Results 81 to 90 of about 13,206 (170)

Interstitial 11q Deletions and Terminal 11q Duplications Cause a Bleeding Tendency due to Platelet Dysfunction That Is Similar to 11q Deletions Causing Jacobsen Syndrome

European Journal of Haematology, Volume 117, Issue 3, Page 662-672, September 2026.
ABSTRACT Introduction Jacobsen syndrome, resulting from a terminal deletion of chromosome 11 (11q), may lead to an increased bleeding tendency due to low platelet counts or platelet dysfunction. Currently, information on bleeding tendency and platelet function in patients with nonterminal 11q‐aberrations such as larger deletions, interstitial 11q ...
Elise J. Huisman, Virgil A. S. H. Dalm, Marieke Joosten, Frans J. Smiers, Leendert Porcelijn, Arjan Hoogendijk, Hans Janssen, Nicole N. van der Wel, Idske C. L. Kremer Hovinga, Masja de Haas, Marjon H. Cnossen   +10 more
wiley   +1 more source

KDM3A/Ets1 epigenetic axis contributes to PAX3/FOXO1‐driven and independent disease‐promoting gene expression in fusion‐positive Rhabdomyosarcoma

Molecular Oncology, 2020
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and young adults. RMS exists as two major disease subtypes, oncofusion‐negative RMS (FN‐RMS) and oncofusion‐positive RMS (FP‐RMS). FP‐RMS is characterized by recurrent PAX3/7‐FOXO1
Lays M. Sobral, Hannah M. Hicks, Janet K. Parrish, Tyler S. McCann, Joseph Hsieh, Andrew Goodspeed, James C. Costello, Joshua C. Black, Paul Jedlicka   +8 more
doaj   +1 more source

Single‐Cell Immune Profiling Suggests Non‐Classical Monocyte Is Associated Immunodepression in Tuberculosis Treatment Non‐Responders

Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
ABSTRACT Sputum culture conversion (SCC) at 2 months is an early indicator of tuberculosis (TB) treatment response, yet the associated immune alterations remain incompletely defined. We performed single‐cell RNA sequencing on peripheral blood mononuclear cells from eight TB patients, stratified by 2‐month SCC status.
Yiqun Xiong, Yahong Qu, Ying Wang, Dongliang Zhang, Hao Shen, Weixin Wang, Junshun Gao, ZhenBo Wang, Zhihong Shen, Yang Che   +9 more
wiley   +1 more source

Ets1 and ERα expression in human breast cell lines.

, 2013
A. Breast cell lines were analyzed by Western blot for ERα and Ets1 with tubulin as a loading control. B. ER-positive BT-474, MCF7, T47D and ZR-75-1 cells were analyzed by qRT-PCR for Ets1 transcript levels. Data represent mean ± standard deviation. Ets1
Dawn L. Duval (431965), Anne Handschy (431961), Charles Halsey (431963), Christopher Korch (357537), Liza E. O’Donoghue (431962), Laura Chubb (431964), Brian T. Kalet (431959), Sara R. Anglin (431960)   +7 more
core   +1 more source

ETS1 and HLHS: Implications for the Role of the Endocardium

, 2022
We have identified the ETS1 gene as the cause of congenital heart defects, including an unprecedented high frequency of HLHS, in the chromosomal disorder Jacobsen syndrome. Studies in Ciona intestinalis demonstrated a critical role for ETS1 in heart cell
Grossfeld, Paul, Paul Grossfeld
core   +1 more source

Identification and analysis of global ETS1 target genes.

, 2019
Sankey plot showing target genes of ETS1 based on the integration of RNA-Seq and ChIP-Seq data-sets. The tails of the plot display selected ETS1-dependent pathways revealed by gene-set enrichment analysis.
Maria Tsompana (3037167), Norma Nowak (6954422), Lee Ann Garrett-Sinha (267960), Michael J. Buck (222992), Alexandra Glathar (6954419), Satrajit Sinha (28564), Christian Gluck (3453233)   +6 more
core   +1 more source

Silencing of ETS1 reverses adriamycin resistance in MCF-7/ADR cells via downregulation of MDR1 [PDF]

, 2014
Background\ud Clinical resistance to chemotherapeutic agents is one of the major hindrances in the treatment of human cancers. Erythroblastosis virus E26 oncogene homolog 1 (ETS1) is involved in the drug resistance of various cancer cells, and is ...
Dong Xiao, Wei, Jinrong, Xiao, Dong, Xiao, D, Zhou, Yong, Zhou, Y, Jinrong Wei, Jiang, Guo-Qin, Jiang, GQ, Guo-Qin Jiang, Wei, J, Yong Zhou   +11 more
core   +1 more source

Implication of p16 Promoter Methylation, the BRAFV600E Mutation, and ETS1 Expression Determination on Papillary Thyroid Carcinoma Prognosis and High-Risk Patients’ Selection

Biomedicines
Background/Objectives: Papillary thyroid carcinoma (PTC) is the most common malignancy of the endocrine system, characterized by various molecular alterations.
Stefana Stojanović Novković, Sonja Šelemetjev, Milena Krajnović, Ana Božović, Bojana Kožik, Uršula Prosenc Zmrzljak, Tijana Išić Denčić   +6 more
doaj   +1 more source

Drug resistant breast cancer cells overexpress ETS1 gene

, 2010
Purpose. - Multidrug resistance (MDR) is resistance to wide range of structurally unrelated anticancer agents. MDR is a serious limitation to the effective chemotherapy.
Kars, Meltem Demirel, Gündüz, Ufuk, Iseri, Ozlem Darcansoy   +2 more
core   +1 more source

Ets1 inhibits glucose-induced insulin secretion and induces expression of TXNIP in mouse islets.

, 2014
(A). Adenoviral mediated overexpression of Ets1 inhibited glucose-stimulated insulin secretion in cultured mouse islet cells. Islets overexpressing EGFP were used as controls. Insulin concentration in the culture media was measured by mouse insulin ELISA
Yan-Shan Dai (572516), Zhipeng Xu (198453), Zhiguang Zhou (131717), Fengli He (572513), Luo Hai (572514), Feng Liu (72874), Li Hu (326656), Jingjing Zhang (163589), Yan Luo (255674), Meifeng Huang (572515)   +9 more
core   +1 more source