Results 21 to 30 of about 11,372 (171)

Caspase-1 Is a Direct Target Gene of ETS1 and Plays a Role in ETS1-Induced Apoptosis [PDF]

Cancer Research, 2005
Abstract ETS1, the founding member of Ets transcriptional factor family, plays an important role in cell proliferation, differentiation, lymphoid cell development, transformation, angiogenesis, and apoptosis. Previous work has shown that ETS1 represses tumorigenicity of colon carcinoma cells in vivo, and that the p42-ETS1 protein ...
Huiping, Pei, Chunyang, Li, Yair, Adereth, Tien, Hsu, Dennis K, Watson, Runzhao, Li   +5 more
openaire   +2 more sources

Transcription factor Ets1 cooperates with estrogen receptor α to stimulate estradiol-dependent growth in breast cancer cells and tumors. [PDF]

PLoS ONE, 2013
The purpose of this study was to explore the role of transcription factor Ets1 in estrogen receptor α (ERα)-positive breast cancer progression. We expressed human Ets1 or empty vector in four human ERα-positive breast cancer cell lines and observed ...
Brian T Kalet, Sara R Anglin, Anne Handschy, Liza E O'Donoghue, Charles Halsey, Laura Chubb, Christopher Korch, Dawn L Duval   +7 more
doaj   +1 more source

Structural basis of Ets1 activation by Runx1 [PDF]

Leukemia, 2014
Runx1 is required for definitive hematopoiesis and is well known for its frequent chromosomal translocations and point mutations in leukemia. Runx1 regulates a variety of genes via Ets1 activation on an Ets1•Runx1 composite DNA sequence. The structural basis of such regulation remains unresolved.
Shrivastava, Tripti, Mino, Koshiki, Babayeva, Nigar D., I.Baranovskaya, Oxana, Rizzino, Angie, Tahirov, Tahir H.   +5 more
openaire   +2 more sources

DNA specificity determinants associate with distinct transcription factor functions. [PDF]

PLoS Genetics, 2009
To elucidate how genomic sequences build transcriptional control networks, we need to understand the connection between DNA sequence and transcription factor binding and function.
Peter C Hollenhorst, Katherine J Chandler, Rachel L Poulsen, W Evan Johnson, Nancy A Speck, Barbara J Graves   +5 more
doaj   +1 more source

ETS1, ELK1, and ETV4 Transcription Factors Regulate Angiopoietin-1 Signaling and the Angiogenic Response in Endothelial Cells

Frontiers in Physiology, 2021
BackgroundAngiopoietin-1 (Ang-1) is the main ligand of Tie-2 receptors. It promotes endothelial cell (EC) survival, migration, and differentiation. Little is known about the transcription factors (TFs) in ECs that are downstream from Tie-2 receptors ...
Sharon Harel, Sharon Harel, Sharon Harel, Veronica Sanchez, Veronica Sanchez, Veronica Sanchez, Alaa Moamer, Alaa Moamer, Alaa Moamer, Javier E. Sanchez-Galan, Mohammad N. Abid Hussein, Dominique Mayaki, Dominique Mayaki, Dominique Mayaki, Mathieu Blanchette, Sabah N. A. Hussain, Sabah N. A. Hussain, Sabah N. A. Hussain   +17 more
doaj   +1 more source

The Role of microRNA-15A in the Development of Prostate Cancer – Effects on Cell Proliferation and Pro-Inflammatory Signalling

Acta Medica Bulgarica, 2018
Worldwide prostate cancer is the second leading cause of cancer death among men after lung cancer. MicroRNAs are non-coding, endogenous RNAs and they play a role in tumorigenesis, RNA silencing and post-transcriptional regulation of gene expression.
Apostolova A., Sezer L., Hayrabedyan S., Todorova Kr.   +3 more
doaj   +1 more source

ETS1 Suppresses Tumorigenesis of Human Breast Cancer via Trans-Activation of Canonical Tumor Suppressor Genes

Frontiers in Oncology, 2020
ETS1 has shown dichotomous roles as an oncogene and a tumor suppressor gene in diverse cancers, but its functionality in breast cancer tumorigenesis still remains unclear.
Gi-Cheon Kim, Gi-Cheon Kim, Choong-Gu Lee, Ravi Verma, Dipayan Rudra, Taemook Kim, Keunsoo Kang, Jong Hee Nam, Young Kim, Sin-Hyeog Im, Sin-Hyeog Im, Ho-Keun Kwon, Ho-Keun Kwon, Ho-Keun Kwon   +13 more
doaj   +1 more source

Uncovering a Key Role of ETS1 on Vascular Abnormality in Glioblastoma [PDF]

Pathology and Oncology Research, 2021
Glioblastoma (GBM) is the most aggressive type of brain tumor. Microvascular proliferation and abnormal vasculature are the hallmarks of the GBM, aggravating disease progression and increasing patient morbidity. Here, we uncovered a key role of ETS1 on vascular abnormality in glioblastoma.
Tang, Jiefu, Li, Yaling, Liu, Boxuan, Liang, Wei, Hu, Sanbao, Shi, Meilian, Zeng, Jie, Li, Mingzhen, Huang, Minjiang   +8 more
openaire   +2 more sources

ETS1 Induces Human Trophoblast Differentiation

Endocrinology, 2015
A possible role for the transcription factor v-ets avian erythroblastosis virus E26 oncogene homolog 1 (ETS1) in human trophoblast cell differentiation was examined using a highly enriched fraction of human mononuclear cytotrophoblast cells (CTBs) that differentiate spontaneously in vitro to a multinucleated syncytiotrophoblast cell (STB) phenotype ...
Cherie A, Kessler, Jerzy W, Stanek, Keith F, Stringer, Stuart, Handwerger   +3 more
openaire   +3 more sources

Aberrant expression of ETS1 and ETS2 proteins in cancer [PDF]

Cancer Reports and Reviews, 2018
The ETS transcription factors regulate expression of genes involved in normal cell development, proliferation, differentiation, angiogenesis, and apoptosis, consisting of 28 family members in humans. Dysregulation of these transcription factors facilitates cell proliferation in cancers, and several members participate in invasion and metastasis by ...
Elizabeth A, Fry, Kazushi, Inoue
openaire   +2 more sources