Results 91 to 100 of about 30,453 (235)

DNA methylation as a predictor of pituitary neuroendocrine tumour behaviour: A systematic review

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Abstract Pituitary neuroendocrine tumours (PitNETs) range from slow‐growing to highly aggressive tumours; however, traditional prognostic markers often fail to predict clinical outcomes reliably. DNA methylation has recently emerged as a promising biomarker for assessing tumour behaviour. This systematic review evaluates its predictive value in PitNETs.
Romy van der Groef, Eskeatnaf Mulugeta, Sebastian Neggers, Julie Refardt   +3 more
wiley   +1 more source

Myb proteins inhibit fibroblast transformation by v-Rel [PDF]

, 2006
Genes that cause cancer have been divided into two general classes – oncogenes that act in a dominant fashion to transform normal cells into a malignant state, and tumor suppressor genes that act in a dominant fashion to prevent such transformation.
Lipsick Joseph S, Ganter Brigitte, Fu Shu-ling   +2 more
core   +1 more source

Mitophagy and Ubiquitination Coordinate Context‐Specific Mitochondrial Quality Control and EMT/MET Plasticity to Drive Cancer Cell Invasion

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Metastatic invasion emerges when tumor‐intrinsic programs and microenvironmental forces converge on mitochondrial quality control. A context‐stratified framework links mtROS, mtDNA integrity, mechanics and nutrient/oxygen cues to fission–fusion remodeling, mtUPR and mitophagy.
Bin‐Hsu Mao, Bo‐Kai Su, Ying‐Jan Wang, Ting‐Yuan Tu   +3 more
wiley   +1 more source

LncRNA USP2-AS1 facilitates the osteogenic differentiation of bone marrow mesenchymal stem cells by targeting KDM3A/ETS1/USP2 to activate the Wnt/β-catenin signaling pathway

RNA Biology
Human bone marrow mesenchymal stem cells (HBMSCs) can promote new bone formation. Previous studies have proven the ability of long non-coding RNAs (lncRNAs) to modulate the osteogenic differentiation of mesenchymal stem cells.
Wanxin Luo, Na Zhang, Ziping Wang, Hao Chen, Jie Sun, Chen Yao, Yafeng Zhang   +6 more
doaj   +1 more source

ETS1, nucleolar and non-nucleolar TERT expression in nevus to melanoma progression. [PDF]

, 2017
TERT (telomerase reverse transcriptase) is the catalytic component of telomerase. TERT shows little expression in normal somatic cells but is commonly re-expressed in cancers, facilitating immortalization.
Bahrami, Bennett, Bennett, Bennett, Bennett, Bennett, Bennett, Bosserhoff, Cardoso, Cech, Cech, Chung, Collins, Dumaz, Ekfors, Flørenes, Fountain, Garraway, Hara, Heenan, Herbig, Hockemeyer, Huang, Huang, Kumar, Kumar, Kumar, Marais, Morgan, Murakami, Parwaresch, Peeper, Prabhakar, Preto, Reed, Rizos, Robson, Serrano, Shay, Shay, Soares, Terns, Tucker, Van Horn, Weinberg, Wright   +45 more
core   +3 more sources

Type 2 Diabetes From the Perspective of Telomere Biology

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 2, March 2026.
This graphical abstract illustrates the bidirectional relationship between the telomere/telomerase system and T2DM: telomere attrition contributes to pancreatic β‐cell dysfunction and insulin resistance through mechanisms such as oxidative stress and apoptosis, while T2DM‐related hyperglycemia and chronic inflammation further exacerbate telomere damage.
Hongye Cao, Haixia Feng, Zhen Shen, Yanqin Huang   +3 more
wiley   +1 more source

Molecular medicine of microRNAs: structure, function and implications for diabetes [PDF]

, 2008
MicroRNAs (miRNAs) are a family of endogenous small noncoding RNA molecules, of 19–28 nucleotides in length. In humans, up to 3% of all genes are estimated to encode these evolutionarily conserved sequences.
Duncan, Erica Hennessy, Lorraine O'Driscoll, Offield, Schleicher, Zhou   +5 more
core   +1 more source

Artificial Intelligence and Prostate–Breast Cancer Biology: Recent Advances in Treatments and Perspectives — A Comprehensive Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims The therapeutic limitations of conventional cancer treatment currently deployed are driving the development and creation of new nano‐drugs. Prostate cancer (PCa) is a prevalent clinical problem in older men with a significant global incidence, with 1.5 million cases reported in 2022.
Russell B. O. Ouma, Silas M. Ngari, Joshua K. Kibet   +2 more
wiley   +1 more source

WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1

Molecular Cancer, 2019
Background N6-methyladenosine (m6A) methylation, a well-known modification with new epigenetic functions, has been reported to participate in the tumorigenesis of hepatocellular carcinoma (HCC), providing novel insights into the molecular pathogenesis of
Yunhao Chen, Chuanhui Peng, Junru Chen, Diyu Chen, Beng Yang, Bin He, Wendi Hu, Yanpeng Zhang, Hua Liu, Longfei Dai, Haiyang Xie, Lin Zhou, Jian Wu, Shusen Zheng   +13 more
doaj   +1 more source

Recent Progress in Treating Airway Mucus Hypersecretion by Targeting the Epidermal Growth Factor Receptor Signaling Pathway

Pediatric Discovery, Volume 4, Issue 1, March 2026.
ABSTRACT Asthma, chronic pulmonary obstructive disease (COPD), cystic fibrosis, and acute respiratory infections are severe respiratory conditions that significantly contribute to global morbidity and mortality. Airway mucus hypersecretion is an important common pathophysiological and clinical manifestation of these diseases and is closely associated ...
Yuanyuan Zhang, Fuping Yang, Chunyu Yan, Yu Deng, Enmei Liu   +4 more
wiley   +1 more source