Results 91 to 100 of about 13,787 (194)

ID2-ETS2 axis regulates the transcriptional acquisition of pro-tumoral microglia phenotype in glioma

Cell Death and Disease
Glioblastoma is a highly aggressive brain tumour that creates an immunosuppressive microenvironment. Microglia, the brain’s resident immune cells, play a crucial role in this environment.
Guillermo Vázquez-Cabrera, Martin Škandík, Noémie Roncier, Farah Real Oualit, Mireia Cruz De Los Santos, Austeja Baleviciute, Mathilde Cheray, Bertrand Joseph   +7 more
doaj   +1 more source

Ets-1: a new player in the pathogenesis of systemic lupus erythematosus? [PDF]

, 2011
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) (Ets-1) is a member of the Ets family of transcription factors that share a unique Ets DNA binding domain.
H-F Pan, J-H Tao, X-P Li, D-Q Ye, R-X Leng   +4 more
core   +1 more source

Single-cell identifies and validates human circulating Treg subtype/state Treg fci in non-small cell lung cancer

Signal Transduction and Targeted Therapy
Regulatory T cells (Treg) play immunosuppressive roles in lung cancer and are key biomarkers in cancer immunology. Using scRNA-seq and stereo-seq, we aimed to identify a novel circulating Treg subtype in non-small cell lung cancer (NSCLC). We developed a
Xuanqi Liu, Yifei Liu, Wanxin Duan, Jianming Weng, Hao Dai, Fangming Liu, Lingyan Wang, Mengjia Qian, Bijun Zhu, Shuyao Wu, Youqiong Ye, Muhan Yuan, Shaojun Hong, Mingjie Wang, Yunfeng Cheng, Tianxiang Chen, Duojiao Wu, Yuanlin Song, Xiangdong Wang   +18 more
doaj   +1 more source

MIAT promotes tumor-infiltrating CD8+ T-cell exhaustion and malignant progression of renal cell carcinoma via activating JAK3/STAT3 pathway

Journal for ImmunoTherapy of Cancer
Background The hyporesponsiveness of tumor-infiltrating exhausted CD8+ T cells to tumor cells contributes to immune escape of renal cell carcinoma (RCC), representing a major challenge in current immunotherapy. However, the underlying molecular mechanism
Bin Wang, Jian-Feng Wang, Jun-Hang Luo, Ming-xiao Zhang, Lan-yu Jing, Hao-tian Tan, Zi-ran Dai, Da-zhi Long, Han-chao Liu, An-ze Yu, Zi-yin Chen, Zhen-hua Chen   +11 more
doaj   +1 more source

Genomic Dispersal of the ets Gene Family during Metazoan Evolution [PDF]

, 1992
Evolutionary homologs of the ets proto-oncogene have been discovered in the genomes of widely divergent eucaryote species from Drosophila to sea urchin to vertebrates.
Burdett, L. A., Lautenberger, J. A., O\u27Brien, Stephen J., Qi, S., Gunnell, M. A., Papas, T. S., Watson, D. K.   +6 more
core  

Long Non-Coding RNA CASC19 Sponges microRNA-532 and Promotes Oncogenicity of Clear Cell Renal Cell Carcinoma by Increasing ETS1 Expression

Cancer Management and Research, 2020
Yu Luo, Feng Liu, Chunhui Yan, Wei Qu, Liang Zhu, Zheng Guo, Fan Zhou, Wei Zhang Department of Urology, The 161st Hospital of the People’s Liberation Army, Wuhan, Hubei 430010, People’s Republic of ChinaCorrespondence: Feng LiuDepartment of ...
Luo Y, Liu F, Yan C, Qu W, Zhu L, Guo Z, Zhou F, Zhang W   +7 more
doaj  

Proto-oncogene Ets-1 is pathologically expressed in low-grade astrocytomas and glioblastomas in a tissue and location specific pattern and correlates with patient survival.

Journal of Clinical Oncology, 2014
e13016 Background: Ets-1 regulates migration & angiogenesis and is active in malignomas. Methods: We investigated Ets-1 in 60 glioblastomas WHO IV° & 40 astrocytomas WHO II° and evaluated its progn...
Kuhn, Susanne Antje, Pfeifenbring, Sabine, Schirrmeister, Anne, Kratzsch, Tobias, Traeger, Uwe, Hanlsch, Uwe Karsten, Haberl, Hennes   +6 more
openaire   +2 more sources

A prognostic risk prediction model for gastric cancer based on the EFNA4 and ETS1 regulatory axis in tumor cells

Scientific Reports
Gastric cancer (GC) is a major cause of cancer-related deaths worldwide, and is characterised by intricate molecular mechanisms. However, analysis of its molecular and clinical characteristics is complicated by its histological and etiological ...
Yixuan Chen, Ning Wang, Junkun Wang, Shupei Li, Wenchen Zhang, Wenjiang Deng, Jingjing Ye, Zhoujuan Yao, Hui Zhang, Fengsong Wang, Wenbin Wang   +10 more
doaj   +1 more source

Investigating the molecular basic of AMKL and MDS. [PDF]

, 2008
Malignant haematopoiesis is usually associated with various genetic lesions such as chromosomal translocations or mutations in individual genes. This thesis investigates the genetic basis of two such syndromes, acute megakaryoblastic leukaemia (AMKL) and
Salek-Ardakani, S.
core  

The c-ets-1 proto-oncogene is rearranged in some cases of acute lymphoblastic leukaemia [PDF]

British Journal of Cancer, 1987
M H, Goyns, I M, Hann, J, Stewart, A, Gegonne, G D, Birnie   +4 more
openaire   +2 more sources