Results 31 to 40 of about 13,453 (162)

VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis

, 2017
Release of promoter-proximally paused RNA polymerase II (RNAPII) is a recently recognized transcriptional regulatory checkpoint. The biological roles of RNAPII pause release and the mechanisms by which extracellular signals control it are incompletely ...
Li, Kai, Sun, Ye, Zhang, Bing, Park, Peter, Pu, William, Fu, Yi, Smith, Lois, Wang, Shiyan, Sun, Kun, Stevens, Sean M., Day, Daniel S., Zhou, Pingzhu, Zhang, Jin, Chen, Jiahuan, Zhang, Fang, Lin, Ruei-zeng, Gu, Fei, Han, Zeguang, Liang, Xiaodong, Zhang, Yan, Melero-Martin, Juan   +20 more
core   +2 more sources

Transcription Factor ETS1 Promotes Glioma Cell Growth by Activating LncRNA XIST

Zhongliu Fangzhi Yanjiu
Objective To explore the biological function and downstream mechanism of ETS1 in glioma. Methods Bioinformatics and immunohistochemistry were used to analyze the differential expression characteristics of ETS1 in gliomas; qRT-PCR was employed to detect ...
LUO Ran, LUO Wenyi, LU Mingkai, ZHOU Meng, LIU Yanting, TIAN Chunlei   +5 more
doaj   +1 more source

Single‐Cell Dissection of Microglial Dysfunction in Diabetes‐Associated Neurodegenerative Vulnerability

Advanced Science, EarlyView.
Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang, Tsz Kwan Yau, Joyce Tse, Tsz Ho Li, Dongjie Hu, Yong Juan Zhao, Ting‐Fung Chan   +6 more
wiley   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Ets1 inhibits Min6 cell proliferation.

, 2014
(A). Min6 cells were infected with Ad-EGFP or Ad-Ets1 for 24 hrs and cell proliferation was determined by EdU labeling. (B). Min6 cells were infected with Ad-Ets1 and incubated with BrdU. Overexpressed Ets1 was detected with rabbit anti-Ets1 antibody and
Yan-Shan Dai (572516), Zhipeng Xu (198453), Zhiguang Zhou (131717), Fengli He (572513), Luo Hai (572514), Feng Liu (72874), Li Hu (326656), Jingjing Zhang (163589), Yan Luo (255674), Meifeng Huang (572515)   +9 more
core   +1 more source

ETS1 is associated with cisplatin resistance through IKKα/NF-κB pathway in cell line MDA-MB-231

Cancer Cell International, 2018
Background Platinum-based drugs are used extensively in neoadjuvant chemotherapy for triple-negative breast cancer (TNBC), but their use can be limited by resistance.
Yuzhu Zhang, Jingjing Wu, Meina Ye, Bing Wang, Jiayu Sheng, Bailing Shi, Hongfeng Chen   +6 more
doaj   +1 more source

Matrix Rigidity Mechanoprimes Microglia for Inflammation Through Cytoskeletal‐to‐Nuclear Signaling and 3D Spatio‐Epigenomic Remodeling

Advanced Science, EarlyView.
Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng, Jaegeon Joo, Yu Meng Li, Cheng Ji Li, Ali Taghizadeh, Seung Jae Shin, Buuvee Bayarkhangai, Tae‐Woo Ha, Sak Lee, Jaewoo Chung, Bo‐Eun Yoon, Hye Sung Kim, Inkyung Jung, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +15 more
wiley   +1 more source

Comparisons of mDCC maps between the (Ets1)₂–DNA and single Ets1–DNA models.

, 2014
The upper triangle shows mDCC values in the single Ets1–DNA model, with the color gradation from blue to red corresponding to mDCC values from −1.0 to 1.0. The lower triangle shows differences of the mDCC values in the single Ets1–DNA model from those in
Ikuo Fukuda (467002), Haruki Nakamura (9157), Kota Kasahara (281839)   +2 more
core   +1 more source

Ets1 Transcription Factor Mediates Gastrin-Releasing Peptide-Induced IL-8 Regulation in Neuroblastoma Cells

Neoplasia: An International Journal for Oncology Research, 2007
Angiogenesis plays a critical role in tumor progression in various cancers, including neuroblastoma. We have previously shown that gastrin-releasing peptide (GRP) stimulates neuroblastoma growth and that its cell surface receptors, gastrin-releasing ...
Jingbo Qiao, Jung-Hee Kang, Jeremy Cree, B. Mark Evers, Dai H. Chung   +4 more
doaj   +1 more source

Comparison of intermolecular hydrogen bonds in (Ets1)₂•2DNA and (Ets1)₂•DNA complexes.

, 2013
(A) Intermolecular hydrogen bonds between Ets1 and the neighboring DNA duplex within (Ets1)2•2DNA complex. (B) Intermolecular hydrogen bonds between Ets1 subunits in (Ets1)2•DNA complex.
Nigar D. Babayeva (329636), Tahir H. Tahirov (329638), Oxana I. Baranovskaya (329637)   +2 more
core   +1 more source