Results 71 to 80 of about 11,372 (171)
MedComm, Volume 7, Issue 8, August 2026.Under homeostatic conditions, the lungs primarily harbor tissue‐resident alveolar macrophages (TR‐AMs). Intranasal immunization with A. baumannii IWC remodels the alveolar macrophage pool via two complementary mechanisms: recruitment and progressive differentiation of CD11B+CD13+ monocyte‐derived AMs, together with direct functional and epigenetic ...
Xiaomin Zhang +9 more
wiley +1 more source
Molecular Oncology, 2020 Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and young adults. RMS exists as two major disease subtypes, oncofusion‐negative RMS (FN‐RMS) and oncofusion‐positive RMS (FP‐RMS). FP‐RMS is characterized by recurrent PAX3/7‐FOXO1
Lays M. Sobral +8 more
doaj +1 more source
Journal of Innate Immunity, 2020 Children exposed to common aeroallergens may develop asthma that progresses into adulthood. Inflammation regulated by T helper 2 (Th2) cells, a specific subpopulation of CD4+ T lymphocytes, is involved in asthmatic injury.
Tianyue Wang +2 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, Volume 20, Issue 7, Page 1835-1856, July 2026.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Discovery of <i>ETS1</i> as a New Gene Predisposing to Dilated Cardiomyopathy. [PDF]
Diagnostics (Basel)Background/Objectives: Dilated cardiomyopathy (DCM), defined as dilation and contractile dysfunction of the left or both cardiac ventricles, remains the most common category of primary myocardial disease worldwide. It is the most prevalent cause of chronic heart failure and the most common indication for cardiac transplantation in young subjects ...
Ke ZP +7 more
europepmc +3 more sources
Ets1-Related Protein Is a Key Regulator of Vasculogenesis in Zebrafish
PLoS Biology, 2005 During embryonic development, multiple signaling pathways control specification, migration, and differentiation of the vascular endothelial cell precursors, angioblasts. No single gene responsible for the commitment of mesenchymal cells to the angioblast cell fate has been identified as yet.
Saulius Sumanas, Shuo Lin
openaire +4 more sources
PLoS Genetics, 2019 Head and Neck Squamous Cell Carcinoma (HNSCC) is a heterogeneous disease of significant mortality and with limited treatment options. Recent genomic analysis of HNSCC tumors has identified several distinct molecular classes, of which the mesenchymal ...
Christian Gluck +6 more
doaj +1 more source
M2 macrophages independently promote beige adipogenesis via blocking adipocyte Ets1
Nature CommunicationsAdipose tissue macrophages can promote beige adipose thermogenesis by altering local sympathetic activity. Here, we perform sympathectomy in mice and further eradicate subcutaneous adipose macrophages and discover that these macrophages have a direct ...
Suyang Wu +13 more
doaj +1 more source
The SAM domain of human TEL2 can abrogate transcriptional output from TEL1 (ETV-6) and ETS1/ETS2.
PLoS ONE, 2012 Regulation of gene expression downstream of the Receptor Tyrosine Kinase signaling pathway in Drosophila relies on a transcriptional effector network featuring two conserved Ets family proteins, Yan and Pointed, known as TEL1 (ETV6) and ETS1/ETS2 ...
Pavithra Vivekanand, Ilaria Rebay
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2019 Background Gliomas are common life-threatening cancers, mainly due to their aggressive nature and frequent invasiveness and long non-coding RNAs (lncRNAs) are emerging as promising molecular targets.
Haiyang Xu +7 more
doaj +1 more source