MicroRNA 17-92 cluster mediates ETS1 and ETS2-dependent RAS-oncogenic transformation. [PDF]
PLoS ONE, 2014 The ETS-family transcription factors Ets1 and Ets2 are evolutionarily conserved effectors of the RAS/ERK signaling pathway, but their function in Ras cellular transformation and biology remains unclear.
Mohamed Kabbout +7 more
doaj +2 more sources
Transcription factor Ets1 regulates expression of thioredoxin-interacting protein and inhibits insulin secretion in pancreatic β-cells. [PDF]
PLoS ONE, 2014 Long-term activation of extracellular-regulated kinase (ERK1/2) pathway has been shown to cause glucotoxicity and inhibit insulin gene expression in β-cells.
Yan Luo +9 more
doaj +2 more sources
ETS1 Suppresses Tumorigenesis of Human Breast Cancer via Trans-Activation of Canonical Tumor Suppressor Genes [PDF]
Frontiers in Oncology, 2020 ETS1 has shown dichotomous roles as an oncogene and a tumor suppressor gene in diverse cancers, but its functionality in breast cancer tumorigenesis still remains unclear.
Gi-Cheon Kim +13 more
doaj +2 more sources
Molecular mechanisms of cooperative binding of transcription factors Runx1-CBFβ-Ets1 on the TCRα gene enhancer. [PDF]
PLoS ONE, 2017 Ets1 is an essential transcription factor (TF) for several important physiological processes, including cell proliferation and differentiation. Its recognition of the enhancer region of the TCRα gene is enhanced by the cooperative binding of the Runx1 ...
Kota Kasahara +4 more
doaj +2 more sources
Ets1 facilitates EMT/invasion through Drp1-mediated mitochondrial fragmentation in ovarian cancer
iScience, 2023 Summary: Ovarian cancer has sustained as a major cause of cancer-related female mortality owing to its aggressive nature and a dearth of early detection markers.
Deepshikha Ghosh +4 more
doaj +2 more sources
A targeted CRISPR screen identifies ETS1 as a regulator of HIV-1 latency. [PDF]
PLoS PathogensHuman Immunodeficiency virus (HIV) infection is regulated by a wide array of host cell factors that combine to influence viral transcription and latency.
Manickam Ashokkumar +6 more
doaj +3 more sources
ETS1 Expression in Diabetic Foot Ulcers: Implications for Fibroblast Phenotype and Wound Healing Through the PP2A/YAP Pathway [PDF]
Journal of Inflammation ResearchWenjuan Yi,1 Qionglin Bao,2 Dingkun Xu,3 Chenyu Long,1 Ruixin Fang,1 Wenlin Cheng,4 Jiquan Song,1 Huiting Feng1 1Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China; 2Wound Repair Center, Chronic Wound and ...
Yi W +7 more
doaj +1 more source
Scientific Reports, 2022 Primary Sjögren’s syndrome (pSS) patients exhibit enhanced degradation of the salivary epithelium initially through MMP9 overexpression. We assessed the expression of MMP9 and an associated transcription factor, ETS1, in primary salivary gland epithelial
Braxton Noll +3 more
doaj +1 more source
Acta Biochimica et Biophysica Sinica, 2022 Hyperglycemia-induced endothelial inflammation participates in the pathogenesis of cardiovascular complications in diabetics. Previous studies showed that protein tyrosine phosphatase 1B (PTP1B) and ETS proto-oncogene 1 (ets1) are involved in ...
Jiang Lili +4 more
doaj +1 more source
Ets1 induces dysplastic changes when expressed in terminally-differentiating squamous epidermal cells. [PDF]
PLoS ONE, 2009 BACKGROUND: Ets1 is an oncogene that functions as a transcription factor and regulates the activity of many genes potentially important for tumor initiation and progression.
Priyadharsini Nagarajan +3 more
doaj +1 more source