Results 31 to 40 of about 13,206 (170)

VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis

, 2017
Release of promoter-proximally paused RNA polymerase II (RNAPII) is a recently recognized transcriptional regulatory checkpoint. The biological roles of RNAPII pause release and the mechanisms by which extracellular signals control it are incompletely ...
Li, Kai, Sun, Ye, Zhang, Bing, Park, Peter, Pu, William, Fu, Yi, Smith, Lois, Wang, Shiyan, Sun, Kun, Stevens, Sean M., Day, Daniel S., Zhou, Pingzhu, Zhang, Jin, Chen, Jiahuan, Zhang, Fang, Lin, Ruei-zeng, Gu, Fei, Han, Zeguang, Liang, Xiaodong, Zhang, Yan, Melero-Martin, Juan   +20 more
core   +2 more sources

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

Advanced Science, EarlyView.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li, Haimin Chen, Gangqi Fang, Dongxiang Wei, Hongyun Wu, Chen Chen, Song Hong, Chengshu Wang   +7 more
wiley   +1 more source

Ets1-Mediated Acetylation of FoxO1 Is Critical for Gluconeogenesis Regulation during Feed-Fast Cycles

Cell Reports, 2019
Summary: The homeostatic balance of hepatic glucose uptake and production is exquisitely controlled by hormonal signals during feed-fast cycles.
Kai Li, Chen Qiu, Peng Sun, De-chen Liu, Ti-jun Wu, Kai Wang, Yun-cai Zhou, Xiao-ai Chang, Ye Yin, Fang Chen, Yun-xia Zhu, Xiao Han   +11 more
doaj   +1 more source

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

ETS1 is associated with cisplatin resistance through IKKα/NF-κB pathway in cell line MDA-MB-231

Cancer Cell International, 2018
Background Platinum-based drugs are used extensively in neoadjuvant chemotherapy for triple-negative breast cancer (TNBC), but their use can be limited by resistance.
Yuzhu Zhang, Jingjing Wu, Meina Ye, Bing Wang, Jiayu Sheng, Bailing Shi, Hongfeng Chen   +6 more
doaj   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Ets1 inhibits Min6 cell proliferation.

, 2014
(A). Min6 cells were infected with Ad-EGFP or Ad-Ets1 for 24 hrs and cell proliferation was determined by EdU labeling. (B). Min6 cells were infected with Ad-Ets1 and incubated with BrdU. Overexpressed Ets1 was detected with rabbit anti-Ets1 antibody and
Yan-Shan Dai (572516), Zhipeng Xu (198453), Zhiguang Zhou (131717), Fengli He (572513), Luo Hai (572514), Feng Liu (72874), Li Hu (326656), Jingjing Zhang (163589), Yan Luo (255674), Meifeng Huang (572515)   +9 more
core   +1 more source

Ets1 Transcription Factor Mediates Gastrin-Releasing Peptide-Induced IL-8 Regulation in Neuroblastoma Cells

Neoplasia: An International Journal for Oncology Research, 2007
Angiogenesis plays a critical role in tumor progression in various cancers, including neuroblastoma. We have previously shown that gastrin-releasing peptide (GRP) stimulates neuroblastoma growth and that its cell surface receptors, gastrin-releasing ...
Jingbo Qiao, Jung-Hee Kang, Jeremy Cree, B. Mark Evers, Dai H. Chung   +4 more
doaj   +1 more source

Molecular mechanisms of cooperative binding of transcription factors Runx1-CBFβ-Ets1 on the TCRα gene enhancer. [PDF]

PLoS ONE, 2017
Ets1 is an essential transcription factor (TF) for several important physiological processes, including cell proliferation and differentiation. Its recognition of the enhancer region of the TCRα gene is enhanced by the cooperative binding of the Runx1 ...
Kota Kasahara, Masaaki Shiina, Ikuo Fukuda, Kazuhiro Ogata, Haruki Nakamura   +4 more
doaj   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source