Results 51 to 60 of about 11,372 (171)

Regulation of hypoxia-inducible genes by ETS1 transcription factor [PDF]

Carcinogenesis, 2008
Hypoxia-inducible factor (HIF-1) regulates the expression of genes that facilitate tumor cell survival by making them more resistant to therapeutic intervention. Recent evidence suggests that the activation of other transcription factors, in cooperation with HIF-1 or acting alone, is involved in the upregulation of hypoxia-inducible genes.
Konstantin, Salnikow, Olga, Aprelikova, Sergey, Ivanov, Sean, Tackett, Monika, Kaczmarek, Aldona, Karaczyn, Herman, Yee, Kazimierz S, Kasprzak, John, Niederhuber   +8 more
openaire   +2 more sources

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

A Role for Autoinhibition in Preventing Dimerization of the Transcription Factor ETS1 [PDF]

Journal of Biological Chemistry, 2015
ETS1 is the archetype of the ETS transcription factor (TF) family. ETS TFs share a DNA-binding domain, the ETS domain. All ETS TFs recognize a core GGA(A/T) binding site, and thus ETS TFs are found to redundantly regulate the same genes. However, each ETS TF has unique targets as well.
Daniel, Samorodnitsky, Courtney, Szyjka, Gerald B, Koudelka   +2 more
openaire   +2 more sources

RUNX1‐Driven CPXM1 Transcription Promotes Malignant Phenotypes and EMT in Gastric Cancer Cells

Cancer Science, EarlyView.
RUNX1 transcriptionally activates CPXM1, promotes EMT, and enhances the proliferation, invasion, and metastasis of gastric cancer cells. ABSTRACT Gastric cancer (GC) remains a leading cause of cancer‐related mortality worldwide, with current treatment strategies largely limited to surgery, chemotherapy, and targeted therapy.
Ping Jia, Fengming Xu, Tao Zhou, Pingping Wang, Huiping Chen, Jing Zhang, Xiaochen Yuan, Haoxun Xu, Yu Ouyang   +8 more
wiley   +1 more source

Aberrant epidermal differentiation and disrupted ΔNp63/Notch regulatory axis in Ets1 transgenic mice

Biology Open, 2013
Summary The transcription factor Ets1 is expressed at low levels in epidermal keratinocytes under physiological conditions, but is over-expressed in cutaneous squamous cell carcinoma (SCC).
Shu Shien Chin, Rose-Anne Romano, Priyadharsini Nagarajan, Satrajit Sinha, Lee Ann Garrett-Sinha   +4 more
doaj   +1 more source

Ets family proteins regulate the EMT transcription factors Snail and ZEB in cancer cells

FEBS Open Bio, 2022
The epithelial–mesenchymal transition (EMT) is a crucial morphological event that occurs during epithelial tumor progression. Snail and ZEB1/2 (ZEB1 and ZEB2), known as EMT transcription factors, are key regulators of this transition.
Mai Koizumi Ichikawa, Kaori Endo, Yuka Itoh, Asami Hotta Osada, Yujiro Kimura, Koichiro Ueki, Kunio Yoshizawa, Keiji Miyazawa, Masao Saitoh   +8 more
doaj   +1 more source

Impact of G‐CSF on Donor TCR Clonal Diversity and T Cell Function During Donor HSC Mobilisation

Cell Proliferation, EarlyView.
In this study, we found that G‐CSF mobilisation caused a reduction in TCR clonal diversity and down‐regulation of T‐cell function in donors. This may be one of the reasons for the low incidence of GVHD mediated by G‐CSF after allo‐HSCT. Source: Created in BioRender. Li https://BioRender.com/otownki.
Xinye Li, Zhixi Chen, Jie Chen, Xingwei Zhang, Jiamian Zheng, Zirui Liu, Meixue Pan, Yue Li, Bo Yu, Shaohua Chen, Jing Lai, Xianfeng Zha, Liye Zhong, Yikai Zhang, Yangqiu Li   +14 more
wiley   +1 more source

EnABLing Cathepsin-Driven Melanoma Metastasis

Molecular & Cellular Oncology, 2018
Metastatic melanoma remains incurable for many due to its aggressive nature. Secreted cathepsins promote metastasis by cleaving matrix and activating pro-invasive proteases.
Rakshamani Tripathi, Rina Plattner
doaj   +1 more source

microRNA-9 suppresses the proliferation, invasion and metastasis of gastric cancer cells through targeting cyclin D1 and Ets1. [PDF]

PLoS ONE, 2013
Recent evidence shows that altered microRNA-9 (miR-9) expression is implicated in the progression of gastric cancer. However, the exact roles and underlying mechanisms of miR-9 in the proliferation, invasion and metastasis of gastric cancer still remain ...
Liduan Zheng, Teng Qi, Dehua Yang, Meng Qi, Dan Li, Xuan Xiang, Kai Huang, Qiangsong Tong   +7 more
doaj   +1 more source

Targeting Egfr‐Mediated Cell Proliferation and Lipid Metabolism Separation Effectively Accelerate Liver Regeneration

Cell Proliferation, EarlyView.
AREG coordinates cell proliferation and lipid metabolism reprogramming during liver regeneration and targeting lipid metabolism can promote liver regeneration. ABSTRACT Hepatocyte proliferation restores liver mass after partial hepatectomy (PHx), but the metabolic cost of this process remains unclear.
Yuelei Hu, Shifei Song, Ruilin Wang, Ni An, Jinmei Diao, Yuguo Chen, Juan Liu, Guoyue Lv   +7 more
wiley   +1 more source