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The Biology of the Ets1 Proto-Oncogene
Molecular Cancer, 2003 The Ets1 proto-oncoprotein is a member of the Ets family of transcription factors that share a unique DNA binding domain, the Ets domain. The DNA binding activity of Ets1 is controlled by kinases and transcription factors.
Dittmer Jürgen
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SNP rs4937333 in the miRNA-5003-Binding Site of the ETS1 3′-UTR Decreases ETS1 Expression [PDF]
Frontiers in Genetics, 2019 Mutations in and reduced expression of the ETS1 gene may be associated with systemic lupus erythematosus (SLE). Here, we report a replication study to investigate associations of eight ETS1 single-nucleotide polymorphisms in the 3′-untranslated region (3′
Ruixian Zhang +4 more
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ETS1 and HLHS: Implications for the Role of the Endocardium
Journal of Cardiovascular Development and Disease, 2022 We have identified the ETS1 gene as the cause of congenital heart defects, including an unprecedented high frequency of HLHS, in the chromosomal disorder Jacobsen syndrome. Studies in Ciona intestinalis demonstrated a critical role for ETS1 in heart cell
Paul Grossfeld
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ETS1 regulates the expression of ATXN2 [PDF]
Human Molecular Genetics, 2012 Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant disorder caused by the expansion of a CAG tract in the ATXN2 gene. The SCA2 phenotype is characterized by cerebellar ataxia, neuropathy and slow saccades. SCA2 foreshortens life span and is currently without symptomatic or disease-modifying treatments.
Daniel R, Scoles +5 more
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Scientific Reports, 2022 Primary Sjögren’s syndrome (pSS) patients exhibit enhanced degradation of the salivary epithelium initially through MMP9 overexpression. We assessed the expression of MMP9 and an associated transcription factor, ETS1, in primary salivary gland epithelial
Braxton Noll +3 more
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Ets1 gene (Ets Proto-Oncogene1) expression changes in patients with celiac disease under a gluten-free diet [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریز, 2023 Background. One of the effective genes in the pathogenesis of the celiac disease is the Ets1 gene, which encodes the transcription factor Ets1 and is highly conserved during evolution.
Maedeh Nafari +3 more
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Acta Biochimica et Biophysica Sinica, 2022 Hyperglycemia-induced endothelial inflammation participates in the pathogenesis of cardiovascular complications in diabetics. Previous studies showed that protein tyrosine phosphatase 1B (PTP1B) and ETS proto-oncogene 1 (ets1) are involved in ...
Jiang Lili +4 more
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MicroRNA 17-92 cluster mediates ETS1 and ETS2-dependent RAS-oncogenic transformation. [PDF]
PLoS ONE, 2014 The ETS-family transcription factors Ets1 and Ets2 are evolutionarily conserved effectors of the RAS/ERK signaling pathway, but their function in Ras cellular transformation and biology remains unclear.
Mohamed Kabbout +7 more
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Structural basis of Ets1 cooperative binding to widely separated sites on promoter DNA. [PDF]
PLoS ONE, 2012 Ets1 is a member of the Ets family of transcription factors. Ets1 is expressed in autoinhibited form and its DNA binding depends on partner proteins bound to adjacent sequences or the relative positioning of a second Ets-binding site (EBS).
Nigar D Babayeva +2 more
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Frontiers in Physiology, 2021 ETS proto-oncogene 1 (ETS1) has been implicated in osteoporosis (OP), but the exact molecular mechanisms are complex. This work focuses on the impact of ETS1 on the osteogenic differentiation and the molecules involved.
Renyao Li, Ying Dong, Feipeng Li
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