The Biology of the Ets1 Proto-Oncogene [PDF]
Molecular Cancer, 2003 The Ets1 proto-oncoprotein is a member of the Ets family of transcription factors that share a unique DNA binding domain, the Ets domain. The DNA binding activity of Ets1 is controlled by kinases and transcription factors.
Dittmer Jürgen
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Structural basis of Ets1 cooperative binding to widely separated sites on promoter DNA. [PDF]
PLoS ONE, 2012 Ets1 is a member of the Ets family of transcription factors. Ets1 is expressed in autoinhibited form and its DNA binding depends on partner proteins bound to adjacent sequences or the relative positioning of a second Ets-binding site (EBS).
Nigar D Babayeva +2 more
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Ets1 induces dysplastic changes when expressed in terminally-differentiating squamous epidermal cells. [PDF]
PLoS ONE, 2009 BACKGROUND: Ets1 is an oncogene that functions as a transcription factor and regulates the activity of many genes potentially important for tumor initiation and progression.
Priyadharsini Nagarajan +3 more
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ETS1 Suppresses Tumorigenesis of Human Breast Cancer via Trans-Activation of Canonical Tumor Suppressor Genes [PDF]
Frontiers in Oncology, 2020 ETS1 has shown dichotomous roles as an oncogene and a tumor suppressor gene in diverse cancers, but its functionality in breast cancer tumorigenesis still remains unclear.
Gi-Cheon Kim +13 more
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MicroRNA 17-92 cluster mediates ETS1 and ETS2-dependent RAS-oncogenic transformation. [PDF]
PLoS ONE, 2014 The ETS-family transcription factors Ets1 and Ets2 are evolutionarily conserved effectors of the RAS/ERK signaling pathway, but their function in Ras cellular transformation and biology remains unclear.
Mohamed Kabbout +7 more
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A targeted CRISPR screen identifies ETS1 as a regulator of HIV-1 latency. [PDF]
PLoS PathogensHuman Immunodeficiency virus (HIV) infection is regulated by a wide array of host cell factors that combine to influence viral transcription and latency.
Manickam Ashokkumar +6 more
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M2 macrophages independently promote beige adipogenesis via blocking adipocyte Ets1
Nature CommunicationsAdipose tissue macrophages can promote beige adipose thermogenesis by altering local sympathetic activity. Here, we perform sympathectomy in mice and further eradicate subcutaneous adipose macrophages and discover that these macrophages have a direct ...
Suyang Wu +13 more
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ETS1 Expression in Diabetic Foot Ulcers: Implications for Fibroblast Phenotype and Wound Healing Through the PP2A/YAP Pathway [PDF]
Journal of Inflammation ResearchWenjuan Yi,1 Qionglin Bao,2 Dingkun Xu,3 Chenyu Long,1 Ruixin Fang,1 Wenlin Cheng,4 Jiquan Song,1 Huiting Feng1 1Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China; 2Wound Repair Center, Chronic Wound and ...
Yi W +7 more
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Acta Biochimica et Biophysica Sinica, 2022 Hyperglycemia-induced endothelial inflammation participates in the pathogenesis of cardiovascular complications in diabetics. Previous studies showed that protein tyrosine phosphatase 1B (PTP1B) and ETS proto-oncogene 1 (ets1) are involved in ...
Jiang Lili +4 more
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Ets1 gene (Ets Proto-Oncogene1) expression changes in patients with celiac disease under a gluten-free diet [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریز, 2023 Background. One of the effective genes in the pathogenesis of the celiac disease is the Ets1 gene, which encodes the transcription factor Ets1 and is highly conserved during evolution.
Maedeh Nafari +3 more
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