Results 21 to 30 of about 13,453 (162)

Ets1 gene (Ets Proto-Oncogene1) expression changes in patients with celiac disease under a gluten-free diet [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز, 2023
Background. One of the effective genes in the pathogenesis of the celiac disease is the Ets1 gene, which encodes the transcription factor Ets1 and is highly conserved during evolution.
Maedeh Nafari, Flora Forouzesh, Mohammad Javad Ehsani-Ardakani, Mohammad Rostami-Nejad   +3 more
doaj   +1 more source

Structural basis of Ets1 cooperative binding to widely separated sites on promoter DNA. [PDF]

PLoS ONE, 2012
Ets1 is a member of the Ets family of transcription factors. Ets1 is expressed in autoinhibited form and its DNA binding depends on partner proteins bound to adjacent sequences or the relative positioning of a second Ets-binding site (EBS).
Nigar D Babayeva, Oxana I Baranovskaya, Tahir H Tahirov   +2 more
doaj   +1 more source

ETS Proto-Oncogene 1 Suppresses MicroRNA-128 Transcription to Promote Osteogenic Differentiation Through the HOXA13/β-Catenin Axis

Frontiers in Physiology, 2021
ETS proto-oncogene 1 (ETS1) has been implicated in osteoporosis (OP), but the exact molecular mechanisms are complex. This work focuses on the impact of ETS1 on the osteogenic differentiation and the molecules involved.
Renyao Li, Ying Dong, Feipeng Li
doaj   +1 more source

Ets1 suppresses atopic dermatitis by suppressing pathogenic T cell responses [PDF]

, 2019
Atopic dermatitis (AD) is a complex inflammatory skin disease mediated by immune cells of both adaptive and innate types. Among them, CD4(+) Th cells are one of major players of AD pathogenesis.
Chang-Duk Jun, Young Kim, Lee, CG, Zee Yong Park, Hyeji Kang, IM, SIN HYEOG, Kim, Y, Kim, T, Park, S, Park, ZY, Keunsoo Kang, Kwon, HK, Young Ho Won, Taemook Kim, Sin-Hyeog Im, Nam, JH, Jun, CD, Choong-Gu Lee, Rudra, D, Kang, H, Won, YH, Ho-Keun Kwon, Jong Hee Nam, Dipayan Rudra, Sunhee Park, Kang, K, Kang, Keunsoo, Lee, Choong-Gu, Kim, Young, Park, Zee Yong, Rudra, Dipayan, Kang, Hyeji, Park, Sunhee, Kwon, Ho-Keun, Kim, Taemook, Jun, Chang-Duk, Im, Sin-Hyeog, 권호근, Nam, Jong Hee, Won, Young Ho   +39 more
core   +3 more sources

Transcription factor Ets1 cooperates with estrogen receptor α to stimulate estradiol-dependent growth in breast cancer cells and tumors. [PDF]

PLoS ONE, 2013
The purpose of this study was to explore the role of transcription factor Ets1 in estrogen receptor α (ERα)-positive breast cancer progression. We expressed human Ets1 or empty vector in four human ERα-positive breast cancer cell lines and observed ...
Brian T Kalet, Sara R Anglin, Anne Handschy, Liza E O'Donoghue, Charles Halsey, Laura Chubb, Christopher Korch, Dawn L Duval   +7 more
doaj   +1 more source

Metabolic‐Redox Remodeling of Inflammatory Synovium by Mannose‐Modified Selenium Nanoparticles for Osteoarthritis Therapy [PDF]

Advanced science
Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Zou Y, Xu C, Li B, Chan L, Xu Y, Su H, Peng R, Luo F, Peng Y, Li Z, Wong V, Zheng X, Ma X, Zha Z, Chen T, Zhang H.   +15 more
europepmc   +2 more sources

DNA specificity determinants associate with distinct transcription factor functions. [PDF]

PLoS Genetics, 2009
To elucidate how genomic sequences build transcriptional control networks, we need to understand the connection between DNA sequence and transcription factor binding and function.
Peter C Hollenhorst, Katherine J Chandler, Rachel L Poulsen, W Evan Johnson, Nancy A Speck, Barbara J Graves   +5 more
doaj   +1 more source

The Role of microRNA-15A in the Development of Prostate Cancer – Effects on Cell Proliferation and Pro-Inflammatory Signalling

Acta Medica Bulgarica, 2018
Worldwide prostate cancer is the second leading cause of cancer death among men after lung cancer. MicroRNAs are non-coding, endogenous RNAs and they play a role in tumorigenesis, RNA silencing and post-transcriptional regulation of gene expression.
Apostolova A., Sezer L., Hayrabedyan S., Todorova Kr.   +3 more
doaj   +1 more source

ETS1, ELK1, and ETV4 Transcription Factors Regulate Angiopoietin-1 Signaling and the Angiogenic Response in Endothelial Cells

Frontiers in Physiology, 2021
BackgroundAngiopoietin-1 (Ang-1) is the main ligand of Tie-2 receptors. It promotes endothelial cell (EC) survival, migration, and differentiation. Little is known about the transcription factors (TFs) in ECs that are downstream from Tie-2 receptors ...
Sharon Harel, Sharon Harel, Sharon Harel, Veronica Sanchez, Veronica Sanchez, Veronica Sanchez, Alaa Moamer, Alaa Moamer, Alaa Moamer, Javier E. Sanchez-Galan, Mohammad N. Abid Hussein, Dominique Mayaki, Dominique Mayaki, Dominique Mayaki, Mathieu Blanchette, Sabah N. A. Hussain, Sabah N. A. Hussain, Sabah N. A. Hussain   +17 more
doaj   +1 more source

SNP rs4937333 in the miRNA-5003-Binding Site of the ETS1 3′-UTR Decreases ETS1 Expression

Frontiers in Genetics, 2019
Mutations in and reduced expression of the ETS1 gene may be associated with systemic lupus erythematosus (SLE). Here, we report a replication study to investigate associations of eight ETS1 single-nucleotide polymorphisms in the 3′-untranslated region (3′
Ruixian Zhang, Ruixian Zhang, Bangpin Pan, Yi Li, Xiaolan Li   +4 more
doaj   +1 more source