Results 71 to 80 of about 13,206 (170)

High‐Content CRISPR Screening: Methods and Applications

MedComm, Volume 7, Issue 9, September 2026.
High‐content CRISPR screening represents a paradigm shift in functional genomics, moving beyond traditional survival‐based readouts to enable multidimensional mapping of genotype–phenotype relationships. This review systematically outlines the methodological evolution of this approach, detailing advances in perturbation modalities, delivery systems ...
Yike Zhang, Yimeng Zhang, Xudong Tang, Xinyu Deng, Yitian Zhou, Yanfeng Wu, Jianhua Luo   +6 more
wiley   +1 more source

Ets1, a Key Regulator of TFH2 Cell Differentiation

, 2019
E26 transformation-specific-1 (Ets1) is a member of the Ets family of transcription factors and plays important functions in the development, proliferation, and survival of immune cells.
IM, SIN HYEOG
core  

Ebegboni...Caplen Additional replicates for Supplementary Figure S8A SK-N-MC-CRISPRa-ETS1-Vinculin and TNS3

This data presents additional confocal single channel and merged images for Supplementary Figure S8A -SK-N-MC-CRISPRa-ETS1-Vinculin and TNS3.
Natasha J. Caplen (14913966), Soumya Sundara Rajan (18126127), Vernon Ebegboni (18133593)   +2 more
core   +1 more source

Regulation of ETS1 Expression in Prostate Cancer Cells [PDF]

, 2014
ETS transcription factors are widely expressed during development and in adult tissues and regulate a variety of cellular processes including cell proliferation, migration and invasion.
Hope, Danika
core  

Overall structure of (Ets1)₂•2DNA.

, 2013
Two orthogonal views are shown. Ets1 molecules are drawn as cartoons and DNA molecules are drawn as sticks. The helices, strands and coils are shown in cyan, magenta and light brown colors in one Ets1 molecule and respectively in red, yellow and green in
Nigar D. Babayeva (329636), Tahir H. Tahirov (329638), Oxana I. Baranovskaya (329637)   +2 more
core   +1 more source

Rethinking Senescence Hallmarks in the Brain: Lessons From Peripheral Tissues and Challenges in Defining Neuronal Senescence

Aging Cell, Volume 25, Issue 9, September 2026.
Neuronal senescence‐like states arise from convergent intrinsic and disease‐associated stressors and are linked to persistent dysfunction, SASP‐like signaling, and altered glial interactions. Because no single marker is definitive in post‐mitotic neurons, multimarker and context‐dependent frameworks are required to define their role in ...
Miraj Ud Din Momand, Kristina Macova, Dominika Fricova   +2 more
wiley   +1 more source

Ets1, a Guardian of T Follicular Helper Cell Differentiation and SLE Development

, 2019
E26 transformation-specific-1 (Ets1) is a member of the Ets family of transcription factors and plays important functions in the development, proliferation, and survival of immune cells.
IM, SIN HYEOG
core  

Lupus Risk Variant Increases pSTAT1 Binding and Decreases ETS1 Expression [PDF]

, 2015
Genetic variants at chromosomal region 11q23.3, near the gene ETS1, have been associated with systemic lupus erythematosus (SLE), or lupus, in independent cohorts of Asian ancestry.
Sivils, Kathy L., Alarcón, Graciela S., Vyse, Timothy J, Choi, Jeongim, Tsao, Betty P, Kamen, Diane L., Weirauch, Matthew T., Weirauch, Matthew T, Glenn, Stuart B, Gilkeson, Gary S., Williams, Adrienne H, Brown, Elizabeth E., Vilá, Luis M, Ziegler, Julie T., Zoller, Erin E, Jacob, Chaim O, Sivils, Kathy L, Kimberly, Robert P, Kelly, Jennifer A, Marion, Miranda C., Joo, Young Bin, Alarcón-Riquelme, Marta E., Anaya, Juan Manuel, Langefeld, Carl D, Guthridge, Joel M, Gaffney, Patrick M, Reveille, John D., Bae, Sang-Cheol, Kaufman, Kenneth M, Williams, Adrienne H., Boackle, Susan A, Lu, Xiaoming, Freedman, Barry I, Scofield, R Hal, Scofield, R. Hal, Nath, Swapan K, Kamen, Diane L, Reveille, John D, Brown, Elizabeth E, Criswell, Lindsey A., Kelly, Jennifer A., Gilkeson, Gary S, Guthridge, Joel M., Criswell, Lindsey A, Nath, Swapan K., Ramsey-Goldman, Rosalind, Freedman, Barry I., Graham, Deborah Cunninghame, Wu, Zhiguo, Anaya, Juan-Manuel, Namjou, Bahram, Langefeld, Carl D., Vyse, Timothy J., Bin Joo, Young, Greis, Kenneth D., Greis, Kenneth D, Alarcón-Riquelme, Marta E, Shen, Nan, Kottyan, Leah C., Comeau, Mary E., Marion, Miranda C, Vilá, Luis M., Petri, Michelle, Jacob, Chaim O., James, Judith A., Ziegler, Julie T, Alarcón, Graciela S, Boackle, Susan A., Comeau, Mary E, Adler, Adam, Harley, John B., James, Judith A, Glenn, Stuart B., Tsao, Betty P., Zoller, Erin E., Kottyan, Leah C, Harley, John B, Bae, Sang Cheol, Stevens, Anne M., Gaffney, Patrick M., Stevens, Anne M, Kimberly, Robert P., Kaufman, Kenneth M.   +82 more
core   +1 more source

Impact of G‐CSF on Donor TCR Clonal Diversity and T Cell Function During Donor HSC Mobilisation

Cell Proliferation, Volume 59, Issue 9, September 2026.
In this study, we found that G‐CSF mobilisation caused a reduction in TCR clonal diversity and down‐regulation of T‐cell function in donors. This may be one of the reasons for the low incidence of GVHD mediated by G‐CSF after allo‐HSCT. Source: Created in BioRender. Li https://BioRender.com/otownki.
Xinye Li, Zhixi Chen, Jie Chen, Xingwei Zhang, Jiamian Zheng, Zirui Liu, Meixue Pan, Yue Li, Bo Yu, Shaohua Chen, Jing Lai, Xianfeng Zha, Liye Zhong, Yikai Zhang, Yangqiu Li   +14 more
wiley   +1 more source

Targeting Egfr‐Mediated Cell Proliferation and Lipid Metabolism Separation Effectively Accelerate Liver Regeneration

Cell Proliferation, Volume 59, Issue 9, September 2026.
AREG coordinates cell proliferation and lipid metabolism reprogramming during liver regeneration and targeting lipid metabolism can promote liver regeneration. ABSTRACT Hepatocyte proliferation restores liver mass after partial hepatectomy (PHx), but the metabolic cost of this process remains unclear.
Yuelei Hu, Shifei Song, Ruilin Wang, Ni An, Jinmei Diao, Yuguo Chen, Juan Liu, Guoyue Lv   +7 more
wiley   +1 more source