Results 91 to 100 of about 116,033,210 (184)

Constitutive activation of the ETS-1-miR-222 circuitry in metastatic melanoma

, 2011
MicroRNAs-221 and -222 are highly upregulated in several solid tumors, including melanomas. We demonstrate that the proto-oncogene ETS-1, involved in the pathogenesis of cancers of different origin, is a transcriptional regulator of miR-222 by direct ...
and Colombo MP, Gianfranco Mattia, and Felicetti F, Lisabianca Bottero, and Tomasello L, Marina Petrini, M. Cristina Errico, Alessandra Carè, Antonio Di Virgilio, Mattia G, Alessandra Boe, Mario P. Colombo, and Errico MC, and di Virgilio A, and Carè A., Luisa Tomasello, and Bottero L, and Segnalini P, Paolo Romania, Federica Felicetti, and Petrini M, Patrizia Segnalini, Romania P, and Boe A   +23 more
core   +1 more source

Salsalate improves the anti-tumor efficacy of lenvatinib in MASH-driven hepatocellular carcinoma

JHEP Reports
Background & Aims: Metabolic dysfunction-associated steatohepatitis (MASH) is a growing cause of hepatocellular carcinoma (HCC) worldwide. The complex microenvironment of these tumors, characterized by metabolic dysfunction, hypoxia, steatosis, and ...
Evangelia E. Tsakiridis, Elham Ahmadi, Jaya Gautam, Yi Ran Hannah She, Russta Fayyazi, James S.V. Lally, Simon Wang, Fiorella Di Pastena, Celina M. Valvano, Daniel Del Rosso, Olga-Demetra Biziotis, Brandon Meyers, Paola Muti, Theodoros Tsakiridis, Gregory R. Steinberg   +14 more
doaj   +1 more source

Circular RNA_0000326 promotes bladder cancer progression via microRNA-338-3p/ETS Proto-Oncogene 1/phosphoinositide-3 kinase/Akt pathway. [PDF]

Bioengineered, 2021
Chen Y, Wang D, Shu T, Sun K, Zhao J, Wang M, Huang Y, Wang P, Zheng H, Cai Z, Yang Z.   +10 more
europepmc   +1 more source

Mechanism of lncRNA SNHG16 on kidney clear cell carcinoma cells by targeting miR-506-3p/ETS1/RAS/ERK molecular axis

Heliyon
Objective: This study aimed to investigate the mechanism of long noncoding ribonucleic acid (lncRNA) SNHG16 on kidney clear cell carcinoma (KIRC) cells by targeting miR-506-3p/ETS proto-oncogene 1, transcription factor (ETS1)/RAS/Extracellular regulated ...
Tao Cheng, Ming-Li Gu, Wei-Qiang Xu, Da-Wen Ye, Ze-Yu Zha, Wen-Ge Fang, Li-Kai Mao, Jing Ning, Xing-Bang Hu, Yong-Hui Ding   +9 more
doaj   +1 more source

ID2-ETS2 axis regulates the transcriptional acquisition of pro-tumoral microglia phenotype in glioma

Cell Death and Disease
Glioblastoma is a highly aggressive brain tumour that creates an immunosuppressive microenvironment. Microglia, the brain’s resident immune cells, play a crucial role in this environment.
Guillermo Vázquez-Cabrera, Martin Škandík, Noémie Roncier, Farah Real Oualit, Mireia Cruz De Los Santos, Austeja Baleviciute, Mathilde Cheray, Bertrand Joseph   +7 more
doaj   +1 more source

Single-cell identifies and validates human circulating Treg subtype/state Treg fci in non-small cell lung cancer

Signal Transduction and Targeted Therapy
Regulatory T cells (Treg) play immunosuppressive roles in lung cancer and are key biomarkers in cancer immunology. Using scRNA-seq and stereo-seq, we aimed to identify a novel circulating Treg subtype in non-small cell lung cancer (NSCLC). We developed a
Xuanqi Liu, Yifei Liu, Wanxin Duan, Jianming Weng, Hao Dai, Fangming Liu, Lingyan Wang, Mengjia Qian, Bijun Zhu, Shuyao Wu, Youqiong Ye, Muhan Yuan, Shaojun Hong, Mingjie Wang, Yunfeng Cheng, Tianxiang Chen, Duojiao Wu, Yuanlin Song, Xiangdong Wang   +18 more
doaj   +1 more source

Proto-oncogene Ets-1 is pathologically expressed in low-grade astrocytomas and glioblastomas in a tissue and location specific pattern and correlates with patient survival.

Journal of Clinical Oncology, 2014
e13016 Background: Ets-1 regulates migration & angiogenesis and is active in malignomas. Methods: We investigated Ets-1 in 60 glioblastomas WHO IV° & 40 astrocytomas WHO II° and evaluated its progn...
Kuhn, Susanne Antje, Pfeifenbring, Sabine, Schirrmeister, Anne, Kratzsch, Tobias, Traeger, Uwe, Hanlsch, Uwe Karsten, Haberl, Hennes   +6 more
openaire   +2 more sources

Genomic Dispersal of the ets Gene Family during Metazoan Evolution

, 1992
Evolutionary homologs of the ets proto-oncogene have been discovered in the genomes of widely divergent eucaryote species from Drosophila to sea urchin to vertebrates.
Burdett, L. A., Lautenberger, J. A., O\u27Brien, Stephen J., Qi, S., Gunnell, M. A., Papas, T. S., Watson, D. K.   +6 more
core  

MIAT promotes tumor-infiltrating CD8+ T-cell exhaustion and malignant progression of renal cell carcinoma via activating JAK3/STAT3 pathway

Journal for ImmunoTherapy of Cancer
Background The hyporesponsiveness of tumor-infiltrating exhausted CD8+ T cells to tumor cells contributes to immune escape of renal cell carcinoma (RCC), representing a major challenge in current immunotherapy. However, the underlying molecular mechanism
Bin Wang, Jian-Feng Wang, Jun-Hang Luo, Ming-xiao Zhang, Lan-yu Jing, Hao-tian Tan, Zi-ran Dai, Da-zhi Long, Han-chao Liu, An-ze Yu, Zi-yin Chen, Zhen-hua Chen   +11 more
doaj   +1 more source

Long Non-Coding RNA CASC19 Sponges microRNA-532 and Promotes Oncogenicity of Clear Cell Renal Cell Carcinoma by Increasing ETS1 Expression

Cancer Management and Research, 2020
Yu Luo, Feng Liu, Chunhui Yan, Wei Qu, Liang Zhu, Zheng Guo, Fan Zhou, Wei Zhang Department of Urology, The 161st Hospital of the People’s Liberation Army, Wuhan, Hubei 430010, People’s Republic of ChinaCorrespondence: Feng LiuDepartment of ...
Luo Y, Liu F, Yan C, Qu W, Zhu L, Guo Z, Zhou F, Zhang W   +7 more
doaj