Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, frequently coincide with insertions in the gene encoding the peripheral cannabinoid receptor Cnr2 [PDF]
, 1999 The common virus integration site (VIS) Evi11 was recently identified within the gene encoding the hematopoietic G-protein-coupled peripheral cannabinoid receptor Cnr2 (also ...
Copeland, N.G. +6 more
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Oxidized LDL Induces Pro‐Inflammatory Transcriptomic and Epigenomic Responses in Human CD4+ T Cells
The FASEB Journal, Volume 40, Issue 4, 28 February 2026.Oxidized low‐density lipoprotein (ox‐LDL) induces transcription of a pro‐inflammatory cytokine network in CD4+ T cells. The transcriptional effects of ox‐LDL are coordinated by the NRF1 and SP1 transcription factors. We show overlap of coronary artery disease (CAD)‐associated loci and ox‐LDL‐regulated accessible chromatin regions, including the ...
Toby A. Brown +3 more
wiley +1 more source
Indian Journal of Pathology and Microbiology, 2016 Background: Prostate carcinoma is the second leading cause of cancer-related deaths in males worldwide. The burden is expected to grow 1.7 million new cases and 499,000 new deaths by 2030.
Rahul Mannan +5 more
doaj +1 more source
Serielle Genexpressionsanalyse der Neointimabildung nach Ballonangioplastie im humanen Organkulturmodell mittels DNA Array-Technologie: Neue Erkenntnisse zur Wirkung von Rapamycin [PDF]
, 2005 Hintergrund und Fragestellung Eines der schwerwiegenden Probleme der interventionellen Kardiologie stellte bislang die koronare Restenose im Stent dar.
Nührenberg, Thomas
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ChemMedChem, Volume 21, Issue 4, 25 February 2026.Polypharmacology is expected to produce higher therapeutic efficacy and lower cytotoxic and side effects. Compound 15 exhibited strong inhibition of the human carbonic anhydrase isoforms IX and XII and selectivity toward the adverse isoforms I and II.
Michela Puxeddu +21 more
wiley +1 more source
Molecular Mechanisms and Therapeutic Potential of DJ‐1 in Skeletal Muscle Homeostasis and Disease
Comprehensive Physiology, Volume 16, Issue 1, February 2026.DJ‐1 protein functions as a redox‐sensing guardian in skeletal muscle by coordinating antioxidant defense, mitochondrial homeostasis, metabolic adaptation, and anti‐atrophy signaling. Enhancing its function holds promise as a potential therapeutic strategy for muscle atrophy, ALS, and metabolic myopathies.
Yue Zhang +5 more
wiley +1 more source
AML associated oncofusion proteins PML-RARA, AML1-ETO and CBFB-MYH11 target RUNX/ETS-factor binding sites to modulate H3ac levels and drive leukemogenesis [PDF]
, 2016 Chromosomal translocations are one of the hallmarks of acute myeloid leukemia (AML), often leading to gene fusions and expression of an oncofusion protein.
Laakso, Marko +4 more
core +1 more source
Ventilator‐Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets
MedComm, Volume 7, Issue 2, February 2026.Mechanical ventilation (MV) is expected to undergo significant transformative advancements by 2050, with the emergence of personalized ventilation systems that promise to revolutionize respiratory care. However, the risk of ventilator‐induced lung injury (VILI) remains a significant concern at this stage and VILI still exists at that time.
He Ren +4 more
wiley +1 more source
Upregulation of Ets1 expression by NFATc2 and NFKB1/RELA promotes breast cancer cell invasiveness
Oncogenesis, 2018 Breast cancer is highly aggressive and is the leading cause of cancer-related mortality in women in developed countries. The ETS proto-oncogene 1 (Ets1) has versatile roles during the cellular processes of cancer development. It is often highly expressed
Gicheon Kim +9 more
semanticscholar +1 more source
Deletions of the derivative chromosome 9 occur at the time of the Philadelphia translocation and provide a powerful and independent prognostic indicator in chronic myeloid leukemia [PDF]
, 2001 Chronic myeloid leukemia (CML) is characterized by formation of the BCR-ABL fusion gene, usually as a consequence of the Philadelphia (Ph) translocation between chromosomes 9 and 22.
Bench, AJ +11 more
core +1 more source