An International Journal for Oncology Research, 2007
Angiogenesis plays a critical role in tumor progression in various cancers, including neuroblastoma. We have previously shown that gastrin-releasing peptide (GRP) stimulates neuroblastoma growth and that its cell surface receptors, gastrin-releasing ...
Jingbo Qiao, Jung-Hee Kang, Jeremy Cree, B. Mark Evers, Dai H. Chung   +4 more
doaj   +1 more source

LncRNA LINC00963 promotes osteogenic differentiation of hBMSCs and alleviates osteoporosis progression by targeting miRNA-760/ETS1 axis

Autoimmunity, 2021
Although long non-coding RNA LINC00963 has been reported to play a crucial regulatory role in osteoporosis (OP), its specific mechanism has not been well studied.
Lirong Ren, Limin Guo, Nannan Kou, Jia Lv, Zhihua Wang, Kaishun Yang   +5 more
doaj   +1 more source

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

Advanced Science, EarlyView.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li, Zhongya Zhai, Haiyi Yu, Renjie Qiu, Fengyu Li, Luxi Xiao, Boxi Huang, Huiying Liu, Jiayong He, Bowen Cai, Jiawen Chen, Jiang Yu, Guoxin Li, Tao Chen   +13 more
wiley   +1 more source